CA1077932A - Xanthine compounds and method of treating bronchospastic and allergic diseases - Google Patents
Xanthine compounds and method of treating bronchospastic and allergic diseasesInfo
- Publication number
- CA1077932A CA1077932A CA274,520A CA274520A CA1077932A CA 1077932 A CA1077932 A CA 1077932A CA 274520 A CA274520 A CA 274520A CA 1077932 A CA1077932 A CA 1077932A
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- alkyl
- dimethyl
- butyl
- xanthine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/672,437 US4089959A (en) | 1976-03-31 | 1976-03-31 | Long-acting xanthine bronchodilators and antiallergy agents |
US05/672,388 US4120947A (en) | 1976-03-31 | 1976-03-31 | Xanthine compounds and method of treating bronchospastic and allergic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1077932A true CA1077932A (en) | 1980-05-20 |
Family
ID=27100746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA274,520A Expired CA1077932A (en) | 1976-03-31 | 1977-03-22 | Xanthine compounds and method of treating bronchospastic and allergic diseases |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS52122396A (zh) |
CA (1) | CA1077932A (zh) |
DE (1) | DE2713389A1 (zh) |
FR (1) | FR2346353A1 (zh) |
GB (1) | GB1561005A (zh) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE416810C (sv) * | 1977-10-14 | 1982-07-19 | Draco Ab | Forfarande for framstellning av xantinderivat med antiallergisk aktivitet |
SE7810946L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | Metod att behandla kronisk obstruktiv luftvegssjukdom |
SE7810947L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | 3-alkylxanthines |
SE8002910L (sv) * | 1980-04-18 | 1981-10-19 | Draco Ab | 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar |
CH643260A5 (fr) * | 1980-05-02 | 1984-05-30 | Nestle Sa | 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament. |
FR2611716A1 (fr) * | 1987-03-06 | 1988-09-09 | Uriach Cia Sa J | Derives de diisobutylxanthine substituee en position 7 utiles comme bronchodilatateurs, procede pour leur preparation et composition pharmaceutique les contenant |
GB8826595D0 (en) * | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
US5321029A (en) * | 1988-11-14 | 1994-06-14 | Beecham-Wuelfing Gmbh & Co.K.G. | Xanthines |
IT1229195B (it) * | 1989-03-10 | 1991-07-25 | Poli Ind Chimica Spa | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
JP2001523213A (ja) | 1994-12-13 | 2001-11-20 | ユーロ−セルティーク,エス.エイ. | 三置換チオキサンチン類 |
US6066641A (en) * | 1994-12-13 | 2000-05-23 | Euro-Celtique S.A. | Aryl thioxanthines |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
US5864037A (en) | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2729643A (en) * | 1956-01-03 | J-disubstmjied and i |
-
1977
- 1977-03-22 CA CA274,520A patent/CA1077932A/en not_active Expired
- 1977-03-23 DE DE19772713389 patent/DE2713389A1/de active Granted
- 1977-03-28 GB GB12923/77A patent/GB1561005A/en not_active Expired
- 1977-03-31 JP JP3555977A patent/JPS52122396A/ja active Granted
- 1977-03-31 FR FR7709680A patent/FR2346353A1/fr active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2346353A1 (fr) | 1977-10-28 |
FR2346353B1 (zh) | 1980-03-07 |
GB1561005A (en) | 1980-02-13 |
DE2713389C2 (zh) | 1992-03-19 |
JPS52122396A (en) | 1977-10-14 |
DE2713389A1 (de) | 1977-10-13 |
JPS5720313B2 (zh) | 1982-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4089959A (en) | Long-acting xanthine bronchodilators and antiallergy agents | |
US4120947A (en) | Xanthine compounds and method of treating bronchospastic and allergic diseases | |
CA1077932A (en) | Xanthine compounds and method of treating bronchospastic and allergic diseases | |
US5734051A (en) | 8-substituted xanthine derivatives and method of use thereof | |
US4644001A (en) | 3-Alkylxanthines, composition and methods for the treatment of chronic obstructive-airway disease and cardiac disease | |
AU683270B2 (en) | Novel chemical compounds having PDE-IV inhibition activity | |
EP0011609B1 (en) | Xanthine derivatives and pharmaceutical preparations containing these derivatives for use in the treatment of chronic obstructive airway disease and cardiac disease | |
PL166152B1 (en) | Method of obtaining novel xantine derivatives | |
CA2209125A1 (en) | Compounds for and method of inhibiting phosphodiesterase iv | |
EP0001735A1 (en) | Xanthine derivatives having antiallergic activity and pharmacological preparations containing them | |
JPH0780882B2 (ja) | 6‐チオキサンチン誘導体 | |
CA1271473A (en) | 8-arylxanthines | |
US6440979B1 (en) | Aryl isoguanines | |
CA1156229A (en) | 3.8-dialkylxanthines, processes for their preparation, composition and methods for the treatment of chronic obstructive airway disease and cardiovascular diseases | |
US6319928B1 (en) | Purine derivatives having phosphodiesterase IV inhibition activity | |
EP0531349A1 (en) | 1-7 substituted xanthine derivatives having antiasthmatic activity, their salts physiologically acceptable, pharmaceutical composition containing them and process for their preparation | |
US6294541B1 (en) | Purine derivatives having phosphodiesterase IV inhibition activity | |
US6248746B1 (en) | 3-(arylalkyl) xanthines | |
DE69531555T2 (de) | Dreifachsubstituierte thioxanthine | |
CA1142928A (en) | 3-alkylxanthines, intermediates, processes for their preparation, composition and methods for the treatment of chronic obstructive airway disease and cardiac disease | |
JPH05262770A (ja) | 化学的製法 | |
EP0407651A2 (en) | Use of 1,3-diisobutyl-8-methylxanthine as a bronchodilator and antiallergy agent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |