CA1038757A - Inactivation de microorganismes par suspension dans de l'ethyleneimine - Google Patents
Inactivation de microorganismes par suspension dans de l'ethyleneimineInfo
- Publication number
- CA1038757A CA1038757A CA193,307A CA193307A CA1038757A CA 1038757 A CA1038757 A CA 1038757A CA 193307 A CA193307 A CA 193307A CA 1038757 A CA1038757 A CA 1038757A
- Authority
- CA
- Canada
- Prior art keywords
- ethyleneimine
- suspension
- concentration
- virus
- destroyed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 239000000725 suspension Substances 0.000 claims abstract description 30
- 230000005847 immunogenicity Effects 0.000 claims abstract description 19
- 244000005700 microbiome Species 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims description 42
- 241000700605 Viruses Species 0.000 claims description 32
- 241000894006 Bacteria Species 0.000 claims description 21
- 230000008569 process Effects 0.000 claims description 19
- 241000606860 Pasteurella Species 0.000 claims description 6
- 239000004133 Sodium thiosulphate Substances 0.000 claims description 4
- 238000009877 rendering Methods 0.000 claims description 4
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 4
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 4
- 230000006735 deficit Effects 0.000 claims 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 230000002458 infectious effect Effects 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000726306 Irus Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 230000000937 inactivator Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- OTIXUSNHAKOJBX-UHFFFAOYSA-N 1-(aziridin-1-yl)ethanone Chemical compound CC(=O)N1CC1 OTIXUSNHAKOJBX-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010051497 Rhinotracheitis Diseases 0.000 description 1
- 241000223109 Trypanosoma cruzi Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229960001212 bacterial vaccine Drugs 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- -1 ethylene- Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32161—Methods of inactivation or attenuation
- C12N2770/32163—Methods of inactivation or attenuation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2309329A DE2309329C2 (de) | 1973-02-24 | 1973-02-24 | Verwendung von Äthyleniminlösungen als Inaktivierungsmittel bei der Herstellung von Impfstoffen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1038757A true CA1038757A (fr) | 1978-09-19 |
Family
ID=5873014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA193,307A Expired CA1038757A (fr) | 1973-02-24 | 1974-02-22 | Inactivation de microorganismes par suspension dans de l'ethyleneimine |
Country Status (11)
| Country | Link |
|---|---|
| BR (1) | BR7401197D0 (fr) |
| CA (1) | CA1038757A (fr) |
| CS (1) | CS191909B2 (fr) |
| DE (1) | DE2309329C2 (fr) |
| DK (1) | DK132766C (fr) |
| ES (1) | ES423617A1 (fr) |
| FR (1) | FR2230346A1 (fr) |
| HU (1) | HU171544B (fr) |
| IN (1) | IN139338B (fr) |
| PL (1) | PL88703B1 (fr) |
| RO (1) | RO64304A (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU78955A1 (de) * | 1978-01-27 | 1979-09-06 | Chimicasa Gmbh | Verfahren zur inaktivierung von viren |
-
1973
- 1973-02-24 DE DE2309329A patent/DE2309329C2/de not_active Expired
-
1974
- 1974-02-19 BR BR1197/74A patent/BR7401197D0/pt unknown
- 1974-02-19 RO RO7400077745A patent/RO64304A/fr unknown
- 1974-02-21 CS CS741291A patent/CS191909B2/cs unknown
- 1974-02-22 HU HU74BA00003034A patent/HU171544B/hu unknown
- 1974-02-22 FR FR7406237A patent/FR2230346A1/fr active Granted
- 1974-02-22 DK DK97974*#A patent/DK132766C/da not_active IP Right Cessation
- 1974-02-22 CA CA193,307A patent/CA1038757A/fr not_active Expired
- 1974-02-23 PL PL1974169031A patent/PL88703B1/pl unknown
- 1974-02-25 ES ES423617A patent/ES423617A1/es not_active Expired
- 1974-02-26 IN IN401/CAL/74A patent/IN139338B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2230346B1 (fr) | 1977-11-04 |
| PL88703B1 (fr) | 1976-09-30 |
| DK132766C (da) | 1976-07-05 |
| IN139338B (fr) | 1976-06-05 |
| HU171544B (hu) | 1978-02-28 |
| DE2309329C2 (de) | 1983-05-11 |
| CS191909B2 (en) | 1979-07-31 |
| ES423617A1 (es) | 1976-11-01 |
| BR7401197D0 (pt) | 1974-11-05 |
| DE2309329A1 (de) | 1974-08-29 |
| RO64304A (fr) | 1978-08-15 |
| DK132766B (da) | 1976-02-02 |
| FR2230346A1 (en) | 1974-12-20 |
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