CA1015758A - 6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamides - Google Patents
6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamidesInfo
- Publication number
- CA1015758A CA1015758A CA197,107A CA197107A CA1015758A CA 1015758 A CA1015758 A CA 1015758A CA 197107 A CA197107 A CA 197107A CA 1015758 A CA1015758 A CA 1015758A
- Authority
- CA
- Canada
- Prior art keywords
- quinolizine
- carboxamides
- tetrazol
- benzo
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1627973A GB1433151A (en) | 1973-04-05 | 1973-04-05 | Benzo-ij-quinolizines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1015758A true CA1015758A (en) | 1977-08-16 |
Family
ID=10074459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA197,107A Expired CA1015758A (en) | 1973-04-05 | 1974-04-05 | 6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamides |
Country Status (14)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051247A (en) * | 1975-04-14 | 1977-09-27 | Riker Laboratories, Inc. | Method of using 7-hydroxy-benzo[ij]quinolizine-2-carboxylic acid derivatives |
| AT377986B (de) * | 1978-08-31 | 1985-05-28 | Otsuka Pharma Co Ltd | Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen |
| JPS5540616A (en) * | 1978-09-14 | 1980-03-22 | Otsuka Pharmaceut Co Ltd | Preparation of benzo-hetero-compound |
| AT377987B (de) * | 1979-04-11 | 1985-05-28 | Otsuka Pharma Co Ltd | Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen |
| US4400386A (en) * | 1981-11-06 | 1983-08-23 | Riker Laboratories, Inc. | Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine |
| US4472407A (en) * | 1983-03-17 | 1984-09-18 | Riker Laboratories, Inc. | Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu |
| US4650804A (en) * | 1984-03-30 | 1987-03-17 | Fujisawa Pharmaceutical Co., Ltd. | Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents |
| CA1266484A (en) * | 1984-12-14 | 1990-03-06 | Ronald Edward Mac Leay | Tert-octylhydrazine, its salts and derivatives |
| DE3519926A1 (de) * | 1985-06-04 | 1986-12-04 | Bayer Ag | Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel |
| WO1997030999A1 (en) * | 1996-02-21 | 1997-08-28 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| US5792774A (en) * | 1996-02-21 | 1998-08-11 | Chiroscience Limited | Quinolones and their therapeutic use |
| AU710876B2 (en) * | 1996-02-21 | 1999-09-30 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| RU2556984C2 (ru) * | 2004-06-24 | 2015-07-20 | Вертекс Фармасьютикалз Инкорпорейтед | Модуляторы транспортеров атф-связывающей кассеты |
| BR122018075478B8 (pt) | 2004-06-24 | 2023-10-31 | Vertex Pharma | moduladores de transportadores de cassete de ligação de atp |
| EP2502912A3 (en) * | 2004-06-24 | 2013-11-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| HUE049976T2 (hu) | 2005-12-28 | 2020-11-30 | Vertex Pharma | N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói |
| SG10201504084QA (en) | 2009-03-20 | 2015-06-29 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CN109966264A (zh) | 2012-02-27 | 2019-07-05 | 沃泰克斯药物股份有限公司 | 药物组合物及其施用 |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3728350A (en) * | 1967-07-17 | 1973-04-17 | Lilly Co Eli | 1-(2-carboxyphenyl)-5,7-dimethoxy-3,4-dihydrocarbostyril intermediates for acronycis |
| US3793328A (en) * | 1969-11-03 | 1974-02-19 | Upjohn Co | 8benzoyl 1,2,3,4 tetrahydroquinoline |
| BE789822A (fr) * | 1971-10-08 | 1973-04-06 | Allen & Hanburys Ltd | Nouveaux composes heterocycliques |
| BE793524A (fr) * | 1971-12-30 | 1973-06-29 | Riker Laboratories Inc | Acides benzoquinolizine-carboxyliques et leurs derives |
-
1973
- 1973-04-05 GB GB1627973A patent/GB1433151A/en not_active Expired
-
1974
- 1974-03-21 ZA ZA00741860A patent/ZA741860B/xx unknown
- 1974-03-25 IE IE649/74A patent/IE39101B1/xx unknown
- 1974-03-27 AU AU67200/74A patent/AU6720074A/en not_active Expired
- 1974-03-27 US US455071A patent/US3917608A/en not_active Expired - Lifetime
- 1974-04-01 LU LU69756A patent/LU69756A1/xx unknown
- 1974-04-01 DE DE2415763A patent/DE2415763A1/de active Pending
- 1974-04-01 BE BE142731A patent/BE813158A/xx unknown
- 1974-04-02 CH CH462974A patent/CH602722A5/xx not_active IP Right Cessation
- 1974-04-03 FR FR7411776A patent/FR2230355B1/fr not_active Expired
- 1974-04-03 AT AT277074A patent/AT330180B/de not_active IP Right Cessation
- 1974-04-05 NL NL7404719A patent/NL7404719A/xx not_active Application Discontinuation
- 1974-04-05 JP JP49039368A patent/JPS5024296A/ja active Pending
- 1974-04-05 CA CA197,107A patent/CA1015758A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA741860B (en) | 1975-02-26 |
| US3917608A (en) | 1975-11-04 |
| LU69756A1 (US07612075-20091103-C00064.png) | 1975-06-16 |
| GB1433151A (en) | 1976-04-22 |
| AU6720074A (en) | 1975-10-02 |
| ATA277074A (de) | 1975-09-15 |
| CH602722A5 (US07612075-20091103-C00064.png) | 1978-07-31 |
| AU474838B2 (US07612075-20091103-C00064.png) | 1976-08-05 |
| DE2415763A1 (de) | 1974-10-17 |
| FR2230355B1 (US07612075-20091103-C00064.png) | 1977-05-06 |
| NL7404719A (US07612075-20091103-C00064.png) | 1974-10-08 |
| IE39101B1 (en) | 1978-08-02 |
| BE813158A (fr) | 1974-10-01 |
| FR2230355A1 (US07612075-20091103-C00064.png) | 1974-12-20 |
| JPS5024296A (US07612075-20091103-C00064.png) | 1975-03-15 |
| IE39101L (en) | 1974-10-05 |
| AT330180B (de) | 1976-06-25 |
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