CA1000701A - Process for preparing hexahydrobenzo (6,7) cyclohepta(1,2,3-de)isoquinolines - Google Patents

Process for preparing hexahydrobenzo (6,7) cyclohepta(1,2,3-de)isoquinolines

Info

Publication number
CA1000701A
CA1000701A CA147,532A CA147532A CA1000701A CA 1000701 A CA1000701 A CA 1000701A CA 147532 A CA147532 A CA 147532A CA 1000701 A CA1000701 A CA 1000701A
Authority
CA
Canada
Prior art keywords
hexahydrobenzo
isoquinolines
cyclohepta
preparing
preparing hexahydrobenzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA147,532A
Other versions
CA147532S (en
Inventor
Leslie G. Humber
Francois T. Bruderlein
Chih H. Chou
Minas P. Georgiadis
Martin A. Davis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Canada Inc
Original Assignee
Ayerst Mckenna and Harrison Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ayerst Mckenna and Harrison Inc filed Critical Ayerst Mckenna and Harrison Inc
Priority to CA147,532A priority Critical patent/CA1000701A/en
Application granted granted Critical
Publication of CA1000701A publication Critical patent/CA1000701A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
CA147,532A 1972-07-19 1972-07-19 Process for preparing hexahydrobenzo (6,7) cyclohepta(1,2,3-de)isoquinolines Expired CA1000701A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA147,532A CA1000701A (en) 1972-07-19 1972-07-19 Process for preparing hexahydrobenzo (6,7) cyclohepta(1,2,3-de)isoquinolines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA147,532A CA1000701A (en) 1972-07-19 1972-07-19 Process for preparing hexahydrobenzo (6,7) cyclohepta(1,2,3-de)isoquinolines

Publications (1)

Publication Number Publication Date
CA1000701A true CA1000701A (en) 1976-11-30

Family

ID=4093888

Family Applications (1)

Application Number Title Priority Date Filing Date
CA147,532A Expired CA1000701A (en) 1972-07-19 1972-07-19 Process for preparing hexahydrobenzo (6,7) cyclohepta(1,2,3-de)isoquinolines

Country Status (1)

Country Link
CA (1) CA1000701A (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035711A2 (en) * 1980-03-08 1981-09-16 BASF Aktiengesellschaft 10-Substituted-5-cyanomethylene-dibenzo-(a,d)cycloheptenes, process for their preparation and pharmaceutical compositions containing them
EP0035714A2 (en) * 1980-03-08 1981-09-16 BASF Aktiengesellschaft 10-Substituted-5-cyanomethylene-10,11-dihydro-dibenzo-(a,d)-cycloheptenes, process for their preparation and pharmaceutical compositions containing them
US4522946A (en) * 1983-06-13 1985-06-11 Ayerst, Mckenna & Harrison, Inc. Dioxy hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline derivatives useful as neuroleptic agents
WO1999011645A1 (en) * 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Poly(adp-ribose) polymerase ('parp') inhibitors, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6291425B1 (en) * 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6306889B1 (en) 1997-09-03 2001-10-23 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6348475B1 (en) 2000-06-01 2002-02-19 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
US6380211B1 (en) 1997-09-03 2002-04-30 Guilford Pharmaceutical Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
AU2005202592B2 (en) * 1997-09-03 2008-06-19 Eisai Inc. Compounds, Methods and Pharmaceutical Compositions for Treating Cellular Damage, such as Neural or Cardiovascular Tissue Damage

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035711A2 (en) * 1980-03-08 1981-09-16 BASF Aktiengesellschaft 10-Substituted-5-cyanomethylene-dibenzo-(a,d)cycloheptenes, process for their preparation and pharmaceutical compositions containing them
EP0035714A2 (en) * 1980-03-08 1981-09-16 BASF Aktiengesellschaft 10-Substituted-5-cyanomethylene-10,11-dihydro-dibenzo-(a,d)-cycloheptenes, process for their preparation and pharmaceutical compositions containing them
EP0035714A3 (en) * 1980-03-08 1982-01-20 Basf Aktiengesellschaft 10-substituted-5-cyanomethylene-10,11-dihydro-dibenzo-(a,d)-cycloheptenes, process for their preparation and pharmaceutical compositions containing them
EP0035711A3 (en) * 1980-03-08 1982-01-20 Basf Aktiengesellschaft 10-substituted-5-cyanomethylene-dibenzo-(a,d)cycloheptenes, process for their preparation and pharmaceutical compositions containing them
US4376773A (en) 1980-03-08 1983-03-15 Basf Aktiengesellschaft 10-Substituted 5-cyanomethylene-10,11-dihydro-dibenzo-[a,d]-cycloheptenes, their preparation, and therapeutic agents containing these compounds
US4447610A (en) * 1980-03-08 1984-05-08 Basf Aktiengesellschaft 10-Substituted 5-cyanomethylene-dibenzo[A,B]-cycloheptenes, their preparations, and therapeutic agents containing these compounds
US4522946A (en) * 1983-06-13 1985-06-11 Ayerst, Mckenna & Harrison, Inc. Dioxy hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline derivatives useful as neuroleptic agents
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6306889B1 (en) 1997-09-03 2001-10-23 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
WO1999011645A1 (en) * 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Poly(adp-ribose) polymerase ('parp') inhibitors, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
AU2005202592B2 (en) * 1997-09-03 2008-06-19 Eisai Inc. Compounds, Methods and Pharmaceutical Compositions for Treating Cellular Damage, such as Neural or Cardiovascular Tissue Damage
US6380211B1 (en) 1997-09-03 2002-04-30 Guilford Pharmaceutical Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6291425B1 (en) * 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6716828B1 (en) * 1999-09-01 2004-04-06 Guilford Pharmaceuticals, Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US7307080B2 (en) 1999-09-01 2007-12-11 Mgi Gp, Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
US6348475B1 (en) 2000-06-01 2002-02-19 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout

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