BRPI0906379A2 - process for making a 6-fluoro-1,2-dihydro-2-oxo-3h-indyl-3-ylidene derivative - Google Patents

process for making a 6-fluoro-1,2-dihydro-2-oxo-3h-indyl-3-ylidene derivative

Info

Publication number
BRPI0906379A2
BRPI0906379A2 BRPI0906379A BRPI0906379A BRPI0906379A2 BR PI0906379 A2 BRPI0906379 A2 BR PI0906379A2 BR PI0906379 A BRPI0906379 A BR PI0906379A BR PI0906379 A BRPI0906379 A BR PI0906379A BR PI0906379 A2 BRPI0906379 A2 BR PI0906379A2
Authority
BR
Brazil
Prior art keywords
indyl
dihydro
oxo
fluoro
making
Prior art date
Application number
BRPI0906379A
Other languages
Portuguese (pt)
Inventor
Schnaubelt Juergen
Pfrengle Waldemar
Rall Werner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0906379A2 publication Critical patent/BRPI0906379A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0906379A 2008-01-25 2009-01-22 process for making a 6-fluoro-1,2-dihydro-2-oxo-3h-indyl-3-ylidene derivative BRPI0906379A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150661 2008-01-25
PCT/EP2009/000377 WO2009092580A1 (en) 2008-01-25 2009-01-22 Process for the manufacture of a 6-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene derivative

Publications (1)

Publication Number Publication Date
BRPI0906379A2 true BRPI0906379A2 (en) 2019-09-24

Family

ID=40419005

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0906379A BRPI0906379A2 (en) 2008-01-25 2009-01-22 process for making a 6-fluoro-1,2-dihydro-2-oxo-3h-indyl-3-ylidene derivative

Country Status (14)

Country Link
US (1) US20110046395A1 (en)
EP (1) EP2238107A1 (en)
JP (1) JP2011510031A (en)
KR (1) KR20100114103A (en)
CN (1) CN101970407A (en)
AU (1) AU2009207861A1 (en)
BR (1) BRPI0906379A2 (en)
CA (1) CA2712385A1 (en)
IL (1) IL206886A0 (en)
MX (1) MX2010007949A (en)
NZ (1) NZ586760A (en)
RU (1) RU2010135196A (en)
WO (1) WO2009092580A1 (en)
ZA (1) ZA201004757B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104844499B (en) * 2015-06-05 2017-03-08 北京康立生医药技术开发有限公司 One kettle way prepares the synthetic method of Nintedanib
CN115960030B (en) * 2023-01-10 2024-09-27 湖北工业大学 Preparation method of 3-subunit oxindole derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10233366A1 (en) * 2002-07-23 2004-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
PE20040701A1 (en) * 2002-07-23 2004-11-30 Boehringer Ingelheim Pharma INDOLINONE DERIVATIVES SUBSTITUTED IN POSITION 6 AND THEIR PREPARATION AS MEDICINES
DE102004012070A1 (en) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments
DE102004012068A1 (en) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New alkyl-containing 5-acylindolinones, their preparation and their use as pharmaceuticals
JP2009533480A (en) * 2006-04-24 2009-09-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 3- (Aminomethylidene) 2-indolinone derivatives and their use as cytostatics
ES2394239T3 (en) * 2008-01-25 2013-01-23 Boehringer Ingelheim International Gmbh Salt forms of a 6-fluoro-1,2-dihydro-2-oxo-3H-indole-3-ylidene derivative, preparation process and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR20100114103A (en) 2010-10-22
RU2010135196A (en) 2012-02-27
IL206886A0 (en) 2010-12-30
US20110046395A1 (en) 2011-02-24
MX2010007949A (en) 2010-08-04
EP2238107A1 (en) 2010-10-13
WO2009092580A1 (en) 2009-07-30
NZ586760A (en) 2011-12-22
ZA201004757B (en) 2011-03-30
AU2009207861A1 (en) 2009-07-30
CN101970407A (en) 2011-02-09
JP2011510031A (en) 2011-03-31
CA2712385A1 (en) 2009-07-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.