BRPI0820698A2 - 4-imidazolidinonas como inibidores de canal de potássio kv1.5 - Google Patents

4-imidazolidinonas como inibidores de canal de potássio kv1.5

Info

Publication number
BRPI0820698A2
BRPI0820698A2 BRPI0820698A BRPI0820698A BRPI0820698A2 BR PI0820698 A2 BRPI0820698 A2 BR PI0820698A2 BR PI0820698 A BRPI0820698 A BR PI0820698A BR PI0820698 A BRPI0820698 A BR PI0820698A BR PI0820698 A2 BRPI0820698 A2 BR PI0820698A2
Authority
BR
Brazil
Prior art keywords
imidazolidinones
potassium channel
channel inhibitors
inhibitors
potassium
Prior art date
Application number
BRPI0820698A
Other languages
English (en)
Inventor
J Fluxe Andrew
E Blass Benjamin
m jackson Christopher
M Ridgeway Ii James
M Janusz John
Coburn Keith
Fairweather Neil
E White Ronald
Wu Shengde
Lee Wenlin
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI0820698A2 publication Critical patent/BRPI0820698A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
BRPI0820698A 2007-12-19 2008-12-18 4-imidazolidinonas como inibidores de canal de potássio kv1.5 BRPI0820698A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1493707P 2007-12-19 2007-12-19
US1550507P 2007-12-20 2007-12-20
PCT/US2008/087397 WO2009079624A1 (en) 2007-12-19 2008-12-18 4-imidazolidinones as kv1.5 potassium channel inhibitors

Publications (1)

Publication Number Publication Date
BRPI0820698A2 true BRPI0820698A2 (pt) 2019-09-24

Family

ID=40377353

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820698A BRPI0820698A2 (pt) 2007-12-19 2008-12-18 4-imidazolidinonas como inibidores de canal de potássio kv1.5

Country Status (7)

Country Link
EP (1) EP2234615A1 (pt)
JP (1) JP2011507883A (pt)
AU (1) AU2008338368A1 (pt)
BR (1) BRPI0820698A2 (pt)
CA (1) CA2709186A1 (pt)
WO (1) WO2009079624A1 (pt)
ZA (1) ZA201005087B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO3175985T3 (pt) 2011-07-01 2018-04-28
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
EP3154934B1 (en) 2014-06-16 2021-04-14 Université de Lille Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts DIRECTED AND RECORDED COMBINATORY SYNTHESIS OF OLIGONUCLEOTIDES OF CODED PROBE MOLECULES
GB2557931A (en) * 2016-12-16 2018-07-04 Univ Bristol Unnatural amino acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3442892A (en) * 1965-06-11 1969-05-06 Nippon Shinyaku Co Ltd Imidazolidinone derivatives
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
AU2007260984A1 (en) * 2006-06-20 2007-12-27 Wyeth Kv1.5 potassium channel inhibitors

Also Published As

Publication number Publication date
AU2008338368A1 (en) 2009-06-25
JP2011507883A (ja) 2011-03-10
ZA201005087B (en) 2011-03-30
WO2009079624A1 (en) 2009-06-25
EP2234615A1 (en) 2010-10-06
CA2709186A1 (en) 2009-06-25

Similar Documents

Publication Publication Date Title
BRPI0816786A2 (pt) Canal
BRPI0815717A2 (pt) Compostos de imidazopirazina.
ATE461177T1 (de) Ionenkanal-hemmer
BRPI0719499A2 (pt) Composições de poliolefina
BRPI0809690A2 (pt) Composição de lubrificante, e, método
CL2008000649S1 (es) Banda de rodadura.
ATE513831T1 (de) Pyridinä3,4-büpyrazinone
BRPI0814466A2 (pt) Método.
BRPI0813235A2 (pt) Combinação anti-helmíntica.
BRPI0818380A2 (pt) Combinação de herbicida-protetor
BRPI0915731A2 (pt) composição de graxa.
BRPI0915732A2 (pt) composição de graxa.
BRPI0918290A2 (pt) reforço com design de canal
BRPI0818800A2 (pt) Protease de streptomyces
BRPI0811044A2 (pt) 2-morfolin-4-il-pirimidinas como inibidores de p13k.
BRPI0813245A2 (pt) Escova de dentes.
BRPI0822587A2 (pt) Sistema de canal
FI20065755A0 (fi) Kanavan estimointi
BRPI0806970A2 (pt) Compostos e composições como inibidores de protease de ativação de canal
FI20065180A0 (fi) Kanavan laadun osoittimen lähettäminen
BRPI0917446A2 (pt) derivados de acilaminobenzamida.
FR2928371B1 (fr) Derive de cysteine.
BRPI0813867A2 (pt) Composições compreendendo inibidores e hidrolase de triptofano.
BRPI0906714A2 (pt) Derivados de oxazepinopirimidona heteroarilamida substituídos.
BRPI0814748A2 (pt) Compostos de alditóis substituídos, composições e métodos

Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.