BRPI0802661A2 - slow release hormone progesterone device used in bovine females - Google Patents

Abstract

VAGINAL DEVICE FOR SLOW RELEASE OF PROGESTERONE (HORMONE) USED IN BOVINE FEMALE. Which synchronizes the heat and ovulation of these animals, enabling reproductive programs such as fixed-time artificial insemination, superovulation and receptor synchronization, among others, having a "T" shape, with a plastic tail for its extraction, and consisting of a nylon plastic core (insert) that gives it strength and stiffness, and this core is completely covered with a silicone membrane, about 1.9mm thick with progesterone impregnated, and this membrane is responsible for the slow release of the hormone, said The insert is produced by thermal injection of polyamide into steel molds and the inserts are subsequently allocated to a new mold, where they receive the progesterone impregnated silicone layer. this new processing being performed by transfer mold injection of the mixture of a hot cure silicone liquid elastomer with progesterone. so that the final product contains 1 g of progesterone.

Description

"VAGINAL PRODUCT SLOW PARALIBERATION OF PROGESTERONE (HORMONE) USED IN BOVINE FEMALE"

This invention is a patent for the Invention of Vaginal Device for Slow Release of Progesterone (Hormone) Used in Female Bovines, with the purpose of synchronizing the estrus and movements of these animals, enabling reproductive programs such as fixed time artificial insemination, superovulation and dereceptor synchronization, among others.

The product has a "T" shape with a plastic tail for its extraction. It is composed of a denylon plastic core (insert) that gives it strength and rigidity, being totally covered with a silicone membrane, about 1.9mm. of progesterone-impregnated thickness.This membrane is responsible for the slow release of hormone.

Said insert is produced by thermal injection of polyamide into steel molds. The inserts are then allocated1 in a new mold where they receive the impregnated silicone layer of progesterone, which is further processed by injection molding to transfer the mixture of a hot cure silicone elastomer such as progesterone so that the final product contains 1g progesterone.

Figure 1 is a front view of the product. Numerical references indicate: (1) nylon plastic core (insert), (2) progesterone impregnated silicone membrane (sheath).

Figure 2 represents a top view of the product.

Figure 3 is a side view of the product. Figure 4 is a cross-sectional view of a plane indicated by line A-A in Figure 1.

The object of the present patent is the first intravaginal progesterone device in Brazil. This product was developed based on the latest knowledge of reproductive physiology and the needs of the national herd. It has innovative features that differ from imported products available in the market.

Main advantages:

1. Safety of Use All raw materials used in the manufacture of the product are approved by the US FDA. Thus, the core is made of proven inert material, safe even for use in food packaging and silicone approved for human use. In addition, the product was released by the Brazilian Ministry of Agriculture, Livestock and Supply, for use in lactating cows without discarding milk during treatment.

2. Special Anatomical Features

The intravaginal progesterone device has been developed with softer silicone, which ensures greater comfort to the treated females. Its plastic core has been developed with the latest engineering concepts, providing excellent fixation even during reuse.

3. Greater practicality of application

The applicator of the product is thin and long, which ensures ease of introduction and comfort for the female. Mounting the device on the applicator is practical and quick. In addition, the applicator has an exclusive safety lock that prevents the device from being released before reaching the bottom of the vagina, avoiding the loss of devices during treatment protocols as much as possible.4. Adequate Progesterone Dose

The device was developed from the most modern concepts of bovine endocrinology. Current experiments have shown that excessive release of progesterone by high dose devices impairs follicular growth and ovulation, especially in zebu heifers. The product contains the most appropriate dose (one gram deprogesterone per device), ensuring excellent results in any animal category (cows and heifers).

5. Cost - Benefit

In addition to all the advantages mentioned above, the product enables a great cost of reproductive programs, making them more accessible to Brazilian ranchers.

Claims (2)

1.) "VAGINAL DEVICE SLOW PARALIBERATION OF PROGESTERONE (HORMONE) USED IN BOVINE FEMALES", characterized by synchronizing the estrus and ovulation of these animals, enabling reproductive programs such as fixed time artificial insemination, superovulation and dereceptor synchronization, among others, having a "T", with a plastic tail for its extraction, and consisting of a nylon plastic core (insert) that gives it strength and rigidity, being fully covered with a silicone membrane, about 1.9mm thick impregnated with polyesterone. , this membrane being responsible for the slow release of the hormone. 2.) "PROGESTERONE (HORMONE) SLOW PARALIBERATION VAGINAL DEVICE USED IN BOVINE FEMALS" according to Claim I, characterized in that said insert is produced by thermal injection of polyamide in steel molds and the inserts are subsequently allocated to a new mold. , where they receive the progesterone-impregnated silicone layer, this new processing being performed by transfer mold injection of the mixture of a hot cured silicone elastomer with oprogesterone, so that the final product contains progesterone Ig.