BRPI0713582A2 - derivados de fenilpentadienoìla e seu uso como antagonistas de par um - Google Patents
derivados de fenilpentadienoìla e seu uso como antagonistas de par um Download PDFInfo
- Publication number
- BRPI0713582A2 BRPI0713582A2 BRPI0713582-3A BRPI0713582A BRPI0713582A2 BR PI0713582 A2 BRPI0713582 A2 BR PI0713582A2 BR PI0713582 A BRPI0713582 A BR PI0713582A BR PI0713582 A2 BRPI0713582 A2 BR PI0713582A2
- Authority
- BR
- Brazil
- Prior art keywords
- phenyl
- penta
- piperazin
- dien
- formula
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract description 4
- BCRJHHFLBOQAMG-UHFFFAOYSA-N penta-1,3-dienylbenzene Chemical class CC=CC=CC1=CC=CC=C1 BCRJHHFLBOQAMG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 63
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 13
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 9
- 150000002367 halogens Chemical class 0.000 claims abstract description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
- 239000001257 hydrogen Substances 0.000 claims abstract description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
- 239000012453 solvate Substances 0.000 claims abstract description 6
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims abstract 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical group C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims abstract 2
- KAVSMINTEBGDTI-UHFFFAOYSA-N pyridine;thiophene Chemical group C=1C=CSC=1.C1=CC=NC=C1 KAVSMINTEBGDTI-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 37
- 239000000047 product Substances 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 17
- -1 4-Cyclohexyl-piperazin-1-yl Chemical group 0.000 claims description 15
- 150000001412 amines Chemical class 0.000 claims description 14
- 229940098892 Protease-activated receptor-1 antagonist Drugs 0.000 claims description 12
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 12
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- 239000003814 drug Substances 0.000 claims description 11
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- 229910052740 iodine Inorganic materials 0.000 claims description 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
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- 150000002431 hydrogen Chemical class 0.000 claims description 5
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- 125000006239 protecting group Chemical group 0.000 claims description 4
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- RWAGJRSRCSOWHV-UHFFFAOYSA-N 5-(2,6-difluorophenyl)-1-(4-phenylpiperazin-1-yl)penta-2,4-dien-1-one Chemical compound FC1=CC=CC(F)=C1C=CC=CC(=O)N1CCN(C=2C=CC=CC=2)CC1 RWAGJRSRCSOWHV-UHFFFAOYSA-N 0.000 claims description 3
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- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 3
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- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
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- GDMFQEYMRVQWAD-UHFFFAOYSA-N 2-[5-oxo-5-(4-pyridin-2-ylpiperazin-1-yl)penta-1,3-dienyl]benzonitrile Chemical compound C1CN(C=2N=CC=CC=2)CCN1C(=O)C=CC=CC1=CC=CC=C1C#N GDMFQEYMRVQWAD-UHFFFAOYSA-N 0.000 claims description 2
- LWOVQLFJUFSKKR-UHFFFAOYSA-N 5-(2-chlorophenyl)-1-(4-cyclopentylpiperazin-1-yl)penta-2,4-dien-1-one Chemical compound ClC1=CC=CC=C1C=CC=CC(=O)N1CCN(C2CCCC2)CC1 LWOVQLFJUFSKKR-UHFFFAOYSA-N 0.000 claims description 2
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims description 2
- 239000005528 B01AC05 - Ticlopidine Substances 0.000 claims description 2
- 108010056764 Eptifibatide Proteins 0.000 claims description 2
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- 206010047249 Venous thrombosis Diseases 0.000 claims description 2
- 229960000446 abciximab Drugs 0.000 claims description 2
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims description 2
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- 239000013066 combination product Substances 0.000 claims description 2
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 238000010511 deprotection reaction Methods 0.000 claims description 2
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- 229960004468 eptifibatide Drugs 0.000 claims description 2
- GLGOPUHVAZCPRB-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CN=C2[C]1C=CC=C2 GLGOPUHVAZCPRB-LROMGURASA-N 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 230000002035 prolonged effect Effects 0.000 claims description 2
- 230000033764 rhythmic process Effects 0.000 claims description 2
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 claims description 2
- 229960005001 ticlopidine Drugs 0.000 claims description 2
- 229960003425 tirofiban Drugs 0.000 claims description 2
- COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 claims description 2
- VIYJOYNKGXZRKW-UHFFFAOYSA-N 1-(4-butylpiperazin-1-yl)-5-(2-nitrophenyl)penta-2,4-dien-1-one Chemical compound C1CN(CCCC)CCN1C(=O)C=CC=CC1=CC=CC=C1[N+]([O-])=O VIYJOYNKGXZRKW-UHFFFAOYSA-N 0.000 claims 1
- MULCNWFWOQIAOK-UHFFFAOYSA-N 1-(4-cyclohexylpiperazin-1-yl)-5-(2,6-difluorophenyl)penta-2,4-dien-1-one Chemical compound FC1=CC=CC(F)=C1C=CC=CC(=O)N1CCN(C2CCCCC2)CC1 MULCNWFWOQIAOK-UHFFFAOYSA-N 0.000 claims 1
- XCKKENKKNBFFSM-UHFFFAOYSA-N 1-(4-cyclohexylpiperazin-1-yl)-5-(2-fluorophenyl)penta-2,4-dien-1-one Chemical compound FC1=CC=CC=C1C=CC=CC(=O)N1CCN(C2CCCCC2)CC1 XCKKENKKNBFFSM-UHFFFAOYSA-N 0.000 claims 1
- SAJBTFAPFJTUMT-UHFFFAOYSA-N 1-(4-cyclohexylpiperazin-1-yl)-5-(2-nitrophenyl)penta-2,4-dien-1-one Chemical compound [O-][N+](=O)C1=CC=CC=C1C=CC=CC(=O)N1CCN(C2CCCCC2)CC1 SAJBTFAPFJTUMT-UHFFFAOYSA-N 0.000 claims 1
- BSUOPQDAPWBOFZ-UHFFFAOYSA-N 1-(4-cyclopentylpiperazin-1-yl)-5-(2,6-difluorophenyl)penta-2,4-dien-1-one Chemical compound FC1=CC=CC(F)=C1C=CC=CC(=O)N1CCN(C2CCCC2)CC1 BSUOPQDAPWBOFZ-UHFFFAOYSA-N 0.000 claims 1
- NHJKEXDXBUKOIQ-UHFFFAOYSA-N 1-(4-cyclopentylpiperazin-1-yl)-5-(2-nitrophenyl)penta-2,4-dien-1-one Chemical compound [O-][N+](=O)C1=CC=CC=C1C=CC=CC(=O)N1CCN(C2CCCC2)CC1 NHJKEXDXBUKOIQ-UHFFFAOYSA-N 0.000 claims 1
- ILNSDBAEPQSNFQ-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)piperazin-1-yl]-5-(2-nitrophenyl)penta-2,4-dien-1-one Chemical compound [O-][N+](=O)C1=CC=CC=C1C=CC=CC(=O)N1CCN(C=2C=C(Cl)C=CC=2)CC1 ILNSDBAEPQSNFQ-UHFFFAOYSA-N 0.000 claims 1
- SSCCADCLSFMOBL-UHFFFAOYSA-N 1-[4-(3-chloropropyl)piperazin-1-yl]-5-(2,6-difluorophenyl)penta-2,4-dien-1-one Chemical compound FC1=CC=CC(F)=C1C=CC=CC(=O)N1CCN(CCCCl)CC1 SSCCADCLSFMOBL-UHFFFAOYSA-N 0.000 claims 1
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- KLKOJWGACZECEJ-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)piperazin-1-yl]-5-(2-nitrophenyl)penta-2,4-dien-1-one Chemical compound [O-][N+](=O)C1=CC=CC=C1C=CC=CC(=O)N1CCN(C=2C=CC(F)=CC=2)CC1 KLKOJWGACZECEJ-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0605418 | 2006-06-19 | ||
| FR0605418A FR2902427B1 (fr) | 2006-06-19 | 2006-06-19 | Derives de phenylpentadienoyle |
| PCT/EP2007/056078 WO2007147822A1 (en) | 2006-06-19 | 2007-06-19 | Phenylpentadienoyl derivatives and their use as par 1 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0713582A2 true BRPI0713582A2 (pt) | 2012-10-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| BRPI0713582-3A BRPI0713582A2 (pt) | 2006-06-19 | 2007-06-19 | derivados de fenilpentadienoìla e seu uso como antagonistas de par um |
Country Status (24)
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| EP (1) | EP2046748B1 (enExample) |
| JP (1) | JP5268897B2 (enExample) |
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| AU (1) | AU2007263049B2 (enExample) |
| BR (1) | BRPI0713582A2 (enExample) |
| CA (1) | CA2655728A1 (enExample) |
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| UA (1) | UA97370C2 (enExample) |
| WO (1) | WO2007147822A1 (enExample) |
| ZA (1) | ZA200810629B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104496879A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 一种含腈基苯和二烯氟代金刚烷结构的化合物和用途 |
| US20200157048A1 (en) * | 2018-03-27 | 2020-05-21 | Bioway., Inc | (2e,4e)-5-phenyl-penta-2,4-dien-1-one derivative |
| CN118852057B (zh) * | 2024-05-29 | 2025-09-26 | 赣南医科大学 | 胡椒碱或其衍生物的应用 |
Family Cites Families (5)
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| JPS61106564A (ja) * | 1984-10-30 | 1986-05-24 | Terumo Corp | 不飽和脂肪酸アミド誘導体およびこれを含有する血小板凝集抑制剤 |
| JPS61137866A (ja) * | 1984-12-07 | 1986-06-25 | Terumo Corp | イミダゾ−ル誘導体およびこれを含有する血小板凝集抑制剤 |
| US4792553A (en) * | 1986-02-04 | 1988-12-20 | Terumo Kabushiki Kaisha | Diene derivatives and vasodilators containing the same |
| HK1049004A1 (en) * | 2000-01-20 | 2003-04-25 | Eisai Co., Ltd. | Nitrogenous cyclic compounds and pharmaceutical compositions containing the same |
| FR2917622B1 (fr) * | 2007-06-19 | 2009-10-23 | Pierre Fabre Medicament Sa | Utilisation d'un antagoniste par1 dans le traitement de la fibrillation atriale. |
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2006
- 2006-06-19 FR FR0605418A patent/FR2902427B1/fr not_active Expired - Fee Related
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2007
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- 2007-06-19 WO PCT/EP2007/056078 patent/WO2007147822A1/en not_active Ceased
- 2007-06-19 BR BRPI0713582-3A patent/BRPI0713582A2/pt not_active Application Discontinuation
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- 2007-06-19 ES ES07765492T patent/ES2361061T3/es active Active
- 2007-06-19 AT AT07765492T patent/ATE500223T1/de not_active IP Right Cessation
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- 2007-06-19 CA CA002655728A patent/CA2655728A1/en not_active Abandoned
- 2007-06-19 UA UAA200900375A patent/UA97370C2/ru unknown
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- 2007-06-19 AR ARP070102684A patent/AR061519A1/es not_active Application Discontinuation
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- 2008-12-18 MA MA31483A patent/MA31131B1/fr unknown
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2007263049A1 (en) | 2007-12-27 |
| CA2655728A1 (en) | 2007-12-27 |
| DE602007012888D1 (de) | 2011-04-14 |
| ES2361061T3 (es) | 2011-06-13 |
| IL195869A0 (en) | 2009-09-01 |
| FR2902427A1 (fr) | 2007-12-21 |
| EP2046748A1 (en) | 2009-04-15 |
| CN101472894B (zh) | 2012-09-05 |
| EP2046748B1 (en) | 2011-03-02 |
| JP5268897B2 (ja) | 2013-08-21 |
| AR061519A1 (es) | 2008-09-03 |
| UA97370C2 (ru) | 2012-02-10 |
| CN101472894A (zh) | 2009-07-01 |
| WO2007147822A1 (en) | 2007-12-27 |
| NZ573591A (en) | 2010-10-29 |
| TW200815371A (en) | 2008-04-01 |
| FR2902427B1 (fr) | 2008-08-22 |
| RU2440985C2 (ru) | 2012-01-27 |
| JP2009541258A (ja) | 2009-11-26 |
| MX2008016446A (es) | 2009-01-22 |
| US8022064B2 (en) | 2011-09-20 |
| ZA200810629B (en) | 2010-02-24 |
| RU2008149917A (ru) | 2010-07-27 |
| ATE500223T1 (de) | 2011-03-15 |
| MA31131B1 (fr) | 2010-02-01 |
| NO20090269L (no) | 2009-02-27 |
| TNSN08521A1 (en) | 2010-04-14 |
| KR20090031735A (ko) | 2009-03-27 |
| AU2007263049B2 (en) | 2011-10-27 |
| US20100003260A1 (en) | 2010-01-07 |
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| CN102149682B (zh) | 1-(取代芳基)-5-三氟甲基-2-（1h）吡啶酮化合物及其盐的制备方法及其用途 | |
| BRPI0713582A2 (pt) | derivados de fenilpentadienoìla e seu uso como antagonistas de par um | |
| HK1129385A (en) | Phenylpentadienoyl derivatives and their use as par 1 antagonists | |
| HK1127353B (en) | Cinnamoyl-piperazine derivatives and their use as par- i antagonists |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |