BRPI0704450A2 - process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt - Google Patents
process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt Download PDFInfo
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- BRPI0704450A2 BRPI0704450A2 BRPI0704450A BRPI0704450A2 BR PI0704450 A2 BRPI0704450 A2 BR PI0704450A2 BR PI0704450 A BRPI0704450 A BR PI0704450A BR PI0704450 A2 BRPI0704450 A2 BR PI0704450A2
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- phosphonoxy
- diphenyl
- methyl
- product
- preparing
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Abstract
PROCESSO PARA PREPARAçãO DO SAL DISóDICO DO 5,5-DIFENIL-[(3-FOSFONOXI) METIL]-2,4-JMIDAZOLIDINEDlONA. A preparação da fosfenitoína disódica a partir do ácido fosfórico dibenzil éster 2,5-dioxo-4.4-difenil-imidazolidin-1-ilmetil éster ocorre através da utilização de agentes de transferência catalítica de hidrogênio, preferencialmente formiato de sódio, obtendo-se uma fase orgânica com o produto e subprodutos, os quais são adequadamente separados do solvente orgânico com precipitação do produto e redissolução em água que tem seu pH ajustado com solução aquosa de um ácido orgânico até pH na faixa de 8 a 9 sendo então obtido o produto fosfenitoína disódica que e separado de contaminantes por refrigeração da mistura reacional e isolado por filtração.PROCESS FOR PREPARATION OF 5,5-DIPHYL - [(3-PHOSPHONOXY) METHYL] -2,4-JMIDAZOLIDINEDLONE DISODIC SALT. The preparation of disodium phosphenytoin from dibenzyl ester 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl ester occurs through the use of hydrogen catalytic transfer agents, preferably sodium formate, to obtain a phase. with the product and by-products, which are suitably separated from the organic solvent with precipitation of the product and redissolution in water which has its pH adjusted with aqueous solution of an organic acid to pH in the range of 8 to 9 and then the disodium phosphenytoin product is obtained. which is separated from contaminants by refrigeration of the reaction mixture and isolated by filtration.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0704450 BRPI0704450A2 (en) | 2007-11-30 | 2007-11-30 | process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0704450 BRPI0704450A2 (en) | 2007-11-30 | 2007-11-30 | process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0704450A2 true BRPI0704450A2 (en) | 2012-03-20 |
Family
ID=45816304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0704450 BRPI0704450A2 (en) | 2007-11-30 | 2007-11-30 | process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt |
Country Status (1)
Country | Link |
---|---|
BR (1) | BRPI0704450A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014180264A1 (en) * | 2013-05-10 | 2014-11-13 | 安徽省先锋制药有限公司 | Stable organic amine salt of fosphenytoin and preparation method and use thereof |
-
2007
- 2007-11-30 BR BRPI0704450 patent/BRPI0704450A2/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014180264A1 (en) * | 2013-05-10 | 2014-11-13 | 安徽省先锋制药有限公司 | Stable organic amine salt of fosphenytoin and preparation method and use thereof |
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