BRPI0704450A2 - process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt - Google Patents

process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt Download PDF

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Publication number
BRPI0704450A2
BRPI0704450A2 BRPI0704450A BRPI0704450A2 BR PI0704450 A2 BRPI0704450 A2 BR PI0704450A2 BR PI0704450 A BRPI0704450 A BR PI0704450A BR PI0704450 A2 BRPI0704450 A2 BR PI0704450A2
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BR
Brazil
Prior art keywords
phosphonoxy
diphenyl
methyl
product
preparing
Prior art date
Application number
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Portuguese (pt)
Inventor
Falomir Pedraza Yubero Campo Sergio
Vianna De Carvalho Otavio
De Lima Muniz Silvia
Vitor Inacio Dos Santos João
Pereira Dos Santos Andréa
Cesar Soalheiro Alexandrino Da Cruz Marcus
Augusto Ceva Antunes Octavio
Original Assignee
Nortec Química S.a.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Nortec Química S.a. filed Critical Nortec Química S.a.
Priority to BRPI0704450 priority Critical patent/BRPI0704450A2/en
Publication of BRPI0704450A2 publication Critical patent/BRPI0704450A2/en

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Abstract

PROCESSO PARA PREPARAçãO DO SAL DISóDICO DO 5,5-DIFENIL-[(3-FOSFONOXI) METIL]-2,4-JMIDAZOLIDINEDlONA. A preparação da fosfenitoína disódica a partir do ácido fosfórico dibenzil éster 2,5-dioxo-4.4-difenil-imidazolidin-1-ilmetil éster ocorre através da utilização de agentes de transferência catalítica de hidrogênio, preferencialmente formiato de sódio, obtendo-se uma fase orgânica com o produto e subprodutos, os quais são adequadamente separados do solvente orgânico com precipitação do produto e redissolução em água que tem seu pH ajustado com solução aquosa de um ácido orgânico até pH na faixa de 8 a 9 sendo então obtido o produto fosfenitoína disódica que e separado de contaminantes por refrigeração da mistura reacional e isolado por filtração.PROCESS FOR PREPARATION OF 5,5-DIPHYL - [(3-PHOSPHONOXY) METHYL] -2,4-JMIDAZOLIDINEDLONE DISODIC SALT. The preparation of disodium phosphenytoin from dibenzyl ester 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl ester occurs through the use of hydrogen catalytic transfer agents, preferably sodium formate, to obtain a phase. with the product and by-products, which are suitably separated from the organic solvent with precipitation of the product and redissolution in water which has its pH adjusted with aqueous solution of an organic acid to pH in the range of 8 to 9 and then the disodium phosphenytoin product is obtained. which is separated from contaminants by refrigeration of the reaction mixture and isolated by filtration.

BRPI0704450 2007-11-30 2007-11-30 process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt BRPI0704450A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BRPI0704450 BRPI0704450A2 (en) 2007-11-30 2007-11-30 process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0704450 BRPI0704450A2 (en) 2007-11-30 2007-11-30 process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt

Publications (1)

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BRPI0704450A2 true BRPI0704450A2 (en) 2012-03-20

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ID=45816304

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0704450 BRPI0704450A2 (en) 2007-11-30 2007-11-30 process for preparing 5,5-diphenyl - [(3-phosphonoxy) methyl] -2,4-imidazolidinedione disodium salt

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BR (1) BRPI0704450A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014180264A1 (en) * 2013-05-10 2014-11-13 安徽省先锋制药有限公司 Stable organic amine salt of fosphenytoin and preparation method and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014180264A1 (en) * 2013-05-10 2014-11-13 安徽省先锋制药有限公司 Stable organic amine salt of fosphenytoin and preparation method and use thereof

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B03A Publication of an application: publication of a patent application or of a certificate of addition of invention
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

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