BRPI0605212B8 - production process of dimerized or oligomerized endostatin, dimerized or oligomerized endostatin and pharmaceutical composition - Google Patents

production process of dimerized or oligomerized endostatin, dimerized or oligomerized endostatin and pharmaceutical composition

Info

Publication number
BRPI0605212B8
BRPI0605212B8 BRPI0605212A BRPI0605212A BRPI0605212B8 BR PI0605212 B8 BRPI0605212 B8 BR PI0605212B8 BR PI0605212 A BRPI0605212 A BR PI0605212A BR PI0605212 A BRPI0605212 A BR PI0605212A BR PI0605212 B8 BRPI0605212 B8 BR PI0605212B8
Authority
BR
Brazil
Prior art keywords
endostatin
dimerized
oligomerized
pharmaceutical composition
production process
Prior art date
Application number
BRPI0605212A
Other languages
Portuguese (pt)
Inventor
Limaverde Soares Costa Sousa Gabriel
Geraldo Pascutti Pedro
Lobo Coelho De Sampaio Tatiana
Original Assignee
Univ Rio De Janeiro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rio De Janeiro filed Critical Univ Rio De Janeiro
Priority to BRPI0605212A priority Critical patent/BRPI0605212B8/en
Priority to PCT/BR2007/000336 priority patent/WO2008070943A2/en
Publication of BRPI0605212A publication Critical patent/BRPI0605212A/en
Publication of BRPI0605212B1 publication Critical patent/BRPI0605212B1/en
Publication of BRPI0605212B8 publication Critical patent/BRPI0605212B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

processo de produção de endostatina dimerizada ou oligomerizada, endostatina dimerizada ou oligomerizada e composição farmacêutica apresente invenção está relacionada à preparação de endostatina para o tratamento de câncer pela sua capacidade de regredir formação de vasos sangüíneos de um tumor pré-estabelecido. mais especificamente,a presente invenção está relacionada à preparação de endostatina naturalmente dimerizada ou oligomérica, formada pela associação não covalente entre subunidades da proteínas, apresentada na forma solúvel e sendo de fácil aplicação clinica.process for the production of dimerized or oligomerized endostatin, dimerized or oligomerized endostatin and pharmaceutical composition The present invention is related to the preparation of endostatin for the treatment of cancer by its ability to regress the formation of blood vessels of a pre-established tumor. more specifically, the present invention is related to the preparation of naturally dimerized or oligomeric endostatin, formed by the non-covalent association between protein subunits, presented in soluble form and being of easy clinical application.

BRPI0605212A 2006-12-12 2006-12-12 production process of dimerized or oligomerized endostatin, dimerized or oligomerized endostatin and pharmaceutical composition BRPI0605212B8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0605212A BRPI0605212B8 (en) 2006-12-12 2006-12-12 production process of dimerized or oligomerized endostatin, dimerized or oligomerized endostatin and pharmaceutical composition
PCT/BR2007/000336 WO2008070943A2 (en) 2006-12-12 2007-12-12 Process for the production of dimerized or oligomerized endostatine, dimerized or oligomerized endostatine and pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0605212A BRPI0605212B8 (en) 2006-12-12 2006-12-12 production process of dimerized or oligomerized endostatin, dimerized or oligomerized endostatin and pharmaceutical composition

Publications (3)

Publication Number Publication Date
BRPI0605212A BRPI0605212A (en) 2008-08-05
BRPI0605212B1 BRPI0605212B1 (en) 2020-12-29
BRPI0605212B8 true BRPI0605212B8 (en) 2021-05-25

Family

ID=39512121

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0605212A BRPI0605212B8 (en) 2006-12-12 2006-12-12 production process of dimerized or oligomerized endostatin, dimerized or oligomerized endostatin and pharmaceutical composition

Country Status (2)

Country Link
BR (1) BRPI0605212B8 (en)
WO (1) WO2008070943A2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653098B1 (en) * 1998-02-23 2003-11-25 G. D. Searle & Co. Method of producing mouse and human endostatin
JP2002517186A (en) * 1998-06-03 2002-06-18 ザ チルドレンズ メディカル センター コーポレイション Protein oligomer compositions containing endostatin proteins and methods of using the same

Also Published As

Publication number Publication date
WO2008070943A2 (en) 2008-06-19
WO2008070943A3 (en) 2011-04-28
BRPI0605212B1 (en) 2020-12-29
BRPI0605212A (en) 2008-08-05

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 8A E 9A ANUIDADES.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/12/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF