BRPI0516372A - multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine - Google Patents

multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Info

Publication number
BRPI0516372A
BRPI0516372A BRPI0516372-2A BRPI0516372A BRPI0516372A BR PI0516372 A BRPI0516372 A BR PI0516372A BR PI0516372 A BRPI0516372 A BR PI0516372A BR PI0516372 A BRPI0516372 A BR PI0516372A
Authority
BR
Brazil
Prior art keywords
protein conjugates
derivatized
polysaccharide
vaccine
conjugates
Prior art date
Application number
BRPI0516372-2A
Other languages
Portuguese (pt)
Inventor
Robert P Ryall
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Publication of BRPI0516372A publication Critical patent/BRPI0516372A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

CONJUGADOS DE POLISSACARìDEO-PROTEìNA DERIVATIZADOS MENINGOCóCICOS MULTIVALENTES E VACINA. A presente invenção refere-se conjugados de polissacarídeo-proteína derivatizados, uma composição compreendendo um ou mais de tais conjugados de polissacarídeo-proteína derivatizados e métodos de imunização de pacientes humanos com os mesmos. Os conjugados de polissacarídeo-proteína derivatizados são polissacarídeos capsulares purificados de Neisseria meningitidis sorogrupos A, C, W-1 35 e/ou Y, derivatizados quimicamente ativados e seletivamente ligados a uma proteína carreadora por meio de uma ligação química covalente, formando conjugados de polissacarídeo-proteína capazes de elicitar imunidade de longa duração para uma variedade de cepas de N. meningitidis.MULTIVALENT MENINGOCOCIC DERIVATIZED POLYSACARIDE PROTEIN CONJUGATES AND VACCINE. The present invention relates to derivatized polysaccharide-protein conjugates, a composition comprising one or more such derivatized polysaccharide-protein conjugates and methods of immunizing human patients with them. Derivatized polysaccharide-protein conjugates are purified capsular polysaccharides of Neisseria meningitidis serogroups A, C, W-1 35 and / or Y, chemically activated derivatized and selectively linked to a carrier protein by covalent chemical bonding, forming polysaccharide conjugates. -proteins capable of eliciting long-term immunity to a variety of N. meningitidis strains.

BRPI0516372-2A 2005-12-22 2005-12-22 multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine BRPI0516372A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/046886 WO2007102797A2 (en) 2005-12-22 2005-12-22 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Publications (1)

Publication Number Publication Date
BRPI0516372A true BRPI0516372A (en) 2008-09-02

Family

ID=38475284

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516372-2A BRPI0516372A (en) 2005-12-22 2005-12-22 multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Country Status (6)

Country Link
EP (1) EP1963522A4 (en)
JP (1) JP2009521434A (en)
CN (1) CN101443454A (en)
BR (1) BRPI0516372A (en)
MX (1) MX2007007790A (en)
WO (1) WO2007102797A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327605B (en) * 2011-08-25 2013-01-30 成都康华生物制品有限公司 Preparation process of meningococcal polysaccharide vaccine
CN102809656B (en) * 2012-08-26 2014-09-03 云南沃森生物技术股份有限公司 Method for detecting content of each group of free polysaccharide in meningococcus polysaccharide conjugate vaccine finished product
ES2672045T3 (en) * 2014-07-25 2018-06-12 Biosynth S.R.L. Vaccines of glycoconjugate products comprising basic units of a molecular construction expressing multiple incorporated epitopes for the formulation of a broad-spectrum vaccine against infections due to enteropathogenic bacteria
CN104383532A (en) * 2014-12-02 2015-03-04 云南沃森生物技术股份有限公司 Bacterial polysaccharide protein conjugate vaccine using hepatitis B surface antigen as carrier protein and preparation method of bacterial polysaccharide protein conjugate vaccine
CA3033364A1 (en) 2016-09-02 2018-03-08 Sanofi Pasteur, Inc. Neisseria meningitidis vaccine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425946A (en) * 1992-08-31 1995-06-20 North American Vaccine, Inc. Vaccines against group C Neisseria meningitidis
EP0994723A1 (en) * 1997-06-24 2000-04-26 Chiron Corporation Methods of immunizing adults using anti-meningococcal vaccine compositions
CA2524853A1 (en) * 2003-05-07 2005-01-20 Aventis Pasteur, Inc. Method of enhanced immunogenicity to meningococcal vaccination

Also Published As

Publication number Publication date
JP2009521434A (en) 2009-06-04
WO2007102797A2 (en) 2007-09-13
MX2007007790A (en) 2009-06-05
WO2007102797A3 (en) 2009-04-16
EP1963522A2 (en) 2008-09-03
EP1963522A4 (en) 2010-05-12
CN101443454A (en) 2009-05-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 9A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2285 DE 21/10/2014.