BRPI0505141A - method for the determination of impurities in trodat-1 raw material - Google Patents

method for the determination of impurities in trodat-1 raw material

Info

Publication number
BRPI0505141A
BRPI0505141A BRPI0505141A BRPI0505141A BR PI0505141 A BRPI0505141 A BR PI0505141A BR PI0505141 A BRPI0505141 A BR PI0505141A BR PI0505141 A BRPI0505141 A BR PI0505141A
Authority
BR
Brazil
Prior art keywords
trodat
impurities
raw material
feedstock
liquid chromatography
Prior art date
Application number
Other languages
Portuguese (pt)
Inventor
Kung Tien Liu
Yi Chih Hsia
Chang Yung Su
Chiung Fang Huang
Ying Kai Fu
Original Assignee
Inst Nuclear Energy Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nuclear Energy Res filed Critical Inst Nuclear Energy Res
Priority to BRPI0505141 priority Critical patent/BRPI0505141B1/en
Publication of BRPI0505141A publication Critical patent/BRPI0505141A/en
Publication of BRPI0505141B1 publication Critical patent/BRPI0505141B1/en

Links

Abstract

Método para a determinação de impurezas em matéria-prima de TRODAT-1. O presente invento descreve uma tecnologia para ensaio de impurezas da matéria-prima de TRODAT-1 por cromatografia líquida de alta resolução em fase reserva (RP-HPLC). O método para o ensaio de impurezas da matéria-prima de TRODAT-1 do presente invento inclui usar cromatografia líquida de alta resolução (HPLC), e espectrometria de massa acoplada a cromatografia líquida (LC-MS/MS), coluna de HPLC, preparação de amostras, reagentes e eluentes, bem como realizar análise de íonos de precursores e de produtos por espectrometria de massa para a validação do método, cálculo de resolução cromatográfica e de impurezas da matéria-prima . O presente invento é o primeiro relato no mundo que provou a existência de oligómeros na matéria-prima de TRODAT-1, bem como é um método analítico através de procedimentos elaborados de validação para quantificar as impurezas (incluindo os oligómeros) em matéria-prima de TRODAT-1.Method for the determination of impurities in TRODAT-1 raw material. The present invention describes a technology for testing TRODAT-1 feedstock impurities by standby high performance liquid chromatography (RP-HPLC). The method for assaying TRODAT-1 raw material impurities of the present invention includes using high performance liquid chromatography (HPLC), and liquid chromatography-coupled mass spectrometry (LC-MS / MS), HPLC column, preparation samples, reagents and eluents, as well as perform precursor and product ion analysis by mass spectrometry for method validation, calculation of chromatographic resolution and impurities of the raw material. The present invention is the first report in the world to prove the existence of oligomers in TRODAT-1 feedstock, as well as an analytical method through elaborate validation procedures to quantify impurities (including oligomers) in feedstock. TRODAT-1.

BRPI0505141 2005-11-17 2005-11-17 Method for the determination of impurities in trodat-1. BRPI0505141B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BRPI0505141 BRPI0505141B1 (en) 2005-11-17 2005-11-17 Method for the determination of impurities in trodat-1.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0505141 BRPI0505141B1 (en) 2005-11-17 2005-11-17 Method for the determination of impurities in trodat-1.

Publications (2)

Publication Number Publication Date
BRPI0505141A true BRPI0505141A (en) 2007-08-07
BRPI0505141B1 BRPI0505141B1 (en) 2013-06-04

Family

ID=38331829

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0505141 BRPI0505141B1 (en) 2005-11-17 2005-11-17 Method for the determination of impurities in trodat-1.

Country Status (1)

Country Link
BR (1) BRPI0505141B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114689739A (en) * 2022-01-30 2022-07-01 江苏省原子医学研究所 99mSeparation method of Tc-TRODAT-1 diastereoisomer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114689739A (en) * 2022-01-30 2022-07-01 江苏省原子医学研究所 99mSeparation method of Tc-TRODAT-1 diastereoisomer
CN114689739B (en) * 2022-01-30 2023-10-03 江苏省原子医学研究所 99m Separation method of Tc-TRODAT-1 diastereoisomer

Also Published As

Publication number Publication date
BRPI0505141B1 (en) 2013-06-04

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/11/2005, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved