BRPI0415885A - piperidinyl- and piperazinylsulfonylmethylhydroxamic acids and their use as protease inhibitors - Google Patents
piperidinyl- and piperazinylsulfonylmethylhydroxamic acids and their use as protease inhibitorsInfo
- Publication number
- BRPI0415885A BRPI0415885A BRPI0415885-7A BRPI0415885A BRPI0415885A BR PI0415885 A BRPI0415885 A BR PI0415885A BR PI0415885 A BRPI0415885 A BR PI0415885A BR PI0415885 A BRPI0415885 A BR PI0415885A
- Authority
- BR
- Brazil
- Prior art keywords
- acids
- piperidinyl
- activity
- protease inhibitors
- hydroxamic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
"áCIDOS PIPERIDINIL- E PIPERAZINIL- SULFONILMETILIDROXáMICOS E SUA UTILIZAçãO COMO INIBIDORES DE PROTEASE". A presente invenção é dirigida, de um modo geral, a inibidores de proteinases (também conhecidas como 'proteases') e, mais particularmente, a ácidos piperidinil- e piperazinil-sulfonilmetilhidroxâmicos que, inter alia, inibem a atividade de metaloproteinases de matriz (também conhecidas como 'metaloproteases de matriz' ou 'MMP') e/ou a atividade de agrecanase. Esses ácidos hidroxâmicos correspondem geralmente em estrutura à fórmula (I); (em que A¬ 1¬, A¬ 2¬ Y, E¬ 1¬, E¬ 2¬, E¬ 3¬ e R¬ x¬ são como definidos nesta descrição) e inclui ainda sais desses compostos. A presente invenção é também dirigida a composições desses ácidos hidroxâmicos, intermediários para a síntese de tais ácidos hidroxâmicos, métodos para preparar esses ácidos hidroxâmicos e métodos para o tratamento de condições (particularmente condições patológicas) associadas com a atividade de MMP e/ou a atividade de agrecanase."PIPERIDINYL-PIPERAZINYL-SULPHONYLYTHYLROXYMATIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS". The present invention is generally directed to protease inhibitors (also known as proteases) and more particularly to piperidinyl and piperazinyl sulfonyl methylhydroxamic acids which, inter alia, inhibit the activity of matrix metalloproteinases (also known as proteases). known as 'matrix metalloproteases' or 'MMP') and / or agrecanase activity. Such hydroxamic acids generally correspond in structure to formula (I); (wherein A¬ 1¬, A¬ 2¬ Y, E¬ 1¬, E¬ 2¬, E¬ 3¬ and R¬ x¬ are as defined in this description) and further include salts of these compounds. The present invention is also directed to compositions of such hydroxamic acids, intermediates for the synthesis of such hydroxamic acids, methods for preparing such hydroxamic acids and methods for treating conditions (particularly pathological conditions) associated with MMP activity and / or activity. of agrecanase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/700,202 US20050209278A1 (en) | 2002-04-25 | 2003-11-03 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
PCT/US2004/036666 WO2005042521A2 (en) | 2003-11-03 | 2004-11-03 | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0415885A true BRPI0415885A (en) | 2007-01-02 |
Family
ID=34551155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0415885-7A BRPI0415885A (en) | 2003-11-03 | 2004-11-03 | piperidinyl- and piperazinylsulfonylmethylhydroxamic acids and their use as protease inhibitors |
Country Status (6)
Country | Link |
---|---|
US (1) | US20050209278A1 (en) |
EP (1) | EP1689743A2 (en) |
JP (1) | JP2007510732A (en) |
BR (1) | BRPI0415885A (en) |
CA (1) | CA2543715A1 (en) |
WO (1) | WO2005042521A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20070341A1 (en) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | PIRROL DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS |
CN101730692A (en) * | 2007-03-15 | 2010-06-09 | 先灵公司 | Pyridazinone derivatives useful as glucan synthase inhibitors |
JP5305462B2 (en) * | 2007-03-27 | 2013-10-02 | 塩野義製薬株式会社 | Method for producing N-phenyl-N'-phenylsulfonylpiperazine derivative |
EP2188272B1 (en) | 2007-08-06 | 2016-02-24 | reMynd NV | Phenyl- and benzylthiazolylpiperazine derivatives for the treatment of neurodegenerative diseases |
FR2948370B1 (en) | 2009-07-27 | 2013-04-05 | Sanofi Aventis | TETRAHYDROQUINOXALINE UREA DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
FR2948369B1 (en) | 2009-07-27 | 2013-04-12 | Sanofi Aventis | TETRAHYDROQUINOXALINE UREA DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
CN103096893B (en) | 2010-06-04 | 2016-05-04 | 阿尔巴尼分子研究公司 | Glycine transporter-1 inhibitor, Its Preparation Method And Use |
US9708299B2 (en) * | 2011-01-03 | 2017-07-18 | Genentech, Inc. | Hedgehog antagonists having zinc binding moieties |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
CA2110514A1 (en) * | 1991-07-05 | 1993-01-21 | Raymond Baker | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
EP0780386B1 (en) * | 1995-12-20 | 2002-10-02 | F. Hoffmann-La Roche Ag | Matrix metalloprotease inhibitors |
DK0939628T3 (en) * | 1996-07-22 | 2003-07-07 | Monsanto Co | Thiolsulfon-metalloprotease inhibitors |
ZA98376B (en) * | 1997-01-23 | 1998-07-23 | Hoffmann La Roche | Sulfamide-metalloprotease inhibitors |
US20010039287A1 (en) * | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
GB9725782D0 (en) * | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
CA2362230A1 (en) * | 1999-02-08 | 2000-08-10 | G.D. Searle & Co. | Sulfamato hydroxamic acid metalloprotease inhibitor |
US6800646B1 (en) * | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
US6300515B1 (en) * | 1999-04-15 | 2001-10-09 | Mitsubishi Chemical Corporation | Process for the isomerization of allylic compounds |
GB9912961D0 (en) * | 1999-06-03 | 1999-08-04 | Pfizer Ltd | Metalloprotease inhibitors |
US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
MXPA03010326A (en) * | 2001-05-11 | 2004-07-30 | Pharmacia Corp | Aromatic sulfone hydroxamates and their use as protease inhibitors. |
US20040024024A1 (en) * | 2001-05-11 | 2004-02-05 | Freskos John N. | Aromatic sulfone hydroxamates and their use as protease inhibitors |
US6683078B2 (en) * | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
JP2005537228A (en) * | 2002-04-25 | 2005-12-08 | ファルマシア・コーポレーション | Piperidinyl- and piperazinyl-sulfonylmethylhydroxamic acids and their use as protease inhibitors |
-
2003
- 2003-11-03 US US10/700,202 patent/US20050209278A1/en not_active Abandoned
-
2004
- 2004-11-03 EP EP04810297A patent/EP1689743A2/en not_active Withdrawn
- 2004-11-03 CA CA002543715A patent/CA2543715A1/en not_active Abandoned
- 2004-11-03 JP JP2006539634A patent/JP2007510732A/en not_active Withdrawn
- 2004-11-03 WO PCT/US2004/036666 patent/WO2005042521A2/en active Application Filing
- 2004-11-03 BR BRPI0415885-7A patent/BRPI0415885A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2005042521A2 (en) | 2005-05-12 |
CA2543715A1 (en) | 2005-05-12 |
JP2007510732A (en) | 2007-04-26 |
US20050209278A1 (en) | 2005-09-22 |
EP1689743A2 (en) | 2006-08-16 |
WO2005042521A3 (en) | 2005-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0309671A (en) | piperidinyl and piperazinyl sulfonylmethyl hydroxamic acids and their use as protease inhibitors | |
BR0008440A (en) | Hydroxamic acid sulfamate metalloprotease inhibitor | |
ATE233552T1 (en) | THIOL-SULFONES AS METALLOPROTEINASE INHIBITORS | |
BRPI0517035A (en) | new compounds | |
EA200101085A1 (en) | HYDROXAMIC ACIDS, DERIVATIVES OF AROMATIC SULPHONES, - METALLOPROTEASIS INHIBITORS | |
BR0317020A (en) | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | |
DE60329316D1 (en) | PHENYL ACARBOXAMIDE AS A BETA SEKRETASE INHIBITOR FOR THE TREATMENT OF ALZHEIMER | |
BR0115452A (en) | Compounds having fungicidal activity and processes for their manufacture and use | |
BRPI0615223A2 (en) | serine protease inhibitors | |
UY27558A1 (en) | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION WATERFALL | |
TNSN02008A1 (en) | NEW MMP INHIBITOR ISOPHTHALIC ACID DERIVATIVES AND COMPOSITIONS CONTAINING THEM | |
TNSN02012A1 (en) | NOVEL PYRIMIDINE DERIVATIVES OF MMP INHIBITORS, AND COMPOSITIONS CONTAINING THEM | |
EA200500472A1 (en) | ACETYL 2-HYDROXY-1,3-DIAMINO-ALKANES | |
DE60120881D1 (en) | SULPHONAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | |
BR0206501A (en) | Cruzipain and other cysteine protease inhibitors | |
EA200100804A1 (en) | SULPHOOROMATIC DERIVATIVES OF HYDROXAMIC ACID AS METHYPE PROTEASIS INHIBITORS | |
BRPI0408444A (en) | 1-n- (phenyl) -2-n- (phenyl) pyrazolidine-1,2-dicarboxamide derivatives as coagulation factor xa inhibitors for the treatment of thrombosis | |
ATE509920T1 (en) | SQUARE ACID DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | |
BRPI0513267A (en) | improved aprotinin variants | |
BRPI0415885A (en) | piperidinyl- and piperazinylsulfonylmethylhydroxamic acids and their use as protease inhibitors | |
DK1071704T3 (en) | New matrix metalloproteinase inhibitors and down regulators | |
BR0208499A (en) | 3-heterocyclylpropanohydroxamic acid as procollagen c-proteinase inhibitors | |
BRPI0511323A (en) | Substituted tetrahydroisoquinolines used in the form of mmp inhibitors, method for their production and use as dragees | |
BR9713207A (en) | Derivatives of 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepane useful as matrix metalloproteinase inhibitors | |
BR0315055A (en) | Pyrimidin-4,6-dicarboxylic acid diacids for selective collagenase inhibition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |