BRPI0415678A - pyrimidine compounds for treating inflammation - Google Patents
pyrimidine compounds for treating inflammationInfo
- Publication number
- BRPI0415678A BRPI0415678A BRPI0415678-1A BRPI0415678A BRPI0415678A BR PI0415678 A BRPI0415678 A BR PI0415678A BR PI0415678 A BRPI0415678 A BR PI0415678A BR PI0415678 A BRPI0415678 A BR PI0415678A
- Authority
- BR
- Brazil
- Prior art keywords
- pyrimidine compounds
- treating inflammation
- compounds
- pyrimidine
- inflammation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
"COMPOSTOS DE PIRIMIDINA PARA O TRATAMENTO DE INFLAMAçãO". São revelados compostos de Fórmula I: em que A, X, R¬ 2¬ e R¬ 4¬ são conforme aqui definidos."PYRIMIDINE COMPOUNDS FOR INFLAMMATION TREATMENT". Compounds of Formula I are disclosed: wherein A, X, R 2 and R 4 are as defined herein.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51377003P | 2003-10-23 | 2003-10-23 | |
PCT/IB2004/003314 WO2005040133A1 (en) | 2003-10-23 | 2004-10-11 | Pyrimidine compounds for the treatment of inflammation |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0415678A true BRPI0415678A (en) | 2006-12-19 |
Family
ID=34520134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0415678-1A BRPI0415678A (en) | 2003-10-23 | 2004-10-11 | pyrimidine compounds for treating inflammation |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1678146A1 (en) |
JP (1) | JP2007509126A (en) |
BR (1) | BRPI0415678A (en) |
CA (1) | CA2542514A1 (en) |
MX (1) | MXPA06004498A (en) |
WO (1) | WO2005040133A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
DE102005025225A1 (en) * | 2005-06-01 | 2006-12-07 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of 2- (2-amino-pyrimidin-4-yl) -1H-indole-5-carboxylic acid derivatives |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
GB0520657D0 (en) * | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
MX2009003793A (en) | 2006-10-09 | 2009-12-14 | Takeda Pharmaceutical | Kinase inhibitors. |
JP2011032169A (en) * | 2007-12-11 | 2011-02-17 | Genecare Research Institute Co Ltd | 4-aminopyrimidine derivative and medicinal composition containing the compound |
DE102007061756A1 (en) | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituted 4-aminopyrimidine-5-carboxylic acids and their use |
CN102458402B (en) | 2009-06-12 | 2013-10-02 | 百时美施贵宝公司 | Nicotinamide compounds useful as kinase modulators |
SG181504A1 (en) | 2009-12-23 | 2012-07-30 | Sanofi Sa | Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors |
US8685993B2 (en) | 2010-12-21 | 2014-04-01 | Novartis Ag | Bi-heteroaryl compounds as Vps34 inhibitors |
WO2017088755A1 (en) * | 2015-11-23 | 2017-06-01 | Suzhou Yunxuan Yiyao Keji Youxian Gongsi | Aminopyrimidine heterocyclic compound with adenosine receptor antagonistic activity |
JOP20190024A1 (en) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | Substituted pyrrolizine compounds and uses thereof |
CA3091142C (en) | 2018-02-26 | 2023-04-11 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD236310A1 (en) * | 1984-08-23 | 1986-06-04 | Univ Leipzig | PROCESS FOR PREPARING 2,6-DIARYL SUBSTITUTED 4-ARYLAMINO-PYRIMIDIN-5-CARBOXYLIC ACID ESTERS |
JP2001089452A (en) * | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | Pyrimidine derivative |
US6869956B2 (en) * | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
AU2002228922A1 (en) * | 2000-12-12 | 2002-06-24 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
CA2474578C (en) * | 2002-02-13 | 2009-08-25 | F. Hoffmann-La Roche Ag | Novel pyridin- and pyrimidin-derivatives |
GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
-
2004
- 2004-10-11 BR BRPI0415678-1A patent/BRPI0415678A/en not_active Application Discontinuation
- 2004-10-11 MX MXPA06004498A patent/MXPA06004498A/en unknown
- 2004-10-11 EP EP04769607A patent/EP1678146A1/en not_active Withdrawn
- 2004-10-11 WO PCT/IB2004/003314 patent/WO2005040133A1/en not_active Application Discontinuation
- 2004-10-11 JP JP2006536194A patent/JP2007509126A/en not_active Withdrawn
- 2004-10-11 CA CA002542514A patent/CA2542514A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2005040133A1 (en) | 2005-05-06 |
JP2007509126A (en) | 2007-04-12 |
EP1678146A1 (en) | 2006-07-12 |
MXPA06004498A (en) | 2006-06-20 |
CA2542514A1 (en) | 2005-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0209127A (en) | compounds, pharmaceutical compositions, methods for treating pain, methods for modulating a pharmacological response and uses of compounds | |
BR0209129A (en) | Compounds, pharmaceutical compositions, methods for treating pain, methods for modulating a pharmacological response and uses of compounds. | |
BR0309355A (en) | 2- (2,6-dichlorophenyl) diarylimidazoles | |
BR0316487A (en) | Whole method of treating transplant rejection | |
EA200700851A1 (en) | OBTAINING AND APPLICATION OF BIPHENYL-4-ILKARBONYLAMINO ACID DERIVATIVES FOR TREATMENT OF OBESITY | |
ATE408601T1 (en) | FREDERICAMYCIN DERIVATIVES | |
DK1519724T3 (en) | Fredericamycin derivatives as drugs for the treatment of tumors | |
TW200510325A (en) | 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof | |
DK1558579T3 (en) | N-alkyl-4-methylenamino-3-hydroxy-2-pyridones as antimicrobials | |
EA201000563A1 (en) | TRIAZOLPYRIDINE INHIBITORS 11-BETA-HYDROXYSTEROID - DEHYDROGENASE TYPE I | |
ECSP056210A (en) | PREPARATION AND USE OF RENTAL DERIVATIVES FOR THE TREATMENT OF OBESITY | |
GEP20053660B (en) | Novel Tyrosine Kinase Inhibitors | |
BR0309343A (en) | Compound, pharmaceutical composition, use of a compound, and method of treating or prophylaxis of human diseases or conditions. | |
EA200802213A1 (en) | METHODS OF TREATING BLOOD DISEASES | |
HK1079522A1 (en) | Thienyl compounds | |
PH12013500123A1 (en) | Hemiasterlin derivatives and uses thereof | |
ATE525067T1 (en) | AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULPHONES FOR THE TREATMENT OF PROLIFETING DISEASES | |
BRPI0410669A (en) | caspase inhibitors and their uses | |
BRPI0511138A (en) | pyrimidine derivatives for the treatment of abnormal cell development | |
BRPI0415678A (en) | pyrimidine compounds for treating inflammation | |
BRPI0416030A (en) | hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | |
BR0209128A (en) | Compounds, pharmaceutical compositions, methods for treating pain, methods for modulating a pharmacological response and uses of compounds | |
MXPA05013751A (en) | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof. | |
ATE549024T1 (en) | QUINAZOLINE POTASSIUM CHANNEL INHIBITORS | |
BR0208499A (en) | 3-heterocyclylpropanohydroxamic acid as procollagen c-proteinase inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |