BRPI0412247A - use of 3,7-diazabicyclo [3.3.1] nonane compounds for the treatment and / or prophylaxis of arrhythmic episodes in male human patients - Google Patents

use of 3,7-diazabicyclo [3.3.1] nonane compounds for the treatment and / or prophylaxis of arrhythmic episodes in male human patients

Info

Publication number
BRPI0412247A
BRPI0412247A BRPI0412247-0A BRPI0412247A BRPI0412247A BR PI0412247 A BRPI0412247 A BR PI0412247A BR PI0412247 A BRPI0412247 A BR PI0412247A BR PI0412247 A BRPI0412247 A BR PI0412247A
Authority
BR
Brazil
Prior art keywords
diazabicyclo
treatment
prophylaxis
compounds
patients
Prior art date
Application number
BRPI0412247-0A
Other languages
Portuguese (pt)
Inventor
Werner Cautreels
Claus Steinborn
Matthias Straub
Katrin Beckmann
Johannes Wilhelmus Cath Jansen
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of BRPI0412247A publication Critical patent/BRPI0412247A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"USO DE COMPOSTOS 3,7-DIAZABICICLO ¢3.3.1! NONANO PARA O TRATAMENTO E/OU PROFILAXIA DE EPISóDIOS ARRìTMICOS EM DOENTES HUMANOS DO SEXO MASCULINO". A presente invenção refere-se ao uso de compostos 3,7 diazabiciclo ¢3,3,1!nonano, de um modo preferido de compostos 9,9 alquileno-3,7-diazabiciclo¢3.3.1!-nonano e, de um modo muito preferido à uso de tedisamil, e os seus sais de adição ádica e/ou solvatos fisiologicamente aceitáveis, para o tratamento e/ou profilaxia de episódios anti-arrítmicos em doentes humanos do sexo masculino, de um modo preferido na conversão da fibrilação auricular (Afib) ou flutter auricular recentemente estabelecidas a ritmo sinusal normal (NSR) em doentes humanos do sexo masculino."USE OF 3,7-DIAZABICYCLE ¢ 3.3.1! NONANO COMPOUNDS FOR THE TREATMENT AND / OR PROPHILAXY OF ARRHYMIC EPISODES IN HUMAN MALE SEX PATIENTS". The present invention relates to the use of 3,7 diazabicyclo [3,3,1] nonane compounds, preferably 9.9 alkylene-3,7-diazabicyclo [3.3.1] nonane compounds, and preferably Most preferred is the use of tedisamil, and its physiologically acceptable acidic addition salts and / or solvates, for the treatment and / or prophylaxis of antiarrhythmic episodes in male human patients, preferably in the conversion of atrial fibrillation. (Afib) or newly established atrial flutter at normal sinus rhythm (NSR) in human male patients.

BRPI0412247-0A 2003-07-21 2004-07-19 use of 3,7-diazabicyclo [3.3.1] nonane compounds for the treatment and / or prophylaxis of arrhythmic episodes in male human patients BRPI0412247A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03102243 2003-07-21
PCT/EP2004/051532 WO2005011690A1 (en) 2003-07-21 2004-07-19 Use of 3,7-diazabicyclo`3, 3,1 !nonane compounds for the treatment and/or prophylaxis of anti-arrhythmic events in male human patients

Publications (1)

Publication Number Publication Date
BRPI0412247A true BRPI0412247A (en) 2006-09-19

Family

ID=34112472

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412247-0A BRPI0412247A (en) 2003-07-21 2004-07-19 use of 3,7-diazabicyclo [3.3.1] nonane compounds for the treatment and / or prophylaxis of arrhythmic episodes in male human patients

Country Status (8)

Country Link
EP (1) EP1648456A1 (en)
JP (1) JP2006528155A (en)
CN (1) CN1822833A (en)
AU (1) AU2004260624A1 (en)
BR (1) BRPI0412247A (en)
CA (1) CA2533492A1 (en)
MX (1) MXPA06000796A (en)
WO (1) WO2005011690A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012253653A1 (en) 2011-05-10 2013-05-02 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
NO3175985T3 (en) 2011-07-01 2018-04-28
UY34171A (en) 2011-07-01 2013-01-31 Gilead Sciences Inc FUSIONED HETEROCYCLIC COMPOUNDS AS IONIC CHANNEL MODULATORS
WO2014134419A1 (en) * 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3234697A1 (en) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover NEW DIAZABICYCLO (3,3,1) NONANA
PT88381B (en) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh PROCESS FOR THE PREPARATION OF NEW COMPOUNDS 3,7-DIAZABICYCLO (3,3,1) NONANO, AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
DE4139763A1 (en) * 1991-12-03 1993-06-09 Kali-Chemie Pharma Gmbh, 3000 Hannover, De CRYSTALLINE FUMAR ACID SALTS OF 9,9-ALKYLENE-3,7-DIAZABICYCLONONAN COMPOUNDS AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
TW200418468A (en) * 2002-11-18 2004-10-01 Solvay Pharm Gmbh Liquid pharmaceutical formulations containing 3,7-diazabicyclo[3,3,1]nonane compounds and method of treatments relating to anti-arrhytmic events

Also Published As

Publication number Publication date
AU2004260624A1 (en) 2005-02-10
EP1648456A1 (en) 2006-04-26
CN1822833A (en) 2006-08-23
JP2006528155A (en) 2006-12-14
WO2005011690A1 (en) 2005-02-10
CA2533492A1 (en) 2005-02-10
MXPA06000796A (en) 2006-04-07

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired