BRPI0409511A - compound, pharmaceutical composition, and compound use - Google Patents

compound, pharmaceutical composition, and compound use

Info

Publication number
BRPI0409511A
BRPI0409511A BRPI0409511-1A BRPI0409511A BRPI0409511A BR PI0409511 A BRPI0409511 A BR PI0409511A BR PI0409511 A BRPI0409511 A BR PI0409511A BR PI0409511 A BRPI0409511 A BR PI0409511A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
transhydroxycycloexyl
pyrrolo
phenyl
Prior art date
Application number
BRPI0409511-1A
Other languages
Portuguese (pt)
Inventor
Timo Heinrich
Axel Pahl
Bernd-Martin Luitjens
Emil Finner
Pieter C Verveer
Jan Zorgdrager
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of BRPI0409511A publication Critical patent/BRPI0409511A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, USO DO COMPOSTO". A presente invenção diz respeito ao novo composto de mesilato de hidrogênio de 4-(4-trans-hidroxicicloexil)amino-2-fenil-7H-pirrolo¢2,3d!pirimidina, as formas polimórficas <244> e <225> destes e um método para a produção dos ditos compostos."COMPOUND, PHARMACEUTICAL COMPOSITION, AND, USE OF THE COMPOUND". The present invention relates to the novel 4- (4-transhydroxycycloexyl) amino-2-phenyl-7H-pyrrolo [2,3d] pyrimidine hydrogen mesylate compound, the polymorphic forms <244> and <225> thereof and a method for the production of said compounds.

BRPI0409511-1A 2003-04-22 2004-04-21 compound, pharmaceutical composition, and compound use BRPI0409511A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03101093 2003-04-22
PCT/EP2004/050573 WO2004094428A1 (en) 2003-04-22 2004-04-21 4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7h-pyrrolo`2, 3d! pyrimidine hydrogen mesylate and its polymorphic forms

Publications (1)

Publication Number Publication Date
BRPI0409511A true BRPI0409511A (en) 2006-04-18

Family

ID=36143550

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409511-1A BRPI0409511A (en) 2003-04-22 2004-04-21 compound, pharmaceutical composition, and compound use

Country Status (26)

Country Link
US (1) US7381729B2 (en)
EP (1) EP1641797B1 (en)
JP (1) JP2006524214A (en)
KR (1) KR20060021296A (en)
CN (1) CN100360533C (en)
AR (1) AR043880A1 (en)
AT (1) ATE373002T1 (en)
AU (1) AU2004232495B2 (en)
BR (1) BRPI0409511A (en)
CA (1) CA2522810A1 (en)
DE (1) DE602004008919T2 (en)
DK (1) DK1641797T3 (en)
ES (1) ES2290696T3 (en)
HK (1) HK1089767A1 (en)
IL (1) IL171120A (en)
MX (1) MXPA05011348A (en)
NO (1) NO20055495L (en)
PL (1) PL1641797T3 (en)
PT (1) PT1641797E (en)
RU (1) RU2345994C2 (en)
SA (1) SA04250093B1 (en)
SI (1) SI1641797T1 (en)
TW (1) TWI324517B (en)
UA (1) UA81806C2 (en)
WO (1) WO2004094428A1 (en)
ZA (1) ZA200508519B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR043880A1 (en) 2003-04-22 2005-08-17 Solvay Pharm Gmbh ACID MESILATE 4- (4.TRANS-HYDROXICICLOHEXIL) AMINO-2-PHENYL-7H-PIRROLO (2,3-D) PYRIMIDINE AND ITS POLYMORPHAS FORMS
WO2007073855A1 (en) * 2005-12-23 2007-07-05 Bayer Healthcare Ag Use of adenosine a1 receptor agonists for the protection of renal cells against toxic effects caused by aminoglycosides during treatment of infectious diseases
TW200808819A (en) * 2006-06-19 2008-02-16 Solvay Pharm Gmbh Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty
TWI561520B (en) 2012-09-27 2016-12-11 Sunshine Lake Pharma Co Ltd Crystalline forms of dihydropyrimidine derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55646B1 (en) * 1982-08-19 1990-12-05 Warner Lambert Co 3-deazaguanine sulfonic acid salts
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
JP2815691B2 (en) * 1990-09-20 1998-10-27 麒麟麦酒株式会社 KRN2391 acid addition salt and use thereof
FR2708604B1 (en) * 1993-07-30 1995-10-20 Sanofi Elf Use of benzenesulfonyl-indole derivatives for the preparation of medicaments.
JPH08198876A (en) * 1995-01-30 1996-08-06 Yoshitomi Pharmaceut Ind Ltd A trans-n-(1h-pyrazolo(3,4-b)pyridine-4-yl)-4-guanidinomethyl cyclohexane carboxamide-1 methane sulfonic acid salt-1 hydrate
JPH08337584A (en) * 1995-04-10 1996-12-24 Dai Ichi Seiyaku Co Ltd Condensed six-membered cyclic amino compound, medicine containing the same and production of the same
FR2749846B1 (en) * 1996-06-17 1998-09-11 Pf Medicament METHANESULFONATE SALT OF ARYLPIPERAZINE DERIVED FROM TRYPTAMINE AND ITS SOLVATES FOR PHARMACEUTICAL USE
MA24500A1 (en) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd CARBOXYLIC ACID SALT DERIVATIVE FROM NAPHTHYRIDINE.
US6878716B1 (en) * 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
MXPA00011889A (en) * 1998-06-02 2003-04-25 Osi Pharm Inc PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE.
TWI223598B (en) * 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
DK1246623T3 (en) * 1999-12-02 2006-11-13 Osi Pharm Inc Compounds specific for adenosine A1, A2a, and A3 receptor and uses thereof
KR100496089B1 (en) * 2000-03-03 2005-06-17 화이자 인코포레이티드 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylate and polymorphs
AU2687702A (en) * 2000-10-17 2002-04-29 Merck & Co Inc Orally active salts with tyrosine kinase activity
US6673802B2 (en) * 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) * 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
AR043880A1 (en) 2003-04-22 2005-08-17 Solvay Pharm Gmbh ACID MESILATE 4- (4.TRANS-HYDROXICICLOHEXIL) AMINO-2-PHENYL-7H-PIRROLO (2,3-D) PYRIMIDINE AND ITS POLYMORPHAS FORMS

Also Published As

Publication number Publication date
RU2345994C2 (en) 2009-02-10
UA81806C2 (en) 2008-02-11
TW200505457A (en) 2005-02-16
PL1641797T3 (en) 2008-01-31
IL171120A (en) 2011-01-31
RU2005136215A (en) 2006-03-20
ATE373002T1 (en) 2007-09-15
TWI324517B (en) 2010-05-11
PT1641797E (en) 2007-12-21
DK1641797T3 (en) 2007-10-29
CN1777606A (en) 2006-05-24
SA04250093B1 (en) 2008-07-12
CA2522810A1 (en) 2004-11-04
HK1089767A1 (en) 2006-12-08
US20040248912A1 (en) 2004-12-09
US7381729B2 (en) 2008-06-03
DE602004008919D1 (en) 2007-10-25
CN100360533C (en) 2008-01-09
KR20060021296A (en) 2006-03-07
NO20055495D0 (en) 2005-11-21
WO2004094428A1 (en) 2004-11-04
EP1641797A1 (en) 2006-04-05
ES2290696T3 (en) 2008-02-16
NO20055495L (en) 2006-01-23
ZA200508519B (en) 2007-04-25
JP2006524214A (en) 2006-10-26
AU2004232495B2 (en) 2010-04-22
MXPA05011348A (en) 2005-11-28
AU2004232495A1 (en) 2004-11-04
EP1641797B1 (en) 2007-09-12
DE602004008919T2 (en) 2008-06-19
AR043880A1 (en) 2005-08-17
SI1641797T1 (en) 2007-12-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 487/04; A61P 9/00

Ipc: C07D 487/04 (2011.01), A61P 9/00 (2011.01)

B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2258 DE 15/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.