BRPI0408494A - combined tumor therapy comprising nemorubicin with radiation therapy - Google Patents

combined tumor therapy comprising nemorubicin with radiation therapy

Info

Publication number
BRPI0408494A
BRPI0408494A BRPI0408494-2A BRPI0408494A BRPI0408494A BR PI0408494 A BRPI0408494 A BR PI0408494A BR PI0408494 A BRPI0408494 A BR PI0408494A BR PI0408494 A BRPI0408494 A BR PI0408494A
Authority
BR
Brazil
Prior art keywords
therapy
nemorubicin
radiation therapy
combined tumor
radiation
Prior art date
Application number
BRPI0408494-2A
Other languages
Portuguese (pt)
Inventor
Maria Cristina Rosa Geroni
Maria Adele Pacciarini
Antonino Suarato
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of BRPI0408494A publication Critical patent/BRPI0408494A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

"TERAPIA COMBINADA CONTRA TUMORES COMPREENDENDO NEMORUBICINA COM TERAPIA DE RADIAçãO". A presente invenção refere-se a um derivado morfolinil antraciclina para uso como rádio-sensibilizador, para administração combinada com terapia de radiação, de modo que possa ser revelado um efeito sinérgico."COMBINED TUMOR THERAPY UNDERSTANDING NEMORUBICINE WITH RADIATION THERAPY". The present invention relates to a morpholinyl anthracycline derivative for use as a radiosensitizer for administration in combination with radiation therapy so that a synergistic effect may be revealed.

BRPI0408494-2A 2003-03-18 2004-03-03 combined tumor therapy comprising nemorubicin with radiation therapy BRPI0408494A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03075781 2003-03-18
PCT/EP2004/050246 WO2004082579A2 (en) 2003-03-18 2004-03-03 Nemorubicin as radiosensitizer in combination with radiation therapy against tumors

Publications (1)

Publication Number Publication Date
BRPI0408494A true BRPI0408494A (en) 2006-04-04

Family

ID=33016931

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408494-2A BRPI0408494A (en) 2003-03-18 2004-03-03 combined tumor therapy comprising nemorubicin with radiation therapy

Country Status (8)

Country Link
EP (1) EP1603575A2 (en)
AU (1) AU2004222526A1 (en)
BR (1) BRPI0408494A (en)
CA (1) CA2519289A1 (en)
MX (1) MXPA05009851A (en)
NO (1) NO20054349L (en)
RU (1) RU2005132175A (en)
WO (1) WO2004082579A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006292482A1 (en) * 2005-09-16 2007-03-29 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing cancer using pyridine carboxaldehyde pyridine thiosemicarbazone radiosensitizing agents
EP2152236B1 (en) 2007-05-11 2015-09-02 Nerviano Medical Sciences S.r.l. Pharmaceutical composition of an anthracycline
US8742076B2 (en) 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
US8900589B2 (en) 2008-07-15 2014-12-02 Genetech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
CA2818713C (en) 2010-12-02 2019-03-26 Nerviano Medical Sciences S.R.L. Process for the preparation of morpholinyl anthracycline derivatives
CN106714844B (en) 2014-09-12 2022-08-05 基因泰克公司 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
KR102562864B1 (en) * 2014-11-05 2023-08-04 네르비아노 메디칼 사이언시스 에스.알.엘. Functionalized morpholinyl anthracycline derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB2296495B (en) * 1994-12-23 1998-04-15 Erba Carlo Spa Anthracycline derivatives
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
MXPA04009542A (en) * 2002-04-02 2005-01-25 Pharmacia Italia Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy.

Also Published As

Publication number Publication date
CA2519289A1 (en) 2004-09-30
WO2004082579A3 (en) 2004-11-11
NO20054349L (en) 2005-10-11
MXPA05009851A (en) 2005-12-06
WO2004082579A2 (en) 2004-09-30
RU2005132175A (en) 2006-01-27
AU2004222526A1 (en) 2004-09-30
EP1603575A2 (en) 2005-12-14

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]