BRPI0117343B8 - fluid composition for use as a controlled release implant, process for forming the same, use, kit and solid implant - Google Patents

fluid composition for use as a controlled release implant, process for forming the same, use, kit and solid implant

Info

Publication number
BRPI0117343B8
BRPI0117343B8 BRPI0117343A BRPI0117343B8 BR PI0117343 B8 BRPI0117343 B8 BR PI0117343B8 BR PI0117343 A BRPI0117343 A BR PI0117343A BR PI0117343 B8 BRPI0117343 B8 BR PI0117343B8
Authority
BR
Brazil
Prior art keywords
implant
fluid composition
solid
directed
present
Prior art date
Application number
Other languages
Portuguese (pt)
Inventor
L Chandrashekar Bhagya
Ravivarapu Harish
S Garrett John
L Dunn Richard
Original Assignee
Aspen Acquisition Ii Corp
Atrix Laboratories Inc
Qlt Usa Inc
Tolmar Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/711,758 external-priority patent/US6565874B1/en
Application filed by Aspen Acquisition Ii Corp, Atrix Laboratories Inc, Qlt Usa Inc, Tolmar Therapeutics Inc filed Critical Aspen Acquisition Ii Corp
Publication of BRPI0117343B1 publication Critical patent/BRPI0117343B1/en
Publication of BRPI0117343B8 publication Critical patent/BRPI0117343B8/en

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Abstract

composição fluida para uso como um implante de liberação controlada, processo para formação da mesma, uso, kit e implante sólido. a presente invenção está direcionada a uma composição fluida que é adequada para uso como um implante de liberação controlada. a composição fluida inclui um poliéster termoplástico biodegradável que seja pelo menos substancialmente insolúvel em meio aquoso ou fluido corpóreo e que seja um copolímero de lactato e glicolato tendo um grupo de proteção carboxi. a composição fluida também inclui um solvente aprótico polar biocompatível. o solvente aprótico polar biocompatível é miscível ou dispersível em meio aquoso ou fluido corpóreo. a composição fluida também inclui acetato de leuprolida. a presente invenção está também direcionada a um processo para formar a composição fluida. a presente invenção está também direcionada a um implante biodegradável formado in situ, em um paciente. o implante biodegradável é formado injetando-se uma composição fluida no corpo do paciente e permitindo o solvente aprótico polar biocompatível dissipar para produzir um implante biodegradável sólido. a presente invenção também está direcionada a um processo de formação de um implante biodegradável in situ, em um paciente vivo. o método inclui injetar uma composição fluida no corpo de um paciente e permitir que o solvente aprótico polar biocompatível dissipe para produzir um implante biodegradável sólido. a presente invenção está direcionada ao uso da composição na preparação de um medicamento para o tratamento do câncer em um paciente. a presente invenção está também direcionada a um kit. o kit inclui um primeiro recipiente e um segundo recipiente. o primeiro recipiente inclui uma composição que inclui um solvente aprótico polar biocompatível e um poliéster termoplástico biodegradável. o segundo recipiente inclui acetato de leuprolida. a presente invenção está também direcionada a um implante sólido. o implante sólido inclui um poliéster termoplástico biocompatível e acetato de leuprolida. o implante sólido tem uma matriz microporosa gelatinosa ou sólida, onde a matriz é um núcleo cercado por uma pele. o implante sólido pode adicionalmente incluir um solvente orgânico biocompatível.fluid composition for use as a controlled release implant, process for forming the same, use, kit and solid implant. The present invention is directed to a fluid composition that is suitable for use as a controlled release implant. the fluid composition includes a biodegradable thermoplastic polyester which is at least substantially insoluble in aqueous media or body fluid and which is a copolymer of lactate and glycolate having a carboxy protecting group. the fluid composition also includes a biocompatible polar aprotic solvent. the biocompatible polar aprotic solvent is miscible or dispersible in aqueous media or body fluid. the fluid composition also includes leuprolide acetate. the present invention is also directed to a process for forming the fluid composition. the present invention is also directed to a biodegradable implant formed in situ, in a patient. the biodegradable implant is formed by injecting a fluid composition into the patient's body and allowing the biocompatible polar aprotic solvent to dissipate to produce a solid biodegradable implant. the present invention is also directed to a process of forming a biodegradable implant in situ, in a living patient. the method includes injecting a fluid composition into a patient's body and allowing the biocompatible polar aprotic solvent to dissipate to produce a solid biodegradable implant. the present invention is directed to the use of the composition in the preparation of a medicament for the treatment of cancer in a patient. the present invention is also directed to a kit. the kit includes a first container and a second container. the first container includes a composition that includes a biocompatible polar aprotic solvent and a biodegradable thermoplastic polyester. the second container includes leuprolide acetate. the present invention is also directed to a solid implant. the solid implant includes a biocompatible thermoplastic polyester and leuprolide acetate. the solid implant has a gelatinous or solid microporous matrix, where the matrix is a core surrounded by skin. the solid implant may additionally include a biocompatible organic solvent.

BRPI0117343 2000-09-21 2001-09-21 fluid composition for use as a controlled release implant, process for forming the same, use, kit and solid implant BRPI0117343B8 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66617400A 2000-09-21 2000-09-21
US09/711,758 US6565874B1 (en) 1998-10-28 2000-11-13 Polymeric delivery formulations of leuprolide with improved efficacy
PCT/US2001/029612 WO2002030393A2 (en) 2000-09-21 2001-09-21 Polymeric delivery formulations of leuprolide with improved efficacy
BRPI0114069 2001-09-21

Publications (2)

Publication Number Publication Date
BRPI0117343B1 BRPI0117343B1 (en) 2019-12-03
BRPI0117343B8 true BRPI0117343B8 (en) 2021-05-25

Family

ID=68654960

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0117343 BRPI0117343B8 (en) 2000-09-21 2001-09-21 fluid composition for use as a controlled release implant, process for forming the same, use, kit and solid implant

Country Status (1)

Country Link
BR (1) BRPI0117343B8 (en)

Also Published As

Publication number Publication date
BRPI0117343B1 (en) 2019-12-03

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Legal Events

Date Code Title Description
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/12/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/12/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/09/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 21/09/2021