BR9915420A - Compound, pharmaceutical composition, methods of treating a disorder mediated by TNF and p38 kinase, inflammation and arthritis and the process of preparing pyrazoles - Google Patents
Compound, pharmaceutical composition, methods of treating a disorder mediated by TNF and p38 kinase, inflammation and arthritis and the process of preparing pyrazolesInfo
- Publication number
- BR9915420A BR9915420A BR9915420-0A BR9915420A BR9915420A BR 9915420 A BR9915420 A BR 9915420A BR 9915420 A BR9915420 A BR 9915420A BR 9915420 A BR9915420 A BR 9915420A
- Authority
- BR
- Brazil
- Prior art keywords
- kinase
- tnf
- arthritis
- inflammation
- treating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODOS DE TRATAR UM DISTúRBIO MEDIADO POR TNF E POR P38 CINASE, INFLAMAçãO E ARTRITE E PROCESSO DE PREPARAR PIRAZóIS". Uma classe de derivados de pirazóis é descrita para o uso no tratamento de distúrbios mediados pela p38 cinase. Os compostos de interesse particular são definidos pela Fórmula (1A), em que R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são como descritos no relatório descritivo."COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS OF TREATING A DISORDER MEDIATED BY TNF AND P38 KINASE, INFLAMMATION AND ARTHRITIS AND PROCESS OF PREPARING PIRAZÓIS". A class of pyrazole derivatives is described for use in the treatment of disorders mediated by p38 kinase. Compounds of particular interest are defined by Formula (1A), wherein R ^ 1 ^, R ^ 2 ^, R ^ 3 ^ and R ^ 4 ^ are as described in the specification.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/196,623 US6514977B1 (en) | 1997-05-22 | 1998-11-20 | Substituted pyrazoles as p38 kinase inhibitors |
PCT/US1999/026007 WO2000031063A1 (en) | 1998-11-20 | 1999-11-17 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915420A true BR9915420A (en) | 2002-01-22 |
Family
ID=22726159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915420-0A BR9915420A (en) | 1998-11-20 | 1999-11-17 | Compound, pharmaceutical composition, methods of treating a disorder mediated by TNF and p38 kinase, inflammation and arthritis and the process of preparing pyrazoles |
Country Status (35)
Country | Link |
---|---|
US (5) | US6514977B1 (en) |
EP (2) | EP1500657B1 (en) |
JP (1) | JP2002530397A (en) |
KR (1) | KR20030002291A (en) |
CN (1) | CN1342157A (en) |
AP (1) | AP2001002172A0 (en) |
AR (1) | AR035836A1 (en) |
AT (2) | ATE278685T1 (en) |
AU (1) | AU774262B2 (en) |
BG (1) | BG105620A (en) |
BR (1) | BR9915420A (en) |
CA (1) | CA2351725A1 (en) |
CZ (1) | CZ20011714A3 (en) |
DE (2) | DE69937163T2 (en) |
DK (2) | DK1500657T3 (en) |
EA (1) | EA005205B1 (en) |
EE (1) | EE200100268A (en) |
ES (2) | ES2229809T3 (en) |
GE (1) | GEP20053421B (en) |
HK (1) | HK1040705B (en) |
HR (1) | HRP20010363A2 (en) |
HU (1) | HUP0200130A2 (en) |
ID (1) | ID29993A (en) |
IL (1) | IL143120A0 (en) |
IS (1) | IS5938A (en) |
NO (1) | NO20012456L (en) |
NZ (1) | NZ512344A (en) |
OA (1) | OA11914A (en) |
PL (1) | PL353853A1 (en) |
PT (2) | PT1500657E (en) |
SK (1) | SK6862001A3 (en) |
TR (1) | TR200102001T2 (en) |
WO (1) | WO2000031063A1 (en) |
YU (1) | YU35601A (en) |
ZA (1) | ZA200103882B (en) |
Families Citing this family (158)
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US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
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- 1999-11-17 EP EP19990965756 patent/EP1144403B1/en not_active Expired - Lifetime
- 1999-11-19 AR ARP990105913A patent/AR035836A1/en unknown
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2000
- 2000-02-24 US US09/513,351 patent/US6525059B1/en not_active Expired - Fee Related
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2001
- 2001-05-09 IS IS5938A patent/IS5938A/en unknown
- 2001-05-14 ZA ZA200103882A patent/ZA200103882B/en unknown
- 2001-05-17 HR HR20010363A patent/HRP20010363A2/en not_active Application Discontinuation
- 2001-05-18 NO NO20012456A patent/NO20012456L/en not_active Application Discontinuation
- 2001-05-18 YU YU35601A patent/YU35601A/en unknown
- 2001-06-19 BG BG105620A patent/BG105620A/en unknown
- 2001-07-31 US US09/918,481 patent/US6423713B1/en not_active Expired - Fee Related
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2002
- 2002-03-22 HK HK02102213.5A patent/HK1040705B/en not_active IP Right Cessation
- 2002-04-02 US US10/114,297 patent/US6617324B1/en not_active Expired - Fee Related
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2003
- 2003-02-25 US US10/374,781 patent/US7153959B2/en not_active Expired - Fee Related
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