BR9914811A - Process for the preparation of quercetin and isoquercetin derivatives - Google Patents

Process for the preparation of quercetin and isoquercetin derivatives

Info

Publication number
BR9914811A
BR9914811A BR9914811-0A BR9914811A BR9914811A BR 9914811 A BR9914811 A BR 9914811A BR 9914811 A BR9914811 A BR 9914811A BR 9914811 A BR9914811 A BR 9914811A
Authority
BR
Brazil
Prior art keywords
preparation
quercetin
derivatives
isoquercetin
isoquercetin derivatives
Prior art date
Application number
BR9914811-0A
Other languages
Portuguese (pt)
Inventor
Herwig Buchholz
Ralf Rosskopf
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19850282A external-priority patent/DE19850282A1/en
Priority claimed from DE19850570A external-priority patent/DE19850570A1/en
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9914811A publication Critical patent/BR9914811A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE QUERCETINA E ISOQUERCETINA"<D>. é apresentado um método para a produção de compostos de fórmula (I), por meio do qual m, n, p e R. têm os significados dados na reivindicação 1. Ditos compostos podem ser usados de uma maneira vantajosa como suplementos de alimento. Eles são particularmente adequados para uso em formulações cosméticas como filtros de UV por exemplo.Invention Patent: <B> "PROCESS FOR THE PREPARATION OF QUERCETINE AND ISOQUERCETINE DERIVATIVES" <D>. a method for producing compounds of formula (I) is presented, whereby m, n, p and R. have the meanings given in claim 1. Said compounds can be used advantageously as food supplements. They are particularly suitable for use in cosmetic formulations such as UV filters for example.

BR9914811-0A 1998-10-30 1999-10-13 Process for the preparation of quercetin and isoquercetin derivatives BR9914811A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19850282A DE19850282A1 (en) 1998-10-30 1998-10-30 Preparation of new or known tris-hydroxyalkyl quercetin and isoquercetin derivatives by enzymatic cleavage of rutin derivatives, used e.g. as nutritional supplements, cosmetic UV filters or cardiovascular drugs
DE19850570A DE19850570A1 (en) 1998-11-02 1998-11-02 Production of new or known tri-O-hydroxyalkyl quercetin or isoquercetin derivatives, e.g. useful as food supplements, comprises enzymatic hydrolysis of tri-O-hydroxyalkyl rutin derivatives in an aqueous medium
PCT/EP1999/007685 WO2000026399A2 (en) 1998-10-30 1999-10-13 Method for the production of quercetin and isoquercetin derivatives

Publications (1)

Publication Number Publication Date
BR9914811A true BR9914811A (en) 2001-07-03

Family

ID=26049877

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914811-0A BR9914811A (en) 1998-10-30 1999-10-13 Process for the preparation of quercetin and isoquercetin derivatives

Country Status (8)

Country Link
EP (1) EP1124980A2 (en)
JP (1) JP2002528132A (en)
KR (1) KR20010080347A (en)
CN (1) CN1325452A (en)
AU (1) AU1036600A (en)
BR (1) BR9914811A (en)
CA (1) CA2348728A1 (en)
WO (1) WO2000026399A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19923715A1 (en) * 1999-05-22 2000-11-23 Beiersdorf Ag Cosmetic or dermatological sunscreen preparations containing flavone derivatives and / or flavanone derivatives, in particular flavonoids and s-triazine, and the use of UV filter substances having the structural motif of s-triazine for stabilizing flavone derivatives and / or flavanone derivatives, in particular flavonoids
DE19923712A1 (en) * 1999-05-22 2000-11-23 Beiersdorf Ag Active substance combination of sulfonated UV filter substances and flavone derivatives and / or flavanone derivatives, in particular flavonoids, and cosmetic preparations containing such active substance combinations
DE19923713A1 (en) * 1999-05-22 2000-11-23 Beiersdorf Ag Cosmetic or dermatological sunscreen preparations containing flavone derivatives and / or flavanone derivatives, in particular flavonoids and benzotriazole, and the use of UV filter substances having the structural motif of benzotriazole for stabilizing flavone derivatives and / or flavanone derivatives, in particular flavonoids
DE19927425A1 (en) * 1999-06-16 2000-12-21 Merck Patent Gmbh Obtaining isoquercetin from bioflavanoid pastes
EP1127572A3 (en) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Use of flavones for treating cycloxygenase-2 mediated diseases
DE10232595A1 (en) * 2002-07-18 2004-02-05 Merck Patent Gmbh Light stabilizers
DE102005015447A1 (en) * 2005-04-05 2006-10-12 Merck Patent Gmbh Process for the cleavage of rutinosides
CN101985439B (en) * 2010-11-18 2012-05-09 桂林市三棱生物制品有限公司 Process for separating and extracting 98% quercetin from aboveground part of pubescent holly root
JP2016013075A (en) * 2014-07-01 2016-01-28 イビデン株式会社 Quercetin-containing extract
CN105412074A (en) * 2015-12-24 2016-03-23 厦门大学 Application of quercetin in preparation of medicine for preventing and treating diseases related to ApoE protein level
US10639294B2 (en) 2018-10-02 2020-05-05 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide metabolite
US11304968B2 (en) 2018-11-16 2022-04-19 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5072M (en) * 1965-10-25 1967-05-16
US4603046A (en) * 1985-08-23 1986-07-29 Charles Of The Ritz Group Ltd. Improved sunscreen or sunblock composition
JPH01308476A (en) * 1988-06-06 1989-12-13 Showa Denko Kk Ultraviolet ray absorber
JPH03255013A (en) * 1990-03-01 1991-11-13 San Ei Chem Ind Ltd Cosmetic
JP3477628B2 (en) * 1995-06-19 2003-12-10 アサヒビール株式会社 Polyphenol preparation obtained from hop bract and its manufacturing method

Also Published As

Publication number Publication date
KR20010080347A (en) 2001-08-22
WO2000026399A3 (en) 2000-08-10
AU1036600A (en) 2000-05-22
CN1325452A (en) 2001-12-05
EP1124980A2 (en) 2001-08-22
WO2000026399A2 (en) 2000-05-11
CA2348728A1 (en) 2000-05-11
JP2002528132A (en) 2002-09-03

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.

B15K Others concerning applications: alteration of classification

Ipc: C12P 19/60 (2006.01), A23L 33/10 (2016.0