BR9913148A - Oral liquid mucoadhesive compositions - Google Patents

Oral liquid mucoadhesive compositions

Info

Publication number
BR9913148A
BR9913148A BR9913148-0A BR9913148A BR9913148A BR 9913148 A BR9913148 A BR 9913148A BR 9913148 A BR9913148 A BR 9913148A BR 9913148 A BR9913148 A BR 9913148A
Authority
BR
Brazil
Prior art keywords
composition
oral
safe
mixtures
effective amount
Prior art date
Application number
BR9913148-0A
Other languages
Portuguese (pt)
Inventor
Douglas Joseph Dobrozsi
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9913148A publication Critical patent/BR9913148A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Developing Agents For Electrophotography (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçõES MUCOADESIVAS LìQUIDAS ORAIS"<D>. A presente invenção refere-se a uma composição farmacêutica mucorretentiva per oral, oral, ou intranasal, líquida aquosa compreendendo a partir de cerca de 2 % a cerca de 50 %, em peso da composição, de partículas coloidais de sílica, dióxido de titânio, argila, e misturas dos mesmos e uma quantidade segura e eficaz de um ativo farmacêutico selecionado entre o grupo consistindo em analgésicos, descongestionantes, expectorantes, antitussígenos, anti-histamínicos, agentes sensórios, agentes gastrintestinais, e misturas dos mesmos; em que a composição tem uma proporção de volume de sedimentação de mais de cerca de 0,90 e em que a proporção da viscosidade visada da composição é de no mínimo cerca de 1,2. A presente invenção refere-se adicionalmente a um método de revestir o canal alimentar ou mucosa nasal, em particular a um método para prevenir ou tratar sintomas de infecções do trato respiratório superior ou irritação ou lesão do tecido do trato respiratório superior, por meio da administração de uma quantidade segura e eficaz da composição acima.Invention Patent: <B> "ORAL NET MUCOADS COMPOSITIONS" <D>. The present invention relates to a peroral, oral, or intranasal, mucoretentative pharmaceutical composition, aqueous liquid comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; where the composition has a sedimentation volume ratio of more than about 0.90 and where the composition's target viscosity ratio is at least about 1.2. The present invention further relates to a method of coating the alimentary canal or nasal mucosa, in particular a method for preventing or treating symptoms of upper respiratory tract infections or irritation or injury of upper respiratory tract tissue, by administering of a safe and effective amount of the above composition.

BR9913148-0A 1998-08-24 1999-08-24 Oral liquid mucoadhesive compositions BR9913148A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9764698P 1998-08-24 1998-08-24
PCT/US1999/019201 WO2000010528A1 (en) 1998-08-24 1999-08-24 Oral liquid mucoadhesive compositions

Publications (1)

Publication Number Publication Date
BR9913148A true BR9913148A (en) 2001-09-25

Family

ID=22264456

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913148-0A BR9913148A (en) 1998-08-24 1999-08-24 Oral liquid mucoadhesive compositions

Country Status (18)

Country Link
US (2) US20020009478A1 (en)
EP (1) EP1107732B1 (en)
JP (1) JP2002523353A (en)
KR (1) KR20010074834A (en)
CN (1) CN1313754A (en)
AT (1) ATE227978T1 (en)
AU (1) AU753251B2 (en)
BR (1) BR9913148A (en)
CA (1) CA2338480C (en)
CO (1) CO5140074A1 (en)
DE (1) DE69904057T2 (en)
DK (1) DK1107732T3 (en)
ES (1) ES2185395T3 (en)
HU (1) HUP0103217A2 (en)
NO (1) NO20010830D0 (en)
PE (1) PE20000863A1 (en)
TR (1) TR200100569T2 (en)
WO (1) WO2000010528A1 (en)

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Also Published As

Publication number Publication date
JP2002523353A (en) 2002-07-30
NO20010830L (en) 2001-02-19
DE69904057T2 (en) 2003-08-21
ATE227978T1 (en) 2002-12-15
TR200100569T2 (en) 2001-07-23
ES2185395T3 (en) 2003-04-16
EP1107732B1 (en) 2002-11-20
HUP0103217A2 (en) 2001-12-28
KR20010074834A (en) 2001-08-09
DK1107732T3 (en) 2003-03-17
CA2338480A1 (en) 2000-03-02
US20020076421A1 (en) 2002-06-20
AU753251B2 (en) 2002-10-10
US20020009478A1 (en) 2002-01-24
EP1107732A1 (en) 2001-06-20
DE69904057D1 (en) 2003-01-02
AU5580899A (en) 2000-03-14
NO20010830D0 (en) 2001-02-19
CA2338480C (en) 2004-10-05
WO2000010528A1 (en) 2000-03-02
PE20000863A1 (en) 2000-09-12
CN1313754A (en) 2001-09-19
CO5140074A1 (en) 2002-03-22
US6638521B2 (en) 2003-10-28

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4 A 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.