BR9912296A - Co-administration of acat and mmp inhibitors for the treatment of atherosclerotic lesions - Google Patents

Co-administration of acat and mmp inhibitors for the treatment of atherosclerotic lesions

Info

Publication number
BR9912296A
BR9912296A BR9912296-0A BR9912296A BR9912296A BR 9912296 A BR9912296 A BR 9912296A BR 9912296 A BR9912296 A BR 9912296A BR 9912296 A BR9912296 A BR 9912296A
Authority
BR
Brazil
Prior art keywords
acat
administration
mmp inhibitors
treatment
atherosclerotic lesions
Prior art date
Application number
BR9912296-0A
Other languages
Portuguese (pt)
Inventor
Tromas Michael Andrew Bocan
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9912296A publication Critical patent/BR9912296A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Patente de Invenção: <B>"CO-ADMINISTRAçãO DE INIBIDORES ACAT E MMP PARA O TRATAMENTO DE LESõES ATEROSCLERóTICAS"<D>. Esta invenção refere-se à co-administração de inibidores ACAT e MMP para a redução tanto do componente do macrófago como das células do músculo liso de lesões ateroscleróticas, assim inutilizando a expansão de lesões existents e o desenvolvimento de novas lesões e para a prevenção de ruptura de placas e a promoção da regressão de lesão em um animal.Invention Patent: <B> "CO-ADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF AEROSCLEROTIC INJURIES" <D>. This invention relates to the co-administration of ACAT and MMP inhibitors for the reduction of both the macrophage component and smooth muscle cells of atherosclerotic lesions, thus disabling the expansion of existing lesions and the development of new lesions and for the prevention of plaque rupture and promoting regression of injury in an animal.

BR9912296-0A 1998-07-21 1999-06-18 Co-administration of acat and mmp inhibitors for the treatment of atherosclerotic lesions BR9912296A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9363998P 1998-07-21 1998-07-21
PCT/US1999/013948 WO2000004892A2 (en) 1998-07-21 1999-06-18 Coadministration of acat and mmp inhibitors for the treatment of atherosclerotic lesions

Publications (1)

Publication Number Publication Date
BR9912296A true BR9912296A (en) 2001-04-17

Family

ID=22239992

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912296-0A BR9912296A (en) 1998-07-21 1999-06-18 Co-administration of acat and mmp inhibitors for the treatment of atherosclerotic lesions

Country Status (25)

Country Link
EP (1) EP1098662A2 (en)
JP (1) JP2002521328A (en)
KR (1) KR20010083134A (en)
CN (1) CN1310629A (en)
AP (1) AP2001002035A0 (en)
AU (1) AU4701799A (en)
BG (1) BG105162A (en)
BR (1) BR9912296A (en)
CA (1) CA2335062A1 (en)
CZ (1) CZ2001126A3 (en)
EA (1) EA200100153A1 (en)
EE (1) EE200100046A (en)
HR (1) HRP20010055A2 (en)
HU (1) HUP0102880A3 (en)
ID (1) ID30030A (en)
IL (1) IL140982A0 (en)
IS (1) IS5809A (en)
NO (1) NO20010291D0 (en)
OA (1) OA11584A (en)
PL (1) PL346011A1 (en)
SK (1) SK502001A3 (en)
TR (1) TR200100205T2 (en)
WO (1) WO2000004892A2 (en)
YU (1) YU3501A (en)
ZA (1) ZA200100294B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020050257A (en) * 1999-11-05 2002-06-26 로즈 암스트롱, 크리스틴 에이. 트러트웨인 Prevention of Plaque Rupture by ACAT Inhibitors
DOP2000000107A (en) 1999-12-01 2002-09-16 Agouron Pharmaceutical Inc COMPOUNDS, COMPOSITIONS AND METHODS TO STIMULATE THE GROWTH AND LENGTH OF NEURONS
AU2268401A (en) * 1999-12-17 2001-06-25 Versicor Inc Novel succinate compounds, compositions and methods of use and preparation
EP1314423A4 (en) * 2000-09-01 2004-05-19 Sankyo Co Medicinal compositions
GB0100761D0 (en) 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
JP4606027B2 (en) * 2002-04-03 2011-01-05 トポターゲット ユーケー リミテッド Carbamate compounds having piperazine bonds as HDAC inhibitors
JP4617449B2 (en) * 2002-07-11 2011-01-26 ヴィキュロン ファーマシューティカルズ インコーポレイテッド N-hydroxyamide derivative having antibacterial activity
WO2011092284A1 (en) * 2010-01-29 2011-08-04 Euroscreen S.A. Novel amino acid derivatives and their use as gpr43 receptor modulators
CN104211695B (en) * 2013-06-04 2017-04-12 中国医学科学院医药生物技术研究所 Use of group of carbamyl phenylsulfonyl compounds
US20180000817A1 (en) * 2015-01-15 2018-01-04 Biocant - Associação De Transferência De Tecnologia Treatment of hutchinson-gilford progeria syndrome and diseases related to vascular ageing
CN106831697B (en) * 2017-03-15 2019-11-05 深圳市康道生物有限公司 The effective extract component of river hazel and its application in prevention and treatment atherosclerosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
US5491172A (en) * 1993-05-14 1996-02-13 Warner-Lambert Company N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
CN1192140A (en) * 1995-08-04 1998-09-02 沃尼尔·朗伯公司 Use of sulfamic acid derivatives, acyl sulfonamides or sulfonyl carbamates for the manufacture of a medicament for lowering lipoprotein levels
KR20000011095A (en) * 1996-05-17 2000-02-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 Nonphenyl sulfoneamide as inhibitor of matrix metalloproteinase
WO1998009934A1 (en) * 1996-09-04 1998-03-12 Warner-Lambert Company Matrix metalloproteinase inhibitors and their therapeutic uses

Also Published As

Publication number Publication date
ID30030A (en) 2001-11-01
YU3501A (en) 2005-06-10
WO2000004892A3 (en) 2000-05-18
HRP20010055A2 (en) 2002-04-30
HUP0102880A3 (en) 2002-11-28
ZA200100294B (en) 2002-01-10
CZ2001126A3 (en) 2002-01-16
EA200100153A1 (en) 2001-08-27
CN1310629A (en) 2001-08-29
NO20010291L (en) 2001-01-18
AU4701799A (en) 2000-02-14
IS5809A (en) 2001-01-12
WO2000004892A2 (en) 2000-02-03
IL140982A0 (en) 2002-02-10
KR20010083134A (en) 2001-08-31
EE200100046A (en) 2002-06-17
JP2002521328A (en) 2002-07-16
CA2335062A1 (en) 2000-02-03
PL346011A1 (en) 2002-01-14
SK502001A3 (en) 2002-06-04
TR200100205T2 (en) 2001-05-21
OA11584A (en) 2004-07-20
AP2001002035A0 (en) 2001-03-31
NO20010291D0 (en) 2001-01-18
HUP0102880A2 (en) 2002-06-29
BG105162A (en) 2001-12-29
EP1098662A2 (en) 2001-05-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.