BR9814506A - Oligopetidians - Google Patents

Oligopetidians

Info

Publication number
BR9814506A
BR9814506A BR9814506-1A BR9814506A BR9814506A BR 9814506 A BR9814506 A BR 9814506A BR 9814506 A BR9814506 A BR 9814506A BR 9814506 A BR9814506 A BR 9814506A
Authority
BR
Brazil
Prior art keywords
oligopeptides
molecules
antiviral
antiviral effects
soluble
Prior art date
Application number
BR9814506-1A
Other languages
Portuguese (pt)
Inventor
Eberhard Bengsch
Antonius Kettrup
Juergen Polster
Original Assignee
Gsf Forschungszentrum Umwelt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gsf Forschungszentrum Umwelt filed Critical Gsf Forschungszentrum Umwelt
Publication of BR9814506A publication Critical patent/BR9814506A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"OLIGOPEPTìDIOS"<D>. A invenção refere-se a uma família de oligopeptídios com estrutura totalmente moderna, que aparece em geléais reais obtidas seletivamente de certa origem vegetal e está correlacionada com efeitos antivirais acentuados. A estrutura piloto é uma molécula com 52 aminoácidos. Do tipo de satélite existem para isso inúmeras moléculas análogas quase idênticas. As substâncias têm um amplo espectro de efeito antiviral, retrovírus inclusive e são humanamente atóxicos mesmo em altas doses. é surpreendente igualmente sua extrema resistência contra todas as proteases dirigidas e outras enzimas. As moléculas são aglomeradas em alto grau e inatacáveis. Apesar da aglomeração elas são geometricamente altamente flexíveis e podem formar várias conformações. Em estado nativo apresenta-se uma boa forma hidrossolúvel. Da síntese química resulta uma forma insolúvel na água, que no entanto, pode ser transformada em uma conformação bioativa solúvel, próxima à forma nativa. Os novos oligopeptídios reúnem assim, primeiramente e de ótima maneira todas as propriedades, que têm que ser exigidas por uma classe de substância ativa potencialmente antiviral.Invention Patent: <B> "OLIGOPEPTÍDIOS" <D>. The invention relates to a family of oligopeptides with a totally modern structure, which appears in real jellies obtained selectively from a certain plant origin and is correlated with marked antiviral effects. The pilot structure is a molecule with 52 amino acids. For the satellite type, there are countless analogous molecules that are almost identical. The substances have a wide spectrum of antiviral effects, including retroviruses and are humanly non-toxic even at high doses. its extreme resistance against all targeted proteases and other enzymes is also surprising. The molecules are agglomerated to a high degree and unassailable. Despite the agglomeration they are geometrically highly flexible and can form various conformations. In its native state, it presents a good water-soluble form. Chemical synthesis results in a water-insoluble form, which, however, can be transformed into a soluble bioactive conformation, close to the native form. The new oligopeptides thus bring together, in an optimal way, all the properties, which have to be demanded by a class of active substance potentially antiviral.

BR9814506-1A 1997-12-27 1998-12-02 Oligopetidians BR9814506A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997157932 DE19757932C2 (en) 1997-12-27 1997-12-27 Oligopeptides
PCT/EP1998/007811 WO1999033866A2 (en) 1997-12-27 1998-12-02 Antivirally active oligopeptide isolated from royal jelly

Publications (1)

Publication Number Publication Date
BR9814506A true BR9814506A (en) 2000-10-10

Family

ID=7853425

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814506-1A BR9814506A (en) 1997-12-27 1998-12-02 Oligopetidians

Country Status (4)

Country Link
EP (1) EP1042364A2 (en)
BR (1) BR9814506A (en)
DE (1) DE19757932C2 (en)
WO (1) WO1999033866A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10344561B4 (en) * 2003-09-25 2011-12-22 Eberhard Bengsch Use of a tetra-, penta- and octapeptide of royal jelly
JP2008208088A (en) * 2007-02-27 2008-09-11 Ehime Univ Composition for treatment of stomatitis
WO2018188714A2 (en) * 2018-09-06 2018-10-18 El Fiky Salem Ismaeil Salem Anti-leukemic, anti-hiv, and sialidase activities of royal-jelly proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1048323A (en) * 1989-06-28 1991-01-09 北京朝阳三益日用化学厂 Prevent and treat the preparation method of acquired immune deficiency syndrome (AIDS), sexually transmitted disease (STD) washing liquid
GB8917295D0 (en) * 1989-07-28 1989-09-13 Ruffles Graham K Anti-viral compositions
DE4232732C1 (en) * 1992-09-30 1994-02-03 Gsf Forschungszentrum Umwelt Standardized royal jelly, process for its production and its use

Also Published As

Publication number Publication date
DE19757932C2 (en) 2000-01-05
DE19757932A1 (en) 1999-07-08
EP1042364A2 (en) 2000-10-11
WO1999033866A2 (en) 1999-07-08
WO1999033866A3 (en) 1999-09-10

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Legal Events

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B08F Application fees: dismissal - article 86 of industrial property law

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