BR9814377A - Process for preparing isopropyl-methyl- [2- (3-propoxyphenoxy) ethyl] amine, compound, and, pharmaceutical formulation - Google Patents

Process for preparing isopropyl-methyl- [2- (3-propoxyphenoxy) ethyl] amine, compound, and, pharmaceutical formulation

Info

Publication number
BR9814377A
BR9814377A BR9814377-8A BR9814377A BR9814377A BR 9814377 A BR9814377 A BR 9814377A BR 9814377 A BR9814377 A BR 9814377A BR 9814377 A BR9814377 A BR 9814377A
Authority
BR
Brazil
Prior art keywords
propoxyphenoxy
ethyl
methyl
amine
pharmaceutical formulation
Prior art date
Application number
BR9814377-8A
Other languages
Portuguese (pt)
Inventor
Ulf Larsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR9814377A publication Critical patent/BR9814377A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE ISOPROPIL-METIL-[2-(3-PROPOXIFENóXI)ETIL]AMINA, COMPOSTO, E, FORMULAçãO FARMACêUTICA". A presente invenção refere-se a um novo processo para a síntese de isopropil -metil-[2-(3-n-propoxifenóxi) etil] amina. Além do mais, a presente invenção refere-se também a um novo intermediário e a uma etapa de purificação opcional no novo processo. Adicionalmente, a presente invenção também refere-se à fabricação de uma formulação farmacêutica contendo isopropil-metil-[2-(3-n-propoxifenóxi) etil] amina e ao uso de isopropil-metil-[2-(3-n-propoxifenóxi) etil] amina purificado em medicina."PROCESS FOR PREPARING ISOPROPIL-METHYL- [2- (3-PROPOXYphenoxy) ETHYL] AMINE, COMPOUND, AND, PHARMACEUTICAL FORMULATION". The present invention relates to a new process for the synthesis of isopropyl-methyl- [2- (3-n-propoxyphenoxy) ethyl] amine. Furthermore, the present invention also relates to a new intermediate and an optional purification step in the new process. In addition, the present invention also relates to the manufacture of a pharmaceutical formulation containing isopropyl-methyl- [2- (3-n-propoxyphenoxy) ethyl] amine and the use of isopropyl-methyl- [2- (3-n-propoxyphenoxy ) ethyl] amine purified in medicine.

BR9814377-8A 1997-12-22 1998-12-15 Process for preparing isopropyl-methyl- [2- (3-propoxyphenoxy) ethyl] amine, compound, and, pharmaceutical formulation BR9814377A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704834A SE9704834D0 (en) 1997-12-22 1997-12-22 New process
PCT/SE1998/002315 WO1999032430A1 (en) 1997-12-22 1998-12-15 Process for the preparation of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine

Publications (1)

Publication Number Publication Date
BR9814377A true BR9814377A (en) 2000-10-10

Family

ID=20409537

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814377-8A BR9814377A (en) 1997-12-22 1998-12-15 Process for preparing isopropyl-methyl- [2- (3-propoxyphenoxy) ethyl] amine, compound, and, pharmaceutical formulation

Country Status (21)

Country Link
EP (1) EP1045826A1 (en)
JP (1) JP2001526253A (en)
KR (1) KR20010024790A (en)
CN (1) CN1283177A (en)
AR (1) AR017198A1 (en)
AU (1) AU1989199A (en)
BR (1) BR9814377A (en)
CA (1) CA2314988A1 (en)
EE (1) EE200000369A (en)
HU (1) HUP0100616A2 (en)
ID (1) ID27591A (en)
IL (1) IL136825A0 (en)
IS (1) IS5523A (en)
NO (1) NO20002944L (en)
PL (1) PL341438A1 (en)
SE (1) SE9704834D0 (en)
SK (1) SK8052000A3 (en)
TR (1) TR200001976T2 (en)
TW (1) TW436474B (en)
WO (1) WO1999032430A1 (en)
ZA (1) ZA9811238B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2714639A1 (en) * 2011-05-26 2014-04-09 Solvay Specialty Polymers Italy S.p.A. Hydro-fluorocompounds
JP6247992B2 (en) * 2014-04-17 2017-12-13 株式会社ダイセル Method for producing halogen compound
JP6635999B2 (en) * 2017-10-13 2020-01-29 株式会社ダイセル Method for producing potassium salt, and potassium salt

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90704A (en) * 1989-06-21 1994-10-07 Makhteshim Chem Works Ltd Environmentally safe method of preparing n-n-propyl-n-2-(2, 4, 6-trichlorophenoxy)-ethyl amine
AR004691A1 (en) * 1995-10-27 1999-03-10 Astrazeneca Ab NEW DERIVATIVES OF [3-ALCOXI-PENOXI -) - ETIL] -DIALKYLAMINE, A PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, THEIR USE AS LOCAL ANESTHETICS AND A PROCEDURE FOR THEIR PREPARATION

Also Published As

Publication number Publication date
KR20010024790A (en) 2001-03-26
NO20002944D0 (en) 2000-06-08
TW436474B (en) 2001-05-28
EE200000369A (en) 2001-12-17
PL341438A1 (en) 2001-04-09
ZA9811238B (en) 1999-06-22
IS5523A (en) 2000-06-07
NO20002944L (en) 2000-06-08
SE9704834D0 (en) 1997-12-22
AR017198A1 (en) 2001-08-22
CA2314988A1 (en) 1999-07-01
TR200001976T2 (en) 2000-11-21
IL136825A0 (en) 2001-06-14
SK8052000A3 (en) 2001-02-12
ID27591A (en) 2001-04-12
JP2001526253A (en) 2001-12-18
HUP0100616A2 (en) 2002-05-29
EP1045826A1 (en) 2000-10-25
CN1283177A (en) 2001-02-07
WO1999032430A1 (en) 1999-07-01
AU1989199A (en) 1999-07-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.