BR9813303A - Compound, process for preparing it, use of it, processes for preparing a diastereomerically pure compound, and for preparing its salt, and pharmaceutical composition - Google Patents

Compound, process for preparing it, use of it, processes for preparing a diastereomerically pure compound, and for preparing its salt, and pharmaceutical composition

Info

Publication number
BR9813303A
BR9813303A BR9813303-9A BR9813303A BR9813303A BR 9813303 A BR9813303 A BR 9813303A BR 9813303 A BR9813303 A BR 9813303A BR 9813303 A BR9813303 A BR 9813303A
Authority
BR
Brazil
Prior art keywords
preparing
compound
hydrogen atom
salt
processes
Prior art date
Application number
BR9813303-9A
Other languages
Portuguese (pt)
Inventor
Patrice Mayer
Jean-Louis Vidaluc
Thierry Imbert
Marc Marien
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR9813303A publication Critical patent/BR9813303A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARá-LO, UTILIZAçãO DO MESMO, PROCESSOS DE PREPARAçãO DE UM COMPOSTO DIAESTEREOMERICAMENTE PURO, E DE PREPARAçãO DO SAL DESTE, E, COMPOSIçãO FARMACêUTICA" A invenção refere-se a novos derivados de 2-aminometil-benzo[a]quinolizidina, correspondendo à fórmula geral (I) em que: R~ 1~ representa ou um ou átomo de hidrogênio ou um grupo alquila com C~ 1-4~ ramificado, linear ou cíclico, um grupo hidroxi ou alcoxi com C~ 1~-C~ 4~ ramificado, linear ou cíclico, ou um átomo de halogênio, como F ou C1; R~ 2~ representa um átomo de hidrogênio ou um grupo alquila com C~ 1-6~; R~ 3~ representa um átomo de hidrogênio ou, ainda, pode constituir uma unidade (C=X)-NR~ 4~R~ 5~ e, neste caso, constitui uma uréia ou tiouréia com X = oxigênio ou enxofre; R~ 4~ e R~ 5~ podem ser, independentemente, um átomo de hidrogênio ou, ainda, um grupo alquila com C~ 1-8~ linear, ramificado, cíclico, um grupo arila, aralquila, aroíla, sendo que estes grupos arila também podem ser substituídos, R~ 4~ e R~ 5~ podem ser ligados por uma cadeia de carbono, incorporando eventualmente um heteroátomo."COMPOUND, PROCESS TO PREPARE IT, USE THE SAME, PROCESSES TO PREPARE A DIAESTEREOMERICALLY PURE COMPOUND, AND TO PREPARE THE SALT OF THIS, AND, PHARMACEUTICAL COMPOSITION" The invention relates to new 2-aminomethyl-benzo derivatives ] quinolizidine, corresponding to the general formula (I) where: R ~ 1 ~ represents either one or hydrogen atom or a branched, linear or cyclic C ~ 1-4 ~ alkyl group, a hydroxy or alkoxy group with C ~ 1 ~ -C ~ 4 ~ branched, linear or cyclic, or a halogen atom, such as F or C1; R ~ 2 ~ represents a hydrogen atom or a C ~ 1-6 ~ alkyl group; R ~ 3 ~ represents a hydrogen atom or, still, it can constitute a unit (C = X) -NR ~ 4 ~ R ~ 5 ~ and, in this case, it constitutes an urea or thiourea with X = oxygen or sulfur; R ~ 4 ~ and R ~ 5 ~ can be, independently, a hydrogen atom or, furthermore, a linear, branched, cyclic C ~ 1-8 ~ alkyl group, an aryl, aralkyl, and aryl group, these groups being aryl can also be substituted, R ~ 4 ~ and R ~ 5 ~ can be linked by a carbon chain, eventually incorporating a heteroatom.

BR9813303-9A 1997-10-28 1998-10-26 Compound, process for preparing it, use of it, processes for preparing a diastereomerically pure compound, and for preparing its salt, and pharmaceutical composition BR9813303A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9713499A FR2770215B1 (en) 1997-10-28 1997-10-28 AMINOMETHYL-BENZO [A] QUINOLIZIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION FOR NEURODEGENERATIVE DISEASES
PCT/FR1998/002281 WO1999021856A1 (en) 1997-10-28 1998-10-26 Aminomethyl-benzo[a]quinolizidine derivatives, preparation and therapeutic applications for neurodegenrative diseases

Publications (1)

Publication Number Publication Date
BR9813303A true BR9813303A (en) 2000-08-29

Family

ID=9512729

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813303-9A BR9813303A (en) 1997-10-28 1998-10-26 Compound, process for preparing it, use of it, processes for preparing a diastereomerically pure compound, and for preparing its salt, and pharmaceutical composition

Country Status (8)

Country Link
EP (1) EP1027350A1 (en)
JP (1) JP2001521034A (en)
CN (1) CN1278260A (en)
AU (1) AU9751798A (en)
BR (1) BR9813303A (en)
CA (1) CA2307748A1 (en)
FR (1) FR2770215B1 (en)
WO (1) WO1999021856A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
WO2006054793A1 (en) * 2004-11-19 2006-05-26 The New Industry Research Organization Benzofuran compound and pharmaceutical composition containing the same
EP2012833B1 (en) 2006-05-02 2014-10-29 The Trustees Of The University Of Pennsylvania Radiolabeled dihydrotrabenazine derivatives and their use as imaging agents
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
FR2976287B1 (en) 2011-06-09 2013-07-05 Pf Medicament BENZOQUINOLIZIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
US9115149B2 (en) * 2011-09-19 2015-08-25 Vitas Pharma Research Private Limited Heterocyclic compounds as inhibitors of fatty acid biosysnthesis for bacterial infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416432D0 (en) * 1984-06-28 1984-08-01 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
JP2001521034A (en) 2001-11-06
CN1278260A (en) 2000-12-27
FR2770215B1 (en) 2000-01-14
AU9751798A (en) 1999-05-17
WO1999021856A1 (en) 1999-05-06
FR2770215A1 (en) 1999-04-30
EP1027350A1 (en) 2000-08-16
CA2307748A1 (en) 1999-05-06

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired