BR9812579A - Bloqueadores de canal de ca 2+ do tipo r de estado regular especìfico e seu uso - Google Patents
Bloqueadores de canal de ca 2+ do tipo r de estado regular especìfico e seu usoInfo
- Publication number
- BR9812579A BR9812579A BR9812579-6A BR9812579A BR9812579A BR 9812579 A BR9812579 A BR 9812579A BR 9812579 A BR9812579 A BR 9812579A BR 9812579 A BR9812579 A BR 9812579A
- Authority
- BR
- Brazil
- Prior art keywords
- type
- channel
- blockers
- channel blockers
- mandevilla
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Patente de Invenção: <B>"BLOQUEADORES DE CANAL DE CA^ 2+^ DO TIPO R DE ESTADO REGULAR ESPECìFICO E SEU USO"<D>. A presente invenção refere-se a bloqueadores de canal de Ca^ 2+^ e mais particularmente a bloqueadores de canal de Ca^ 2+^ do tipo R. Mais especificamente, a invenção refere-se à atividade de bloqueio de canal de Ca^ 2+^ da Mandevilla velutina e da Mandevilla illustris. A presente invenção refere-se ainda a compostos do tipo saponina isolados da espécie de Mandevilla. A presente invenção também refere-se ao tratamento de várias patologias que envolvem o canal de Ca^ 2+^ do tipo R de estado regulado não-sensível à nifedipina mas sensível à isradipina e ao uso de bloqueadores de canal Ca^ 2+^ do tipo R de estado regulado no tratamento dessas patologias.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002217088A CA2217088A1 (en) | 1997-09-30 | 1997-09-30 | New mandevilla velutina derivatives as steady-state r-type ca2+ channel blockers, method of making and use thereof |
| PCT/CA1998/000908 WO1999016449A1 (en) | 1997-09-30 | 1998-09-28 | SPECIFIC STEADY-STATE R-TYPE Ca2+ CHANNEL BLOCKERS AND USE THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9812579A true BR9812579A (pt) | 2000-07-25 |
Family
ID=4161555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9812579-6A BR9812579A (pt) | 1997-09-30 | 1998-09-28 | Bloqueadores de canal de ca 2+ do tipo r de estado regular especìfico e seu uso |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1028734B1 (pt) |
| AT (1) | ATE318142T1 (pt) |
| AU (1) | AU9248998A (pt) |
| BR (1) | BR9812579A (pt) |
| CA (1) | CA2217088A1 (pt) |
| DE (1) | DE69833557T2 (pt) |
| WO (1) | WO1999016449A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| BR0107933A (pt) * | 2000-01-28 | 2004-01-06 | Procter & Gamble | Compostos de arginina saborosos e seus usos para saúde cardiovascular |
| US9808011B2 (en) | 2014-12-15 | 2017-11-07 | Biovectra Inc. | Pentacyclic triterpene compounds and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0359310A1 (en) * | 1988-09-15 | 1990-03-21 | The Procter & Gamble Company | Extracts of mandevilla pentlandiana useful as bradykinin antagonists |
-
1997
- 1997-09-30 CA CA002217088A patent/CA2217088A1/en not_active Abandoned
-
1998
- 1998-09-28 WO PCT/CA1998/000908 patent/WO1999016449A1/en active IP Right Grant
- 1998-09-28 BR BR9812579-6A patent/BR9812579A/pt not_active Application Discontinuation
- 1998-09-28 DE DE69833557T patent/DE69833557T2/de not_active Expired - Lifetime
- 1998-09-28 AT AT98944936T patent/ATE318142T1/de not_active IP Right Cessation
- 1998-09-28 EP EP98944936A patent/EP1028734B1/en not_active Expired - Lifetime
- 1998-09-28 AU AU92489/98A patent/AU9248998A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU9248998A (en) | 1999-04-23 |
| ATE318142T1 (de) | 2006-03-15 |
| DE69833557D1 (de) | 2006-04-27 |
| CA2217088A1 (en) | 1999-03-30 |
| WO1999016449A1 (en) | 1999-04-08 |
| EP1028734A1 (en) | 2000-08-23 |
| EP1028734B1 (en) | 2006-02-22 |
| DE69833557T2 (de) | 2006-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI |