BR9812321A - Modulation of immune responses - Google Patents
Modulation of immune responsesInfo
- Publication number
- BR9812321A BR9812321A BR9812321-1A BR9812321A BR9812321A BR 9812321 A BR9812321 A BR 9812321A BR 9812321 A BR9812321 A BR 9812321A BR 9812321 A BR9812321 A BR 9812321A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- immune
- modulation
- alkenyl
- animal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>"MODULAçãO DE RESPOSTAS IMUNOLóGICAS"<D>. Um processo de afetar ou de modular para estímulo ou supressão do produto da célula imunológica de acordo com uma resposta inunológica a um estimulante imunológico externo ou endógeno em um animal que compreende as etapas de administração a tal animal de uma quantidade eficaz moduladora imune não-tóxica de um composto selecionado do grupo que consiste em compostos de fórmula geral (I) R~ 1~-CO-NR~ 2~R~ 3~ em que R~ 1~ é selecionado do grupo que consiste em H e grupos alquila inferior (isto é, C~ 1~ a C~ 3~) e C~ 2~ a C~ 3~ alquenila; R~ 2~ e R~ 3~ são os mesmos ou diferentes e cada um é selecionado do grupo que consiste em H, grupos alquila inferior (isto é, C~ 1~ a C~ 3~) e C~ 2~ a C~ 3~ alquenila que podem opcionalmente ser halogenados ou hidroxilados ou que podem em combinação um com o outro formar um grupo -(CH~ 2~)<B>~ n~<D>- em que n é qualquer número de 2 a 5 ou o grupo -(CH~ 2~)~ 2~-O-(CH~ 2~)~ 2~ e metabólitos e pró-drogas dos mesmos. O processo é útil no tratamento de uma variedade de enfermidades associadas a respostas imunológicas inapropriadas e a invenção fornece o uso de compostos de Fórmula (I) na fabricação de medicamentos para uso no tratamento de tais enfermidades e para preparações farmacêuticas que contêm os mesmos.Invention Patent: <B> "MODULATION OF IMMUNOLOGICAL RESPONSES" <D>. A process of affecting or modulating to stimulate or suppress the immune cell product in accordance with an inunological response to an external or endogenous immune stimulant in an animal comprising the steps of administering to such an animal a non-toxic immune modulating effective amount of a compound selected from the group consisting of compounds of the general formula (I) R ~ 1 ~ -CO-NR ~ 2 ~ R ~ 3 ~ where R ~ 1 ~ is selected from the group consisting of H and lower alkyl groups ( i.e., C ~ 1 ~ to C ~ 3 ~) and C ~ 2 ~ to C ~ 3 ~ alkenyl; R ~ 2 ~ and R ~ 3 ~ are the same or different and each is selected from the group consisting of H, lower alkyl groups (ie, C ~ 1 ~ to C ~ 3 ~) and C ~ 2 ~ to C ~ 3 ~ alkenyl which can optionally be halogenated or hydroxylated or which can in combination with one another form a group - (CH ~ 2 ~) <B> ~ n ~ <D> - where n is any number from 2 to 5 or the group - (CH ~ 2 ~) ~ 2 ~ -O- (CH ~ 2 ~) ~ 2 ~ and their metabolites and prodrugs. The process is useful in the treatment of a variety of diseases associated with inappropriate immune responses and the invention provides the use of compounds of Formula (I) in the manufacture of medicaments for use in the treatment of such diseases and for pharmaceutical preparations containing them.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA978319 | 1997-09-16 | ||
| PCT/US1998/019126 WO1999013885A1 (en) | 1997-09-16 | 1998-09-16 | Modulation of immune responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9812321A true BR9812321A (en) | 2000-09-05 |
Family
ID=25586589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9812321-1A BR9812321A (en) | 1997-09-16 | 1998-09-16 | Modulation of immune responses |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1019063A4 (en) |
| JP (1) | JP2001516721A (en) |
| CN (1) | CN1279612A (en) |
| AU (1) | AU737867B2 (en) |
| BR (1) | BR9812321A (en) |
| CA (1) | CA2304119A1 (en) |
| IL (1) | IL135091A0 (en) |
| NO (1) | NO20001341L (en) |
| NZ (1) | NZ503418A (en) |
| WO (1) | WO1999013885A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2324631A1 (en) * | 2000-10-26 | 2002-04-26 | Virodene Pharmaceutical Holdings (Proprietary) Limited | A substance or composition for the treatment of cancer |
| AP2006003648A0 (en) * | 2003-12-05 | 2006-06-30 | Namibia Medical Invest Pty Ltd | Patch |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5814659A (en) * | 1996-04-23 | 1998-09-29 | Dtr Dermal Therapy (Barbados) Inc. | Topical analgesic composition |
-
1998
- 1998-09-16 WO PCT/US1998/019126 patent/WO1999013885A1/en not_active Application Discontinuation
- 1998-09-16 CA CA002304119A patent/CA2304119A1/en not_active Abandoned
- 1998-09-16 NZ NZ503418A patent/NZ503418A/en not_active IP Right Cessation
- 1998-09-16 CN CN98810397A patent/CN1279612A/en active Pending
- 1998-09-16 EP EP98946998A patent/EP1019063A4/en not_active Withdrawn
- 1998-09-16 BR BR9812321-1A patent/BR9812321A/en not_active IP Right Cessation
- 1998-09-16 AU AU93890/98A patent/AU737867B2/en not_active Ceased
- 1998-09-16 JP JP2000511505A patent/JP2001516721A/en active Pending
- 1998-09-16 IL IL13509198A patent/IL135091A0/en unknown
-
2000
- 2000-03-15 NO NO20001341A patent/NO20001341L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU737867B2 (en) | 2001-09-06 |
| JP2001516721A (en) | 2001-10-02 |
| CN1279612A (en) | 2001-01-10 |
| EP1019063A4 (en) | 2003-09-03 |
| NO20001341L (en) | 2000-05-16 |
| NZ503418A (en) | 2001-02-23 |
| AU9389098A (en) | 1999-04-05 |
| WO1999013885A1 (en) | 1999-03-25 |
| EP1019063A1 (en) | 2000-07-19 |
| CA2304119A1 (en) | 1999-03-25 |
| NO20001341D0 (en) | 2000-03-15 |
| IL135091A0 (en) | 2001-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |