BR9809596A - Piperidine compounds, optical isomer or mixture of optical isomers, pharmaceutical composition, use of a compound, and, processes for treating or preventing diseases of the endocrinological system and for treating or preventing non-insulin dependent diabetes (niddm or type 2 diabetes) and / or treatment or prevention of long-term complications - Google Patents

Piperidine compounds, optical isomer or mixture of optical isomers, pharmaceutical composition, use of a compound, and, processes for treating or preventing diseases of the endocrinological system and for treating or preventing non-insulin dependent diabetes (niddm or type 2 diabetes) and / or treatment or prevention of long-term complications

Info

Publication number
BR9809596A
BR9809596A BR9809596-0A BR9809596A BR9809596A BR 9809596 A BR9809596 A BR 9809596A BR 9809596 A BR9809596 A BR 9809596A BR 9809596 A BR9809596 A BR 9809596A
Authority
BR
Brazil
Prior art keywords
treatment
treating
prevention
diabetes
long
Prior art date
Application number
BR9809596-0A
Other languages
Portuguese (pt)
Inventor
Marit Kristiansen
Palle Jakobsen
Jane Maria Lundbeck
Birgitte Sokilde
Karsten Lundgren
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority claimed from PCT/DK1998/000177 external-priority patent/WO1998050359A1/en
Publication of BR9809596A publication Critical patent/BR9809596A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"COMPOSTOS DE PIPERIDINA, ISÈMERO óPTICO OU MISTURA DE ISÈMEROS óPTICOS, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSOS PARA TRATAMENTO OU PREVENçãO DE DOENçAS DO SISTEMA ENDOCRINOLóGICO E PARA TRATAMENTO OU PREVENçãO DE DIABETES NãO DEPENDENTE DE INSULINA (NIDDM OU DIABETES TIPO 2) E/OU TRATAMENTO OU PREVENçãO DE COMPLICAçõES A LONGO PRAZO" São fornecidos novos compostos de piperidina, e esses compostos são úteis no tratamento e/ou prevenção de diabetes, e especialmente diabetes não dependentes de insulina (NIDDM ou diabetes tipo 2) incluindo tratamento durante a noite ou nas refeições e tratamento ou prevenção de complicações a longo prazo, tais como retinopatia, neuropatia e micro- e macro-angiopatia; tratamento de hiperglicemia, hipercolesterolemia, hipertensão, hiperinsulinemia, hiperlipidemia, aterosclerose ou isquemia miocardial."PIPERIDINE COMPOUNDS, OPTICAL ISOMETER OR MIXTURE OF OPTICAL ISOMERS, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, AND, PROCESSES FOR TREATING OR PREVENTING DISEASES OF THE ENDOCRINOLOGICAL SYSTEM AND FOR TREATMENT OR PREVENTION OF A PREVIOUS DEDENTY OF A DIABETIC DEPARTMENT OF A DAY OF PREVIOUS PREVENTION. ) AND / OR TREATMENT OR PREVENTION OF LONG TERM COMPLICATIONS "New piperidine compounds are provided, and these compounds are useful in the treatment and / or prevention of diabetes, and especially non-insulin dependent diabetes (NIDDM or type 2 diabetes) including treatment at night or with meals and treatment or prevention of long-term complications, such as retinopathy, neuropathy and micro- and macro-angiopathy; treatment of hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis or myocardial ischemia.

BR9809596-0A 1997-05-06 1998-05-06 Piperidine compounds, optical isomer or mixture of optical isomers, pharmaceutical composition, use of a compound, and, processes for treating or preventing diseases of the endocrinological system and for treating or preventing non-insulin dependent diabetes (niddm or type 2 diabetes) and / or treatment or prevention of long-term complications BR9809596A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK52697 1997-05-06
PCT/DK1998/000177 WO1998050359A1 (en) 1997-05-06 1998-05-06 Novel heterocyclic compounds

Publications (1)

Publication Number Publication Date
BR9809596A true BR9809596A (en) 2000-07-04

Family

ID=8094549

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809596-0A BR9809596A (en) 1997-05-06 1998-05-06 Piperidine compounds, optical isomer or mixture of optical isomers, pharmaceutical composition, use of a compound, and, processes for treating or preventing diseases of the endocrinological system and for treating or preventing non-insulin dependent diabetes (niddm or type 2 diabetes) and / or treatment or prevention of long-term complications

Country Status (9)

Country Link
JP (1) JP2002515064A (en)
KR (1) KR20010012299A (en)
CN (1) CN1306511A (en)
AU (1) AU741660B2 (en)
BR (1) BR9809596A (en)
CA (1) CA2289001A1 (en)
NO (1) NO995430L (en)
PL (1) PL336639A1 (en)
ZA (1) ZA983800B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2096111A1 (en) 2006-11-20 2009-09-02 Japan Tobacco Inc. Pyrazoles and use thereof as drugs
CN102093260B (en) * 2009-12-14 2014-03-05 太景生物科技股份有限公司 Stereospecific synthesis of piperidine derivative

Also Published As

Publication number Publication date
NO995430D0 (en) 1999-11-05
AU741660B2 (en) 2001-12-06
ZA983800B (en) 1998-11-06
AU7205898A (en) 1998-11-27
CA2289001A1 (en) 1998-11-12
NO995430L (en) 1999-11-05
KR20010012299A (en) 2001-02-15
JP2002515064A (en) 2002-05-21
CN1306511A (en) 2001-08-01
PL336639A1 (en) 2000-07-03

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.