BR9807397A - 4-Aminoethoxyindazole derivatives - Google Patents

4-Aminoethoxyindazole derivatives

Info

Publication number
BR9807397A
BR9807397A BR9807397-4A BR9807397A BR9807397A BR 9807397 A BR9807397 A BR 9807397A BR 9807397 A BR9807397 A BR 9807397A BR 9807397 A BR9807397 A BR 9807397A
Authority
BR
Brazil
Prior art keywords
derivatives
alkoxy
halogen
phenyl
alkyl
Prior art date
Application number
BR9807397-4A
Other languages
Portuguese (pt)
Inventor
Richard Eric Mewshaw
Anthonie Johan Verwijs
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9807397A publication Critical patent/BR9807397A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Patente de Invenção: <B>"DERIVADOS 4-AMINOETOXIINDAZOL"<D>. Esta invenção refere-se a agonistas D~ 2~ de dopamina de fórmula (I), em que: 'Y é hidrogênio, halogênio, ou C~ 1-6 alcóxi; R^ 1^ é hidrogênio ou C~ 1-6~ alquila; X é metileno, oxigênio ou carbonila; Ar é fenila ou tienila, cada um opcionalmente substituído com 1-2 grupos independentemente selecionado dentre C~ 1-6~ alcóxi, C~ 1-6~ alquila, halogênio, trifluormetila, e fenila; n = 0-4, ou sais farmaceuticamente aceitáveis destes. Os agonistas D~ 2~ da dopamina são úteis no tratamento da esquizofrenia, síndrome de Tourette, alcoolismo e toxicomania; e são também úteis para o tratamento da doença de Parkinson.Invention Patent: <B> "4-AMINOETOXYINDAZOL DERIVATIVES" <D>. This invention relates to D ~ 2 ~ dopamine agonists of formula (I), wherein: 'Y is hydrogen, halogen, or C ~ 1-6 alkoxy; R ^ 1 ^ is hydrogen or C ~ 1-6 ~ alkyl; X is methylene, oxygen or carbonyl; Ar is phenyl or thienyl, each optionally substituted with 1-2 groups independently selected from C ~ 1-6 ~ alkoxy, C ~ 1-6 ~ alkyl, halogen, trifluoromethyl, and phenyl; n = 0-4, or pharmaceutically acceptable salts thereof. D ~ 2 ~ dopamine agonists are useful in the treatment of schizophrenia, Tourette's syndrome, alcoholism and drug addiction; and are also useful for the treatment of Parkinson's disease.

BR9807397-4A 1997-02-18 1998-02-13 4-Aminoethoxyindazole derivatives BR9807397A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80132597A 1997-02-18 1997-02-18
PCT/US1998/002413 WO1998035943A1 (en) 1997-02-18 1998-02-13 4-aminoethoxyindazole derivatives

Publications (1)

Publication Number Publication Date
BR9807397A true BR9807397A (en) 2000-03-14

Family

ID=25180801

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807397-4A BR9807397A (en) 1997-02-18 1998-02-13 4-Aminoethoxyindazole derivatives

Country Status (11)

Country Link
EP (1) EP0960101A1 (en)
JP (1) JP2001512458A (en)
KR (1) KR20000071125A (en)
CN (1) CN1248246A (en)
AR (1) AR011137A1 (en)
AU (2) AU6246198A (en)
BR (1) BR9807397A (en)
CA (1) CA2278746A1 (en)
IL (1) IL131159A0 (en)
WO (2) WO1998035942A1 (en)
ZA (1) ZA981307B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005008954D1 (en) * 2004-05-26 2008-09-25 Pfizer INDAZOL AND INDOLON DERIVATIVE AND THEIR USE AS PHARMACEUTICALS
RU2719446C2 (en) * 2014-11-03 2020-04-17 Айомет Фарма Лтд Pharmaceutical compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
EP0960101A1 (en) 1999-12-01
CN1248246A (en) 2000-03-22
IL131159A0 (en) 2001-01-28
JP2001512458A (en) 2001-08-21
KR20000071125A (en) 2000-11-25
ZA981307B (en) 1999-08-17
WO1998035942A1 (en) 1998-08-20
WO1998035943A1 (en) 1998-08-20
AR011137A1 (en) 2000-08-02
CA2278746A1 (en) 1998-08-20
AU6246198A (en) 1998-09-08
AU6273398A (en) 1998-09-08

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]