BR9803180A - 1,4-dihydropyridine compounds optically active as bradykinin antagonists. - Google Patents

1,4-dihydropyridine compounds optically active as bradykinin antagonists.

Info

Publication number
BR9803180A
BR9803180A BR9803180A BR9803180A BR9803180A BR 9803180 A BR9803180 A BR 9803180A BR 9803180 A BR9803180 A BR 9803180A BR 9803180 A BR9803180 A BR 9803180A BR 9803180 A BR9803180 A BR 9803180A
Authority
BR
Brazil
Prior art keywords
substituted
optically active
unsubstituted
bradykinin antagonists
dihydropyridine compounds
Prior art date
Application number
BR9803180A
Other languages
Portuguese (pt)
Inventor
Takafumi Ikeda
Mitsuhiro Kawamura
Yu-Ting-Ge
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB1997/000010 external-priority patent/WO1997025411A1/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR9803180A publication Critical patent/BR9803180A/en

Links

Abstract

Patente de Invenção: <B>"COMPOSTOS DE 1,4-DI-HIDROeitáveis, em que A^ 1^ e A^ 2^ são, cada um, halo;substituída; Y é um grupo heterocíclico selecionado a partir de C~ 5-10~ azacicloalquila, C~ 6-10~ diazacicloalquila, C~ 7-10~ azabicicloalquila e similares; e R^ 4^ é selecionado a partir do seguinte (a) C~ 1-8~ alquila substituído ou não-substituído; (b) amino substituída ou não-substituída; (c) Cd) C~ 3-8~ cicloalquila ou C~ 7-14~ bicicloalquila, substituída ou não-substituída; (e) C~ 5-10~ azacicloalquila ou C~ 6-10~ diazacicloalquila, substidi-azabicicloalquila, substituída ou não-substituí condições médicas causadas pela bradicinina tal como inflamação, doença cardiovascular, dor, etc. Entermediários dos compostos acima referidos.Patent of Invention: <B> "Compounds of 1,4-DI-HYDRO-eligible, where A ^ 1 ^ and A ^ 2 ^ are each halo; substituted; Y is a heterocyclic group selected from C ~ 5 -10 ~ azacycloalkyl, C ~ 6-10 ~ diazacycloalkyl, C ~ 7-10 ~ azabicycloalkyl and the like, and R ^ 4 ^ is selected from the following (a) substituted or unsubstituted C ~ 1-8 ~ alkyl; (b) substituted or unsubstituted amino; (c) Cd) C ~ 3-8 ~ cycloalkyl or C ~ 7-14 ~ bicycloalkyl, substituted or unsubstituted; (e) C ~ 5-10 ~ azacycloalkyl or C ~ 6-10 ~ diazacycloalkyl, substituted-azabicycloalkyl, substituted or unsubstituted medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. Intermediates of the above compounds.

BR9803180A 1997-01-10 1998-08-18 1,4-dihydropyridine compounds optically active as bradykinin antagonists. BR9803180A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1997/000010 WO1997025411A1 (en) 1996-01-11 1997-01-10 A bio-enhancer

Publications (1)

Publication Number Publication Date
BR9803180A true BR9803180A (en) 2000-03-21

Family

ID=11004517

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9803180A BR9803180A (en) 1997-01-10 1998-08-18 1,4-dihydropyridine compounds optically active as bradykinin antagonists.

Country Status (1)

Country Link
BR (1) BR9803180A (en)

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Legal Events

Date Code Title Description
B07A Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal

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