BR9803180A - 1,4-dihydropyridine compounds optically active as bradykinin antagonists. - Google Patents
1,4-dihydropyridine compounds optically active as bradykinin antagonists.Info
- Publication number
- BR9803180A BR9803180A BR9803180A BR9803180A BR9803180A BR 9803180 A BR9803180 A BR 9803180A BR 9803180 A BR9803180 A BR 9803180A BR 9803180 A BR9803180 A BR 9803180A BR 9803180 A BR9803180 A BR 9803180A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- optically active
- unsubstituted
- bradykinin antagonists
- dihydropyridine compounds
- Prior art date
Links
Abstract
Patente de Invenção: <B>"COMPOSTOS DE 1,4-DI-HIDROeitáveis, em que A^ 1^ e A^ 2^ são, cada um, halo;substituída; Y é um grupo heterocíclico selecionado a partir de C~ 5-10~ azacicloalquila, C~ 6-10~ diazacicloalquila, C~ 7-10~ azabicicloalquila e similares; e R^ 4^ é selecionado a partir do seguinte (a) C~ 1-8~ alquila substituído ou não-substituído; (b) amino substituída ou não-substituída; (c) Cd) C~ 3-8~ cicloalquila ou C~ 7-14~ bicicloalquila, substituída ou não-substituída; (e) C~ 5-10~ azacicloalquila ou C~ 6-10~ diazacicloalquila, substidi-azabicicloalquila, substituída ou não-substituí condições médicas causadas pela bradicinina tal como inflamação, doença cardiovascular, dor, etc. Entermediários dos compostos acima referidos.Patent of Invention: <B> "Compounds of 1,4-DI-HYDRO-eligible, where A ^ 1 ^ and A ^ 2 ^ are each halo; substituted; Y is a heterocyclic group selected from C ~ 5 -10 ~ azacycloalkyl, C ~ 6-10 ~ diazacycloalkyl, C ~ 7-10 ~ azabicycloalkyl and the like, and R ^ 4 ^ is selected from the following (a) substituted or unsubstituted C ~ 1-8 ~ alkyl; (b) substituted or unsubstituted amino; (c) Cd) C ~ 3-8 ~ cycloalkyl or C ~ 7-14 ~ bicycloalkyl, substituted or unsubstituted; (e) C ~ 5-10 ~ azacycloalkyl or C ~ 6-10 ~ diazacycloalkyl, substituted-azabicycloalkyl, substituted or unsubstituted medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. Intermediates of the above compounds.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB1997/000010 WO1997025411A1 (en) | 1996-01-11 | 1997-01-10 | A bio-enhancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9803180A true BR9803180A (en) | 2000-03-21 |
Family
ID=11004517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9803180A BR9803180A (en) | 1997-01-10 | 1998-08-18 | 1,4-dihydropyridine compounds optically active as bradykinin antagonists. |
Country Status (1)
Country | Link |
---|---|
BR (1) | BR9803180A (en) |
-
1998
- 1998-08-18 BR BR9803180A patent/BR9803180A/en not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Technical examination (opinion): publication of technical examination (opinion) | ||
B09B | Decision: refusal |
Free format text: INDEFIRO PELO PRESENTE PEDIDO DE PATENTE DE ACORDO COM ARTIGO 8O DA LPI. |