BR9712298A - Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion protein - Google Patents
Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion proteinInfo
- Publication number
- BR9712298A BR9712298A BR9712298-0A BR9712298A BR9712298A BR 9712298 A BR9712298 A BR 9712298A BR 9712298 A BR9712298 A BR 9712298A BR 9712298 A BR9712298 A BR 9712298A
- Authority
- BR
- Brazil
- Prior art keywords
- tuberculosis
- polypeptide
- expression vector
- biological sample
- recombinant expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"POLIPEPTìDEO, MOLéCULA DE DNA, VETOR DE EXPRESSãO RECOMBINANTE, CéLULA HOSPEDEIRA, PROCESSO PARA DETECTAR INFECçãO POR M. TUBERCULOSIS EM UMA AMOSTRA BIOLóGICA, KIT DIAGNóSTICO, ANTICORPOS MONOCLONAL, E, POLICLONAL, E, PROTEìNA DE FUSãO". Compostos e processos para diagnosticar tuberculose são descritos. Os compostos providos incluem polipeptídeos que contém pelo menos uma porção antigênica de uma ou mais proteínas de M. tuberculosis , e sequências de DNA codificando estes polipeptídeo s. Os kits diagnósticos contendo estes polipeptídeos ou sequências de DNA e um reagente de detecção apropriado podem ser usados para detecção de infecção por M. tuberculosis em pacientes e amostras biológicas. Os anticorpos dirigidos contra estes polipeptídeos são também providos."POLYPEPTIDE, DNA MOLECULE, RECOMBINANT EXPRESSION VECTOR, HOSTING CELL, PROCESS TO DETECT INFECTION BY M. TUBERCULOSIS IN A BIOLOGICAL SAMPLE, DIAGNOSTIC KIT, MONOCLONAL ANTIBODIES, AND, POLYCLEAN, AND, POLYCLEAN. Compounds and processes for diagnosing tuberculosis are described. The compounds provided include polypeptides that contain at least an antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding these polypeptides. Diagnostic kits containing these polypeptides or DNA sequences and an appropriate detection reagent can be used to detect M. tuberculosis infection in patients and biological samples. Antibodies directed against these polypeptides are also provided.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72962296A | 1996-10-11 | 1996-10-11 | |
US08/818,111 US6338852B1 (en) | 1995-09-01 | 1997-03-13 | Compounds and methods for diagnosis of tuberculosis |
PCT/US1997/018214 WO1998016645A2 (en) | 1996-10-11 | 1997-10-07 | Compounds and methods for diagnosis of tuberculosis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712298A true BR9712298A (en) | 2000-10-24 |
Family
ID=27111919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712298-0A BR9712298A (en) | 1996-10-11 | 1997-10-07 | Polypeptide, DNA molecule, recombinant expression vector, host cell, process to detect infection by m. tuberculosis in a biological sample, diagnostic kit, monoclonal, and, polyclonal, and, fusion protein |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0934415A2 (en) |
JP (1) | JP2001500383A (en) |
AU (1) | AU4750597A (en) |
BR (1) | BR9712298A (en) |
CA (1) | CA2268036A1 (en) |
CZ (1) | CZ126699A3 (en) |
IL (2) | IL129389A0 (en) |
NO (1) | NO991693L (en) |
PL (1) | PL333304A1 (en) |
TR (1) | TR199901569T2 (en) |
WO (1) | WO1998016645A2 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6991797B2 (en) | 1993-07-02 | 2006-01-31 | Statens Serum Institut | M. tuberculosis antigens |
US6982085B2 (en) | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
US6613881B1 (en) * | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
WO1999004005A1 (en) * | 1997-07-16 | 1999-01-28 | Institut Pasteur | A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same |
EP1484405A1 (en) * | 1997-11-10 | 2004-12-08 | Statens Serum Institut | Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis |
US6465633B1 (en) | 1998-12-24 | 2002-10-15 | Corixa Corporation | Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis |
US20030027774A1 (en) * | 1999-03-18 | 2003-02-06 | Ronald C. Hendrickson | Tuberculosis antigens and methods of use therefor |
ATE429245T1 (en) | 1999-05-04 | 2009-05-15 | Univ New Jersey Med | PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES |
US7009042B1 (en) | 1999-10-07 | 2006-03-07 | Corixa Corporation | Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins |
CA2386854A1 (en) * | 1999-10-07 | 2001-04-12 | Corixa Corporation | Methods of using a mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of heterologous proteins |
US6316205B1 (en) | 2000-01-28 | 2001-11-13 | Genelabs Diagnostics Pte Ltd. | Assay devices and methods of analyte detection |
AU2001241738A1 (en) | 2000-02-25 | 2001-09-03 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
AU2001268678B2 (en) | 2000-06-20 | 2006-11-16 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
AU2001271963A1 (en) * | 2000-07-10 | 2002-01-21 | Colorado State University Research Foundation | Mid-life vaccine and methods for boosting anti-mycobacterial immunity |
JP2005504523A (en) | 2001-06-22 | 2005-02-17 | ヘルス プロテクション エージェンシー | Mycobacterial antigen expressed under hypoxic pressure |
US7393540B2 (en) | 2001-07-04 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed during latency |
TWI243855B (en) * | 2001-07-25 | 2005-11-21 | Tosoh Corp | Oligonucleotides and process for detecting mycobacterium tuberculosis |
GB0125535D0 (en) * | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
US7026465B2 (en) | 2002-02-15 | 2006-04-11 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis |
US8475735B2 (en) | 2004-11-01 | 2013-07-02 | Uma Mahesh Babu | Disposable immunodiagnostic test system |
SG159554A1 (en) | 2004-11-16 | 2010-03-30 | Crucell Holland Bv | Multivalent vaccines comprising recombinant viral vectors |
CN106390108B (en) | 2005-04-29 | 2020-09-08 | 葛兰素史密丝克莱恩生物有限公司 | Novel method for preventing or treating mycobacterium tuberculosis infection |
EP1945755B1 (en) * | 2005-07-26 | 2015-01-14 | Rutgers, the State University of New Jersey | Antibody profiles characteristic of tuberculosis state |
CN100999550B (en) | 2006-01-10 | 2010-10-06 | 中国人民解放军第三○九医院 | Tubercle branch bacillus fusion protein and application thereof |
GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
WO2008140478A2 (en) * | 2006-11-01 | 2008-11-20 | Immport Therapeutics, Inc. | Compositions and methods for immunodominant antigens |
BR112012018669A2 (en) | 2010-01-27 | 2017-09-05 | Glaxosmithkline Biologicals Sa | MODIFIED RV3616C PROTEIN, USE OF A MODIFIED RV3616C PROTEIN, POLYNUCLEOTIDE, USE OF A POLYNUCLEOTIDE, PHARMACEUTICAL COMPOSITION, IMMUNOGENIC COMPOSITION, FUSION PROTEIN, AND, POLYPEPTIDE. |
CN115746092A (en) * | 2022-08-12 | 2023-03-07 | 齐鲁工业大学 | Spirulina platensis phycocyanin active peptide with antioxidant and anti-aging activities and application thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2244539A1 (en) * | 1973-07-13 | 1975-04-18 | Mitsui Pharmaceuticals | Tuberculin active proteins and peptides prepn - from tubercle bacillus |
FR2265402A1 (en) * | 1974-03-29 | 1975-10-24 | Mitsui Pharmaceuticals | Tuberculin active proteins and peptides prepn - from tubercle bacillus |
EP0419355B1 (en) * | 1989-09-19 | 2000-02-09 | N.V. Innogenetics S.A. | Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis |
FR2677365B1 (en) * | 1991-06-07 | 1995-08-04 | Pasteur Institut | MYCOBACTERIUM PROTEINS AND APPLICATIONS. |
US5330754A (en) * | 1992-06-29 | 1994-07-19 | Archana Kapoor | Membrane-associated immunogens of mycobacteria |
DK79793D0 (en) * | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | DIAGNOSTIC TEST |
DK79893D0 (en) * | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | NEW VACCINE |
US5714593A (en) * | 1995-02-01 | 1998-02-03 | Institut Pasteur | DNA from mycobacterium tuberculosis which codes for a 45/47 kilodalton protein |
ATE323165T1 (en) * | 1995-09-01 | 2006-04-15 | Corixa Corp | COMPOUNDS AND METHODS FOR IMMUNOTHERAPY AND DIAGNOSIS OF TUBERCULOSIS |
ES2378051T3 (en) * | 1995-09-01 | 2012-04-04 | Corixa Corporation | COMPOUNDS AND METHODS FOR THE DIAGNOSIS OF TUBERCOLOSIS. |
-
1997
- 1997-10-07 EP EP97910030A patent/EP0934415A2/en not_active Withdrawn
- 1997-10-07 CA CA002268036A patent/CA2268036A1/en not_active Abandoned
- 1997-10-07 WO PCT/US1997/018214 patent/WO1998016645A2/en not_active Application Discontinuation
- 1997-10-07 JP JP10518432A patent/JP2001500383A/en not_active Ceased
- 1997-10-07 IL IL12938997A patent/IL129389A0/en unknown
- 1997-10-07 PL PL97333304A patent/PL333304A1/en unknown
- 1997-10-07 AU AU47505/97A patent/AU4750597A/en not_active Abandoned
- 1997-10-07 CZ CZ991266A patent/CZ126699A3/en unknown
- 1997-10-07 BR BR9712298-0A patent/BR9712298A/en unknown
- 1997-10-07 TR TR1999/01569T patent/TR199901569T2/en unknown
- 1997-10-09 IL IL12193697A patent/IL121936A0/en unknown
-
1999
- 1999-04-09 NO NO991693A patent/NO991693L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2268036A1 (en) | 1998-04-23 |
WO1998016645A2 (en) | 1998-04-23 |
IL121936A0 (en) | 1998-03-10 |
NO991693D0 (en) | 1999-04-09 |
IL129389A0 (en) | 2000-02-17 |
WO1998016645A3 (en) | 1998-08-06 |
TR199901569T2 (en) | 2000-12-21 |
NO991693L (en) | 1999-06-09 |
AU4750597A (en) | 1998-05-11 |
CZ126699A3 (en) | 1999-09-15 |
EP0934415A2 (en) | 1999-08-11 |
JP2001500383A (en) | 2001-01-16 |
PL333304A1 (en) | 1999-11-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |