BR9712197A - Aqueous liquid pharmaceutical formulation and processes for preparing it, and for inhibiting bone resorption. - Google Patents
Aqueous liquid pharmaceutical formulation and processes for preparing it, and for inhibiting bone resorption.Info
- Publication number
- BR9712197A BR9712197A BR9712197-5A BR9712197A BR9712197A BR 9712197 A BR9712197 A BR 9712197A BR 9712197 A BR9712197 A BR 9712197A BR 9712197 A BR9712197 A BR 9712197A
- Authority
- BR
- Brazil
- Prior art keywords
- processes
- pharmaceutical formulation
- preparing
- liquid pharmaceutical
- aqueous liquid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"FORMULAçãO FARMACêUTICA LìQUIDA AQUOSA E PROCESSOS DE PREPARAçãO DA MESMA, E, DE INIBIçãO DE REABSORçãO DE OSSO". Uma formulação líquida de ácido alendrónico ou de um sal farmaceuticamente aceitável tem suficiente tampão de modo que o pH da formulação seja 4-7,5, e 15 ml da formulação sejam capazes de aumentar o pH de 50 ml de HC1 0,1 N de um até pelo menos 3 e de preferência 4."LIQUID LIQUID PHARMACEUTICAL FORMULATION AND PREPARATION PROCESSES OF THE SAME, AND, INHIBITION OF BONE REABSORPTION". A liquid formulation of alendronic acid or a pharmaceutically acceptable salt has sufficient buffer so that the pH of the formulation is 4-7.5, and 15 ml of the formulation is able to raise the pH to 50 ml of 0.1 N HCl. one to at least 3 and preferably 4.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2676596P | 1996-10-04 | 1996-10-04 | |
GBGB9700541.7A GB9700541D0 (en) | 1997-01-13 | 1997-01-13 | Liquid alendronate formulation |
US3600297P | 1997-01-22 | 1997-01-22 | |
PCT/US1997/015740 WO1998014196A1 (en) | 1996-10-04 | 1997-10-02 | Liquid alendronate formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712197A true BR9712197A (en) | 1999-08-31 |
Family
ID=27268667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712197-5A BR9712197A (en) | 1996-10-04 | 1997-10-02 | Aqueous liquid pharmaceutical formulation and processes for preparing it, and for inhibiting bone resorption. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1007054A4 (en) |
JP (1) | JP2001501222A (en) |
CN (1) | CN1238691A (en) |
AU (1) | AU723357B2 (en) |
BG (1) | BG103306A (en) |
BR (1) | BR9712197A (en) |
CA (1) | CA2267370A1 (en) |
CZ (1) | CZ116999A3 (en) |
EA (1) | EA001213B1 (en) |
EE (1) | EE03669B1 (en) |
HU (1) | HUP0000125A3 (en) |
IL (1) | IL129127A0 (en) |
IS (1) | IS5012A (en) |
NO (1) | NO991569L (en) |
NZ (1) | NZ334836A (en) |
PL (1) | PL332496A1 (en) |
SK (1) | SK42999A3 (en) |
TR (1) | TR199900730T2 (en) |
WO (1) | WO1998014196A1 (en) |
YU (1) | YU17499A (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7560490B2 (en) * | 2001-01-23 | 2009-07-14 | Gador S.A. | Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof |
US20080286359A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US20080287400A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US7645460B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of risedronate |
US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
US7473684B2 (en) | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
JP2009508834A (en) * | 2005-09-16 | 2009-03-05 | セラマイン リミテッド | Bisphosphonate formulation |
JP2010043119A (en) * | 2009-10-16 | 2010-02-25 | Gador Sa | Composition for preventing and/or treating bone metabolic disease, method of preparing the same and use thereof |
US8568747B1 (en) | 2012-10-05 | 2013-10-29 | Silvergate Pharmaceuticals, Inc. | Enalapril compositions |
US9463183B1 (en) | 2015-10-30 | 2016-10-11 | Silvergate Pharmaceuticals, Inc. | Lisinopril formulations |
US9669008B1 (en) | 2016-03-18 | 2017-06-06 | Silvergate Pharmaceuticals, Inc. | Enalapril formulations |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4206209A (en) * | 1978-11-02 | 1980-06-03 | Kracauer Paul | Sublingual aspirin tablet |
IT1201087B (en) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | PHARMACOLOGICALLY ACTIVE BIPPHOSPHONES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS |
US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
US5358941A (en) * | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
FR2703590B1 (en) * | 1993-04-05 | 1995-06-30 | Sanofi Elf | USE OF BISPHOSPHONIC ACID DERIVATIVES FOR THE PREPARATION OF MEDICINES FOR PROMOTING BONE REPAIR. |
US5510517A (en) * | 1993-08-25 | 1996-04-23 | Merck & Co., Inc. | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
US5462932A (en) * | 1994-05-17 | 1995-10-31 | Merck & Co., Inc. | Oral liquid alendronate formulations |
US5780455A (en) * | 1994-08-24 | 1998-07-14 | Merck & Co., Inc. | Intravenous alendronate formulations |
US5616571A (en) * | 1995-06-06 | 1997-04-01 | Merck & Co., Inc. | Bisphosphonates prevent bone loss associated with immunosuppressive therapy |
-
1997
- 1997-10-02 EP EP97945195A patent/EP1007054A4/en not_active Withdrawn
- 1997-10-02 WO PCT/US1997/015740 patent/WO1998014196A1/en not_active Application Discontinuation
- 1997-10-02 EA EA199900352A patent/EA001213B1/en not_active IP Right Cessation
- 1997-10-02 HU HU0000125A patent/HUP0000125A3/en unknown
- 1997-10-02 CZ CZ991169A patent/CZ116999A3/en unknown
- 1997-10-02 TR TR1999/00730T patent/TR199900730T2/en unknown
- 1997-10-02 JP JP10516541A patent/JP2001501222A/en active Pending
- 1997-10-02 CA CA002267370A patent/CA2267370A1/en not_active Abandoned
- 1997-10-02 EE EEP199900113A patent/EE03669B1/en not_active IP Right Cessation
- 1997-10-02 IL IL12912797A patent/IL129127A0/en unknown
- 1997-10-02 CN CN97180165A patent/CN1238691A/en active Pending
- 1997-10-02 BR BR9712197-5A patent/BR9712197A/en unknown
- 1997-10-02 SK SK429-99A patent/SK42999A3/en unknown
- 1997-10-02 AU AU46448/97A patent/AU723357B2/en not_active Ceased
- 1997-10-02 NZ NZ334836A patent/NZ334836A/en unknown
- 1997-10-02 PL PL97332496A patent/PL332496A1/en unknown
-
1999
- 1999-03-26 IS IS5012A patent/IS5012A/en unknown
- 1999-03-30 NO NO991569A patent/NO991569L/en not_active Application Discontinuation
- 1999-03-31 YU YU17499A patent/YU17499A/en unknown
- 1999-04-02 BG BG103306A patent/BG103306A/en unknown
Also Published As
Publication number | Publication date |
---|---|
TR199900730T2 (en) | 1999-07-21 |
YU17499A (en) | 1999-11-22 |
SK42999A3 (en) | 2000-01-18 |
EA001213B1 (en) | 2000-12-25 |
EA199900352A1 (en) | 1999-08-26 |
EE03669B1 (en) | 2002-04-15 |
CZ116999A3 (en) | 1999-09-15 |
IL129127A0 (en) | 2000-02-17 |
IS5012A (en) | 1999-03-26 |
BG103306A (en) | 2000-01-31 |
AU723357B2 (en) | 2000-08-24 |
EP1007054A4 (en) | 2000-07-19 |
WO1998014196A1 (en) | 1998-04-09 |
CA2267370A1 (en) | 1998-04-09 |
NO991569L (en) | 1999-06-04 |
PL332496A1 (en) | 1999-09-13 |
EE9900113A (en) | 1999-10-15 |
AU4644897A (en) | 1998-04-24 |
EP1007054A1 (en) | 2000-06-14 |
NZ334836A (en) | 2000-11-24 |
HUP0000125A2 (en) | 2000-06-28 |
NO991569D0 (en) | 1999-03-30 |
CN1238691A (en) | 1999-12-15 |
JP2001501222A (en) | 2001-01-30 |
HUP0000125A3 (en) | 2001-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |