BR9608804A - Processes for synthesizing (1s, 2r) indandiol to synthesize (1s) amino (2r) indanol substantially free of any bio-resolution stereoisomer to remove cis (1s, 2r) indandiol from a mixture of cis (1s, 2r) indandiol and cis (1r, 2s) indandiol and pure culture - Google Patents

Processes for synthesizing (1s, 2r) indandiol to synthesize (1s) amino (2r) indanol substantially free of any bio-resolution stereoisomer to remove cis (1s, 2r) indandiol from a mixture of cis (1s, 2r) indandiol and cis (1r, 2s) indandiol and pure culture

Info

Publication number
BR9608804A
BR9608804A BR9608804A BR9608804A BR9608804A BR 9608804 A BR9608804 A BR 9608804A BR 9608804 A BR9608804 A BR 9608804A BR 9608804 A BR9608804 A BR 9608804A BR 9608804 A BR9608804 A BR 9608804A
Authority
BR
Brazil
Prior art keywords
indandiol
cis
stereoisomer
synthesize
bio
Prior art date
Application number
BR9608804A
Other languages
Portuguese (pt)
Inventor
Neal C Connors
Francis P Gailliot
Barry C Buckland
Randolph L Greasham
Chris H Senanayake
Chanyong Lee
Rober C Olewinski Jr
F Edward Roberts
Paul J Reider
Michel M Chartrain
Thomas R Verhoeven
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602938.4A external-priority patent/GB9602938D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BR9608804A publication Critical patent/BR9608804A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
BR9608804A 1995-06-20 1996-06-14 Processes for synthesizing (1s, 2r) indandiol to synthesize (1s) amino (2r) indanol substantially free of any bio-resolution stereoisomer to remove cis (1s, 2r) indandiol from a mixture of cis (1s, 2r) indandiol and cis (1r, 2s) indandiol and pure culture BR9608804A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36095P 1995-06-20 1995-06-20
GBGB9602938.4A GB9602938D0 (en) 1996-02-13 1996-02-13 Conversion of indene
PCT/US1996/010445 WO1997000966A1 (en) 1995-06-20 1996-06-14 Conversion of indene to (1s)-amino-(2r)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps

Publications (1)

Publication Number Publication Date
BR9608804A true BR9608804A (en) 1999-02-17

Family

ID=26308684

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9608804A BR9608804A (en) 1995-06-20 1996-06-14 Processes for synthesizing (1s, 2r) indandiol to synthesize (1s) amino (2r) indanol substantially free of any bio-resolution stereoisomer to remove cis (1s, 2r) indandiol from a mixture of cis (1s, 2r) indandiol and cis (1r, 2s) indandiol and pure culture

Country Status (5)

Country Link
CN (1) CN1194006A (en)
AR (1) AR002536A1 (en)
AU (1) AU6180096A (en)
BR (1) BR9608804A (en)
WO (1) WO1997000966A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420067D0 (en) * 1994-10-05 1994-11-16 Zeneca Ltd Process
US5858737A (en) * 1995-06-20 1999-01-12 Merck & Co., Inc. Conversion of indene to (1S)-amino-(2R)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
US5824540A (en) * 1995-06-20 1998-10-20 Merck & Co., Inc. Pseudomonas putida strain with dioxygenase activity
WO1997025436A1 (en) * 1996-01-12 1997-07-17 Nippon Steel Chemical Co., Ltd. Processes for producing indane derivatives
NL1005832C2 (en) * 1997-04-17 1998-10-20 Dsm Nv Optically active cis-(1S,2R)-amino-indanol preparation
GB2336841A (en) 1998-04-28 1999-11-03 Merck & Co Inc Preparation of cis-(is,2r)-indanediol by the microbial reduction of 1,2-indanedione
WO2000009659A1 (en) * 1998-08-13 2000-02-24 Lonza Ag Method for producing indane derivatives
NL1010354C2 (en) * 1998-10-20 2000-04-25 Dsm Biotech Gmbh Preparation of amino alcohols.
NO2280721T3 (en) * 2008-04-17 2018-04-14

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols
US5420353A (en) * 1994-03-11 1995-05-30 Merck & Co., Inc. Regiospecific process to make cis-1-amino-2-alkanol from epoxide
GB9420067D0 (en) * 1994-10-05 1994-11-16 Zeneca Ltd Process

Also Published As

Publication number Publication date
AR002536A1 (en) 1998-03-25
CN1194006A (en) 1998-09-23
WO1997000966A1 (en) 1997-01-09
AU6180096A (en) 1997-01-22

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Legal Events

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EG Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal