Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm SpafiledCriticalChiesi Farm Spa
Priority to BR132021008669ApriorityCriticalpatent/BR132021008669E2/en
Publication of BR132021008669E2publicationCriticalpatent/BR132021008669E2/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PROCESSOS PARA PREPARAR UM PDE4 INHIBITOR. O presente certificado de adição se refere a um processo e intermediários para a preparação de compostos dotados de atividade inibidora de fosfodiesterase (PDE4) e que apresentam a fórmula (1). O presente certificado de adição também se refere ao processo de isolamento por meio de cristalização do composto (1) e de seu uso para a preparação de composições farmacêuticas para inalação em combinação com veículos ou carreadores adequados. O presente certificado de adição também se refere a solvatos e formas cristalinas de um composto da fórmula (I). O produto sintetizado é adequado para uso em aplicações farmacêuticas, por exemplo, no tratamento de doenças respiratórias.PROCESSES FOR PREPARING A PDE4 INHIBITOR. The present certificate of addition refers to a process and intermediates for the preparation of compounds endowed with phosphodiesterase (PDE4) inhibitory activity and which have the formula (1). The present certificate of addition also relates to the process of isolation by means of crystallization of compound (1) and its use for the preparation of pharmaceutical compositions for inhalation in combination with suitable vehicles or carriers. The present certificate of addition also relates to solvates and crystalline forms of a compound of formula (I). The synthesized product is suitable for use in pharmaceutical applications, for example in the treatment of respiratory diseases.
BR132021008669A2021-05-042021-05-04
PROCESSES TO PREPARE A PDE4 INHIBITOR
BR132021008669E2
(en)
thienopyridone derivatives as amp-activated protein kinase (ampk) activators, their uses, their preparation process and their intermediates, and drugs.
PROCESS FOR THE PREPARATION OF ACID 6- (3-CHLORO-2-FLUORBENCIL) -1 - [(S) -1-HYDROXIMETHYL-2-METHYLPROPIL] -7-METOXI-4-OXO-1, 4-DIHYDROQUINOLON-3- CARBOXILICO AS HIV INTEGRASA INHIBITORS AND SYNTHESIS INTERMEDIARIES OF THE SAME AND COMPOSITIONS THAT UNDERSTAND IT.
COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT, HYDRATE, SOLVATE, ISOFORM, TAUTOMER, OPTICAL ISOMER OR A COMBINATION THEREOF, PHARMACEUTICAL COMPOSITION, METHOD FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSCHIATRIC DISORDERS, USE OF A COMPOUND, AND, PROCESS FOR THE PREPARATION OF A COMPOUND
pyrrol derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenative disorders such as alzheimer's disease and parkinson's disease
compound, pharmaceutical composition, use of a compound for the preparation of a medicament for the treatment of a condition resulting from an abnormality of nitric oxide production, use of a compound for the preparation of a medicament for the treatment of pain in an individual with need thereof and use of a compound for the preparation of a medicament for the treatment of inhibition of dimerization of inos
"Antibacterial cyclopenta [c] pyrrol substituted 3,4-dihydro-1h- [1,8] naphthyridinones, pharmaceutical composition comprising said compounds, processes for their preparation and use".