BR112023021235A2 - CO-CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR - Google Patents

CO-CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR

Info

Publication number
BR112023021235A2
BR112023021235A2 BR112023021235A BR112023021235A BR112023021235A2 BR 112023021235 A2 BR112023021235 A2 BR 112023021235A2 BR 112023021235 A BR112023021235 A BR 112023021235A BR 112023021235 A BR112023021235 A BR 112023021235A BR 112023021235 A2 BR112023021235 A2 BR 112023021235A2
Authority
BR
Brazil
Prior art keywords
tyrosine kinase
kinase inhibitor
bruton
crystalline forms
btk
Prior art date
Application number
BR112023021235A
Other languages
Portuguese (pt)
Inventor
Andrew Coates David
Raquel Hilden Lori
Original Assignee
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loxo Oncology Inc filed Critical Loxo Oncology Inc
Publication of BR112023021235A2 publication Critical patent/BR112023021235A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/14—Adipic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

formas cocristalinas de um inibidor da tirosina quinase de bruton, composições farmacêuticas que as compreendem e usos das mesmas. a presente invenção refere-se aqui, neste requerimento de patente, a formas cocristalinas incluindo btk-i úteis no tratamento e na prevenção de doenças as quais podem ser tratadas com um inibidor da btk, incluindo doenças e distúrbios associados com btk, caracterizações e métodos de produção destas formas cocristalinas.cocrystalline forms of a Bruton tyrosine kinase inhibitor, pharmaceutical compositions comprising them and uses thereof. The present invention relates herein, in this patent application, to cocrystalline forms including btk-i useful in the treatment and prevention of diseases which can be treated with a btk inhibitor, including diseases and disorders associated with btk, characterizations and methods production of these cocrystalline forms.

BR112023021235A 2021-05-14 2022-05-11 CO-CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR BR112023021235A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163188747P 2021-05-14 2021-05-14
PCT/US2022/028663 WO2022240920A1 (en) 2021-05-14 2022-05-11 Cocrystalline forms of a bruton's tyrosine kinase inhibitor

Publications (1)

Publication Number Publication Date
BR112023021235A2 true BR112023021235A2 (en) 2023-12-12

Family

ID=82019727

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023021235A BR112023021235A2 (en) 2021-05-14 2022-05-11 CO-CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR

Country Status (8)

Country Link
EP (1) EP4337196A1 (en)
KR (1) KR20230171449A (en)
CN (1) CN117320712A (en)
AU (1) AU2022274771A1 (en)
BR (1) BR112023021235A2 (en)
CA (1) CA3217452A1 (en)
IL (1) IL308011A (en)
WO (1) WO2022240920A1 (en)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9138436B2 (en) 2011-07-13 2015-09-22 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
EP3082809B1 (en) 2013-12-20 2021-01-20 Merck Sharp & Dohme Corp. Btk inhibitors
SG11201606858RA (en) 2014-02-21 2016-09-29 Principia Biopharma Inc Salts and solid form of a btk inhibitor
MX2018007267A (en) 2015-12-16 2018-11-09 Loxo Oncology Inc Compounds useful as kinase inhibitors.
KR20210034623A (en) 2018-07-20 2021-03-30 메르크 파텐트 게엠베하 Substituted amino-pyrimidine compounds for use in methods for the treatment and prevention of multiple sclerosis
KR102545594B1 (en) 2018-07-31 2023-06-21 록쏘 온콜로지, 인코포레이티드 (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl Spray-dried dispersions and formulations of )-1H-pyrazole-4-carboxamide
IL296990A (en) 2020-04-03 2022-12-01 Genentech Inc Methods of treating relapsing multiple sclerosis using an inhibitor of bruton's tyrosine kinase

Also Published As

Publication number Publication date
IL308011A (en) 2023-12-01
AU2022274771A1 (en) 2023-11-16
EP4337196A1 (en) 2024-03-20
CN117320712A (en) 2023-12-29
CA3217452A1 (en) 2022-11-17
WO2022240920A1 (en) 2022-11-17
KR20230171449A (en) 2023-12-20

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