BR112023018826A2 - Inibidores de c5ar1 para tratamento de reações de hipersensibilidade a taxanos - Google Patents
Inibidores de c5ar1 para tratamento de reações de hipersensibilidade a taxanosInfo
- Publication number
- BR112023018826A2 BR112023018826A2 BR112023018826A BR112023018826A BR112023018826A2 BR 112023018826 A2 BR112023018826 A2 BR 112023018826A2 BR 112023018826 A BR112023018826 A BR 112023018826A BR 112023018826 A BR112023018826 A BR 112023018826A BR 112023018826 A2 BR112023018826 A2 BR 112023018826A2
- Authority
- BR
- Brazil
- Prior art keywords
- c5ar1
- treatment
- taxanes
- inhibitors
- hypersensitivity reactions
- Prior art date
Links
- 206010020751 Hypersensitivity Diseases 0.000 title abstract 3
- 229940123237 Taxane Drugs 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 102100032957 C5a anaphylatoxin chemotactic receptor 1 Human genes 0.000 title 1
- 101000867983 Homo sapiens C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 title 1
- 208000026935 allergic disease Diseases 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 230000009610 hypersensitivity Effects 0.000 title 1
- 101150009981 C5AR1 gene Proteins 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
inibidores de c5ar1 para tratamento de reações de hipersensibilidade a taxanos. a presente invenção refere-se ao uso de um inibidor de c5ar1 para a prevenção ou tratamento de uma reação de hipersensibilidade (rhs) a um taxano em um indivíduo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21163292.2A EP4059497A1 (en) | 2021-03-17 | 2021-03-17 | C5ar1 inhibitors for treating hypersensitivity reactions to taxanes |
| EP21217382 | 2021-12-23 | ||
| PCT/EP2022/057007 WO2022195017A1 (en) | 2021-03-17 | 2022-03-17 | C5ar1 inhibitors for treating hypersensitivity reactions to taxanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023018826A2 true BR112023018826A2 (pt) | 2024-03-12 |
Family
ID=81307212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023018826A BR112023018826A2 (pt) | 2021-03-17 | 2022-03-17 | Inibidores de c5ar1 para tratamento de reações de hipersensibilidade a taxanos |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4308114A1 (pt) |
| JP (1) | JP2024512472A (pt) |
| BR (1) | BR112023018826A2 (pt) |
| CA (1) | CA3212816A1 (pt) |
| IL (1) | IL305727A (pt) |
| WO (1) | WO2022195017A1 (pt) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ9904244A3 (cs) * | 1997-05-27 | 2001-10-17 | Baker Norton Pharmaceuticals, Inc. | Pouľití taxanů, jejich derivátů, analogů nebo předléků pro přípravu farmaceutického prostředku pro perorální podávání |
| JP2003512443A (ja) * | 1999-10-27 | 2003-04-02 | ベーカー ノートン ファーマシューティカルズ インコーポレイテッド | タキサンをヒト患者に経口投与するための方法及び組成物 |
| LT1951663T (lt) | 2005-11-24 | 2016-11-10 | Dompé Farmaceutici S.P.A. | (r)-arilalkilamino dariniai ir juos turinčios farmacinės kompozicijos |
| EP3498269A1 (en) * | 2017-12-12 | 2019-06-19 | Dompé farmaceutici S.p.A. | C5ar inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain |
-
2022
- 2022-03-17 CA CA3212816A patent/CA3212816A1/en active Pending
- 2022-03-17 IL IL305727A patent/IL305727A/en unknown
- 2022-03-17 EP EP22716203.9A patent/EP4308114A1/en active Pending
- 2022-03-17 WO PCT/EP2022/057007 patent/WO2022195017A1/en active Application Filing
- 2022-03-17 BR BR112023018826A patent/BR112023018826A2/pt unknown
- 2022-03-17 JP JP2023556979A patent/JP2024512472A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024512472A (ja) | 2024-03-19 |
| CA3212816A1 (en) | 2022-09-22 |
| WO2022195017A1 (en) | 2022-09-22 |
| EP4308114A1 (en) | 2024-01-24 |
| IL305727A (en) | 2023-11-01 |
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