BR112023013898A2 - Heterodímero compreendendo dois polipeptídeos selecionados a partir do grupo que consiste em proteína reguladora de sinal alfa, morte programada 1, imunorreceptor de células t com domínios da imunoglobulina e do motivo de inibição baseado em tirosina de imunorreceptor, receptor de leucócitos tipo imunoglobulina, sub família b, membro 2, e lectina 10 semelhante à imunoglobulina de ligação ao ácido siálico, composição compreendendo o heterodímero, construção ou sistema de ácido nucleico, célula hospedeira, e, métodos para produzir um heterodímero, para tratar uma doença e para ativar células imunes - Google Patents
Heterodímero compreendendo dois polipeptídeos selecionados a partir do grupo que consiste em proteína reguladora de sinal alfa, morte programada 1, imunorreceptor de células t com domínios da imunoglobulina e do motivo de inibição baseado em tirosina de imunorreceptor, receptor de leucócitos tipo imunoglobulina, sub família b, membro 2, e lectina 10 semelhante à imunoglobulina de ligação ao ácido siálico, composição compreendendo o heterodímero, construção ou sistema de ácido nucleico, célula hospedeira, e, métodos para produzir um heterodímero, para tratar uma doença e para ativar células imunesInfo
- Publication number
- BR112023013898A2 BR112023013898A2 BR112023013898A BR112023013898A BR112023013898A2 BR 112023013898 A2 BR112023013898 A2 BR 112023013898A2 BR 112023013898 A BR112023013898 A BR 112023013898A BR 112023013898 A BR112023013898 A BR 112023013898A BR 112023013898 A2 BR112023013898 A2 BR 112023013898A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterodimer
- immunoglobulin
- cell
- nucleic acid
- methods
- Prior art date
Links
- 239000000833 heterodimer Substances 0.000 title abstract 9
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 4
- 102000018358 immunoglobulin Human genes 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 101710198418 Lectin 10 Proteins 0.000 title abstract 2
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 title abstract 2
- 230000003213 activating effect Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 210000002865 immune cell Anatomy 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 210000000265 leukocyte Anatomy 0.000 title abstract 2
- 108020003175 receptors Proteins 0.000 title abstract 2
- 238000010276 construction Methods 0.000 title 1
- 102000034356 gene-regulatory proteins Human genes 0.000 title 1
- 108091006104 gene-regulatory proteins Proteins 0.000 title 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 2
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 101100369641 Mus musculus Tigit gene Proteins 0.000 abstract 1
- 101150036449 SIRPA gene Proteins 0.000 abstract 1
- 101710143293 Sialic acid-binding Ig-like lectin 10 Proteins 0.000 abstract 1
- 102100027164 Sialic acid-binding Ig-like lectin 10 Human genes 0.000 abstract 1
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163136687P | 2021-01-13 | 2021-01-13 | |
| US202163139331P | 2021-01-20 | 2021-01-20 | |
| PCT/IL2022/050055 WO2022153307A1 (en) | 2021-01-13 | 2022-01-13 | Type i membrane proteins heterodimers and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023013898A2 true BR112023013898A2 (pt) | 2023-10-31 |
Family
ID=82447997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023013898A BR112023013898A2 (pt) | 2021-01-13 | 2022-01-13 | Heterodímero compreendendo dois polipeptídeos selecionados a partir do grupo que consiste em proteína reguladora de sinal alfa, morte programada 1, imunorreceptor de células t com domínios da imunoglobulina e do motivo de inibição baseado em tirosina de imunorreceptor, receptor de leucócitos tipo imunoglobulina, sub família b, membro 2, e lectina 10 semelhante à imunoglobulina de ligação ao ácido siálico, composição compreendendo o heterodímero, construção ou sistema de ácido nucleico, célula hospedeira, e, métodos para produzir um heterodímero, para tratar uma doença e para ativar células imunes |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240076346A1 (https=) |
| EP (1) | EP4277923A4 (https=) |
| JP (1) | JP2024503685A (https=) |
| KR (1) | KR20230169933A (https=) |
| AU (1) | AU2022208466A1 (https=) |
| BR (1) | BR112023013898A2 (https=) |
| CA (1) | CA3204707A1 (https=) |
| IL (1) | IL304381A (https=) |
| MX (1) | MX2023008351A (https=) |
| WO (1) | WO2022153307A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2769769C2 (ru) | 2017-01-05 | 2022-04-05 | Кахр Медикал Лтд. | СЛИТЫЙ БЕЛОК SIRPα-4-1BBL И СПОСОБЫ ЕГО ПРИМЕНЕНИЯ |
| CN110536693B (zh) | 2017-01-05 | 2023-12-22 | 卡尔医学有限公司 | Pd1-41bbl融合蛋白及使用其的方法 |
| US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
| EP3820887A4 (en) | 2018-07-11 | 2022-04-20 | KAHR Medical Ltd. | Pd1-4-1bbl variant fusion protein and methods of use thereof |
| KR102945860B1 (ko) | 2018-07-11 | 2026-03-31 | 카 메디컬 리미티드 | SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법 |
| CN111454369A (zh) * | 2020-04-10 | 2020-07-28 | 润方(长春)生物科技有限公司 | 一种用于制备异二聚物蛋白质的方法 |
| US20250051410A1 (en) * | 2021-12-23 | 2025-02-13 | Kahr Medical Ltd. | Lilrb polypeptides and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| WO2014164519A1 (en) * | 2013-03-12 | 2014-10-09 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for inhibiting the effects of amyloid beta oligomers |
| WO2016023001A1 (en) * | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Multispecific high affinity pd-1 agents and methods of use |
| CN113831417B (zh) * | 2017-05-08 | 2024-10-01 | 上海津曼特生物科技有限公司 | 双特异性重组蛋白及其应用 |
| CN107857819A (zh) * | 2017-07-03 | 2018-03-30 | 江苏西迪尔生物技术有限公司 | 多功能融合蛋白及其应用 |
| EP3908664A4 (en) * | 2019-01-07 | 2023-01-25 | Thomas Jefferson University | MULTIFUNCTIONAL FUSION PROTEINS AND THEIR USES |
| EP3947460A4 (en) * | 2019-03-26 | 2023-05-10 | Forty Seven, Inc. | MULTISPECIFIC AGENTS FOR TREATMENT OF CANCER |
| TWI760751B (zh) * | 2019-05-29 | 2022-04-11 | 美商美國禮來大藥廠 | Tigit及pd-1/tigit-結合分子 |
| CN110128550B (zh) * | 2019-05-30 | 2023-01-13 | 南京惟亚德生物医药有限公司 | 一种新型的同时阻断免疫检查点pd-l1和tigit的复制型溶瘤腺病毒和应用 |
| US20220267409A1 (en) * | 2019-07-11 | 2022-08-25 | Kahr Medical Ltd. | Heterodimers and methods of use thereof |
-
2021
- 2021-01-13 US US18/272,154 patent/US20240076346A1/en active Pending
-
2022
- 2022-01-13 AU AU2022208466A patent/AU2022208466A1/en active Pending
- 2022-01-13 KR KR1020237027209A patent/KR20230169933A/ko active Pending
- 2022-01-13 WO PCT/IL2022/050055 patent/WO2022153307A1/en not_active Ceased
- 2022-01-13 EP EP22739265.1A patent/EP4277923A4/en active Pending
- 2022-01-13 MX MX2023008351A patent/MX2023008351A/es unknown
- 2022-01-13 BR BR112023013898A patent/BR112023013898A2/pt unknown
- 2022-01-13 CA CA3204707A patent/CA3204707A1/en active Pending
- 2022-01-13 JP JP2023542757A patent/JP2024503685A/ja active Pending
-
2023
- 2023-07-10 IL IL304381A patent/IL304381A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL304381A (en) | 2023-09-01 |
| MX2023008351A (es) | 2023-10-10 |
| KR20230169933A (ko) | 2023-12-18 |
| WO2022153307A1 (en) | 2022-07-21 |
| AU2022208466A1 (en) | 2023-08-17 |
| JP2024503685A (ja) | 2024-01-26 |
| AU2022208466A9 (en) | 2024-07-11 |
| CA3204707A1 (en) | 2022-07-21 |
| EP4277923A1 (en) | 2023-11-22 |
| US20240076346A1 (en) | 2024-03-07 |
| EP4277923A4 (en) | 2025-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112023013898A2 (pt) | Heterodímero compreendendo dois polipeptídeos selecionados a partir do grupo que consiste em proteína reguladora de sinal alfa, morte programada 1, imunorreceptor de células t com domínios da imunoglobulina e do motivo de inibição baseado em tirosina de imunorreceptor, receptor de leucócitos tipo imunoglobulina, sub família b, membro 2, e lectina 10 semelhante à imunoglobulina de ligação ao ácido siálico, composição compreendendo o heterodímero, construção ou sistema de ácido nucleico, célula hospedeira, e, métodos para produzir um heterodímero, para tratar uma doença e para ativar células imunes | |
| BR112022000319A2 (pt) | Heterodímeros e métodos de uso dos mesmos | |
| Inanobe et al. | Gβγ directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1 | |
| CN111836638B (zh) | 针对突变的ras的hla i类限制性t细胞受体 | |
| Lanier | Natural killer cell receptor signaling | |
| Bryant et al. | Mice, men and the relatives: cross-species studies underpin innate immunity | |
| Hartleben et al. | Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity | |
| Gounari et al. | Amino‐terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. | |
| Sellers et al. | Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping" leucine zippers" | |
| McCormick et al. | SV40 T antigen binds specifically to a cellular 53 K protein in vitro | |
| Li et al. | Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells | |
| Xu et al. | Two novel C-type lectins with a low-density lipoprotein receptor class A domain have antiviral function in the shrimp Marsupenaeus japonicus | |
| Mallya et al. | Characterization of the five novel Ly‐6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands | |
| Latchman | Transcription factors: a practical approach | |
| Sever et al. | Expression of tapasin in rainbow trout tissues and cell lines and up regulation in a monocyte/macrophage cell line (RTS11) by a viral mimic and viral infection | |
| Moon et al. | Tissue-specific expression of distinct spectrin and ankyrin transcripts in erythroid and nonerythroid cells. | |
| KR20220143875A (ko) | G12v 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 | |
| Ying et al. | Cloning and characterization of rat Luman/CREB3, a transcription factor highly expressed in nervous system tissue | |
| Shimada et al. | Regulation of TFF3 expression by homeodomain protein CDX2 | |
| Mißbach et al. | Alternative splicing after gene duplication drives CEACAM1-paralog diversification in the horse | |
| McCarthy et al. | Activin-A binds to a heterotrimeric receptor complex on the vascular endothelial cell surface. Evidence for a type 3 activin receptor. | |
| Rahman et al. | Interaction of human TNF and β2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L | |
| RePass et al. | Molecular cloning, expression, and characterization of UDP N-acetyl-α-d-galactosamine: Polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum | |
| Moshitzky et al. | Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells | |
| Huang et al. | Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus |