BR112023003452A2 - SYNTHESIS OF PYRROL ACID DERIVATIVES - Google Patents
SYNTHESIS OF PYRROL ACID DERIVATIVESInfo
- Publication number
- BR112023003452A2 BR112023003452A2 BR112023003452A BR112023003452A BR112023003452A2 BR 112023003452 A2 BR112023003452 A2 BR 112023003452A2 BR 112023003452 A BR112023003452 A BR 112023003452A BR 112023003452 A BR112023003452 A BR 112023003452A BR 112023003452 A2 BR112023003452 A2 BR 112023003452A2
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- acid derivatives
- pyrrol
- combination
- antibacterial agents
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 2
- 239000002253 acid Substances 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- 229940041011 carbapenems Drugs 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 102000020235 metallo-beta-lactamase Human genes 0.000 abstract 1
- 108060004734 metallo-beta-lactamase Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pyrrole Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Esta invenção se refere à síntese de compostos que podem ser usados para tratar infecções bacterianas em combinação com outros agentes antibacterianos, e mais especificamente em combinação com uma classe de agentes antibacterianos conhecidos como carbapenemas. Os compostos resultantes dos novos métodos da presente invenção são inibidores enzimáticos e mais particularmente são inibidores da metalo-ß-lactamase.This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the new methods of the present invention are enzymatic inhibitors and more particularly are metallo-ß-lactamase inhibitors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2015885.3A GB202015885D0 (en) | 2020-10-07 | 2020-10-07 | Synthesis of pyrrole acid derivatives |
| PCT/GB2021/052580 WO2022074385A1 (en) | 2020-10-07 | 2021-10-06 | Synthesis of pyrrole acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023003452A2 true BR112023003452A2 (en) | 2023-05-02 |
Family
ID=73223783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023003452A BR112023003452A2 (en) | 2020-10-07 | 2021-10-06 | SYNTHESIS OF PYRROL ACID DERIVATIVES |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230286915A1 (en) |
| EP (1) | EP4225734A1 (en) |
| JP (1) | JP2023544801A (en) |
| KR (1) | KR20230083278A (en) |
| CN (1) | CN116209652A (en) |
| AU (1) | AU2021357874A1 (en) |
| BR (1) | BR112023003452A2 (en) |
| CA (1) | CA3190017A1 (en) |
| GB (1) | GB202015885D0 (en) |
| IL (1) | IL301583A (en) |
| MX (1) | MX2023004012A (en) |
| WO (1) | WO2022074385A1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11459296B2 (en) | 2018-05-16 | 2022-10-04 | Infex Therapeutics Limited | Antibacterial compounds |
| GB201916915D0 (en) * | 2019-11-20 | 2020-01-01 | Amr Centre Ltd | Compounds |
-
2020
- 2020-10-07 GB GBGB2015885.3A patent/GB202015885D0/en not_active Ceased
-
2021
- 2021-10-06 CN CN202180064068.4A patent/CN116209652A/en active Pending
- 2021-10-06 EP EP21794918.9A patent/EP4225734A1/en active Pending
- 2021-10-06 JP JP2023521304A patent/JP2023544801A/en active Pending
- 2021-10-06 WO PCT/GB2021/052580 patent/WO2022074385A1/en active Application Filing
- 2021-10-06 CA CA3190017A patent/CA3190017A1/en active Pending
- 2021-10-06 BR BR112023003452A patent/BR112023003452A2/en unknown
- 2021-10-06 IL IL301583A patent/IL301583A/en unknown
- 2021-10-06 AU AU2021357874A patent/AU2021357874A1/en active Pending
- 2021-10-06 US US18/246,777 patent/US20230286915A1/en active Pending
- 2021-10-06 MX MX2023004012A patent/MX2023004012A/en unknown
- 2021-10-06 KR KR1020237010864A patent/KR20230083278A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4225734A1 (en) | 2023-08-16 |
| AU2021357874A1 (en) | 2023-03-23 |
| IL301583A (en) | 2023-05-01 |
| CN116209652A (en) | 2023-06-02 |
| US20230286915A1 (en) | 2023-09-14 |
| GB202015885D0 (en) | 2020-11-18 |
| JP2023544801A (en) | 2023-10-25 |
| CA3190017A1 (en) | 2022-04-14 |
| KR20230083278A (en) | 2023-06-09 |
| MX2023004012A (en) | 2023-04-26 |
| WO2022074385A1 (en) | 2022-04-14 |
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