BR112023001330A2 - N'-(2-CHLORO-6-METHYLBENZOYL)-4-METHYL-3-[2-(3-QUINOLYL)ETHYNYL]-BENZOHYDRAZIDE FOR TREATMENT OF ALZHEIMER'S DISEASE - Google Patents
N'-(2-CHLORO-6-METHYLBENZOYL)-4-METHYL-3-[2-(3-QUINOLYL)ETHYNYL]-BENZOHYDRAZIDE FOR TREATMENT OF ALZHEIMER'S DISEASEInfo
- Publication number
- BR112023001330A2 BR112023001330A2 BR112023001330A BR112023001330A BR112023001330A2 BR 112023001330 A2 BR112023001330 A2 BR 112023001330A2 BR 112023001330 A BR112023001330 A BR 112023001330A BR 112023001330 A BR112023001330 A BR 112023001330A BR 112023001330 A2 BR112023001330 A2 BR 112023001330A2
- Authority
- BR
- Brazil
- Prior art keywords
- benzohydrazide
- methylbenzoyl
- quinolyl
- ethynyl
- chloro
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
N ¢-(2-CLORO-6-METILBENZOIL)-4-METIL-3-[2-(3-QUINOLIL)ETINIL]- BENZOHIDRAZIDA PARA TRATAMENTO DA DOENÇA DE ALZHEIMER. A presente invenção fornece um método para prevenir ou tratar a doença de Alzheimer e sintomas da mesma compreendendo a administração a um indivíduo em necessidade de uma quantidade terapeuticamente eficaz de N'-(2-cloro-6-metilbenzoil)-4-metil-3-[2-(3-quinolil)etinil]-benzohidrazida ou sais farmaceuticamente aceitáveis do mesmo, em que a prevenção e/ou tratamento da referida doença e sintomas da mesma é alcançado pela inibição de beta-amiloide (Aß) agregação de placa, hiperfosforilação de tau, c-Abl quinase ou uma combinação destes. Também é divulgado o uso de uma quantidade terapeuticamente eficaz de N'-(2-cloro-6-metilbenzoil)-4-metil-3-[2-(3-quinolil)etinil]-benzohidrazida ou sais farmaceuticamente aceitáveis do mesmo para inibir a agregação de placa beta-amiloide (Aß), hiperfosforilação de tau, c-Abl quinase ou uma combinação destes.N ¢-(2-CHLORO-6-METHYLBENZOYL)-4-METHYL-3-[2-(3-QUINOLYL)ETHYNYL]-BENZOHYDRAZIDE FOR TREATMENT OF ALZHEIMER'S DISEASE. The present invention provides a method of preventing or treating Alzheimer's disease and symptoms thereof comprising administering to a subject in need of it a therapeutically effective amount of N'-(2-chloro-6-methylbenzoyl)-4-methyl-3 -[2-(3-quinolyl)ethynyl]-benzohydrazide or pharmaceutically acceptable salts thereof, wherein the prevention and/or treatment of said disease and symptoms thereof is achieved by inhibiting beta-amyloid (Aß) plaque aggregation, hyperphosphorylation of tau, c-Abl kinase or a combination thereof. Also disclosed is the use of a therapeutically effective amount of N'-(2-chloro-6-methylbenzoyl)-4-methyl-3-[2-(3-quinolyl)ethynyl]-benzohydrazide or pharmaceutically acceptable salts thereof to inhibit beta-amyloid (Aß) plaque aggregation, tau hyperphosphorylation, c-Abl kinase, or a combination thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN202021032951 | 2020-07-31 | ||
PCT/IB2021/056986 WO2022024072A1 (en) | 2020-07-31 | 2021-07-30 | N'-(2-chloro-6-methylbenzoyl)-4-methyl-3-[2-(3-quinolyl) ethynyl]-benzohydrazide for treatment of alzheimer's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023001330A2 true BR112023001330A2 (en) | 2023-02-14 |
Family
ID=77265130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023001330A BR112023001330A2 (en) | 2020-07-31 | 2021-07-30 | N'-(2-CHLORO-6-METHYLBENZOYL)-4-METHYL-3-[2-(3-QUINOLYL)ETHYNYL]-BENZOHYDRAZIDE FOR TREATMENT OF ALZHEIMER'S DISEASE |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230301982A1 (en) |
EP (1) | EP4188351A1 (en) |
JP (1) | JP2023536440A (en) |
KR (1) | KR20230047140A (en) |
CN (1) | CN116194098A (en) |
AU (1) | AU2021317186A1 (en) |
BR (1) | BR112023001330A2 (en) |
CA (1) | CA3185939A1 (en) |
CL (1) | CL2023000270A1 (en) |
IL (1) | IL300044A (en) |
MX (1) | MX2023001358A (en) |
WO (1) | WO2022024072A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023214314A1 (en) | 2022-05-02 | 2023-11-09 | Sun Pharma Advanced Research Company Limited | Vodobatinib for reducing progression of parkinson's disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101892574B1 (en) | 2011-01-21 | 2018-08-28 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | Diarylacetylene hydrazide containing tyrosine kinase inhibitors |
MY193754A (en) | 2016-06-02 | 2022-10-27 | Sun Pharma Advanced Res Co Ltd | Treatment for parkinson's disease |
CA3056348A1 (en) * | 2017-03-15 | 2018-09-20 | Sun Pharma Advanced Research Company Limited | Novel amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide |
-
2021
- 2021-07-30 US US18/018,438 patent/US20230301982A1/en active Pending
- 2021-07-30 WO PCT/IB2021/056986 patent/WO2022024072A1/en active Application Filing
- 2021-07-30 MX MX2023001358A patent/MX2023001358A/en unknown
- 2021-07-30 BR BR112023001330A patent/BR112023001330A2/en unknown
- 2021-07-30 EP EP21752214.3A patent/EP4188351A1/en active Pending
- 2021-07-30 CA CA3185939A patent/CA3185939A1/en active Pending
- 2021-07-30 JP JP2023505420A patent/JP2023536440A/en active Pending
- 2021-07-30 KR KR1020237006846A patent/KR20230047140A/en unknown
- 2021-07-30 CN CN202180061409.2A patent/CN116194098A/en active Pending
- 2021-07-30 AU AU2021317186A patent/AU2021317186A1/en active Pending
- 2021-07-30 IL IL300044A patent/IL300044A/en unknown
-
2023
- 2023-01-27 CL CL2023000270A patent/CL2023000270A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20230047140A (en) | 2023-04-06 |
JP2023536440A (en) | 2023-08-25 |
CN116194098A (en) | 2023-05-30 |
WO2022024072A1 (en) | 2022-02-03 |
EP4188351A1 (en) | 2023-06-07 |
MX2023001358A (en) | 2023-02-27 |
AU2021317186A1 (en) | 2023-03-16 |
CL2023000270A1 (en) | 2023-09-29 |
CA3185939A1 (en) | 2022-02-03 |
IL300044A (en) | 2023-03-01 |
US20230301982A1 (en) | 2023-09-28 |
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