BR112022026283A2 - ACID SPHINGOMYELINASE INHIBITORS TO PREVENT AND TREAT COVID-19 DISEASE - Google Patents

ACID SPHINGOMYELINASE INHIBITORS TO PREVENT AND TREAT COVID-19 DISEASE

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Publication number
BR112022026283A2
BR112022026283A2 BR112022026283A BR112022026283A BR112022026283A2 BR 112022026283 A2 BR112022026283 A2 BR 112022026283A2 BR 112022026283 A BR112022026283 A BR 112022026283A BR 112022026283 A BR112022026283 A BR 112022026283A BR 112022026283 A2 BR112022026283 A2 BR 112022026283A2
Authority
BR
Brazil
Prior art keywords
acid sphingomyelinase
disease
prevent
sphingomyelinase inhibitors
inhibitors
Prior art date
Application number
BR112022026283A
Other languages
Portuguese (pt)
Inventor
Hoertel Nicolas
Limosin Frédéric
Lucia Sanchez Rico Marina
Abellán Miriam
De La Muela Pedro
Gulbins Erich
Kornhuber Johannes
Carpinteiro Alexander
Original Assignee
Hopitaux Paris Assist Publique
Univ Paris Cite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20305698.1A external-priority patent/EP3928775A1/en
Priority claimed from EP20306117.1A external-priority patent/EP3973961A1/en
Priority claimed from US17/146,013 external-priority patent/US20220347127A1/en
Application filed by Hopitaux Paris Assist Publique, Univ Paris Cite filed Critical Hopitaux Paris Assist Publique
Publication of BR112022026283A2 publication Critical patent/BR112022026283A2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Abstract

INIBIDORES DE ESFINGOMIELINASE ÁCIDA PARA PREVENIR E TRATAR A DOENÇA COVID-19. A presente invenção está relacionada aos usos preventivos e terapêuticos de inibidores de esfingomielinase ácida (FIASMAs), como medicações psicotrópicas e compostos não psicotrópicos tendo atividade de FIASMA, para diminuir o risco de morte e/ou intubação em pacientes sofrendo de uma infecção viral causada por pelo menos um betacoronavírus, em particular pelo SARS-CoV-2 (Coronavírus da Síndrome Respiratória Aguda Grave 2).ACID SPHINGOMYELINASE INHIBITORS TO PREVENT AND TREAT COVID-19 DISEASE. The present invention relates to preventive and therapeutic uses of acid sphingomyelinase inhibitors (FIASMAs), as psychotropic medications and non-psychotropic compounds having FIASMA activity, to decrease the risk of death and/or intubation in patients suffering from a viral infection caused by at least one betacoronavirus, in particular SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2).

BR112022026283A 2020-06-24 2021-06-24 ACID SPHINGOMYELINASE INHIBITORS TO PREVENT AND TREAT COVID-19 DISEASE BR112022026283A2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP20305698.1A EP3928775A1 (en) 2020-06-24 2020-06-24 Use of antidepressant agents for treating the covid-19 disease
EP20306117.1A EP3973961A1 (en) 2020-09-29 2020-09-29 Use of hydroxyzine and antihistamine analogs for treating the covid-19 disease
US17/146,013 US20220347127A1 (en) 2021-01-11 2021-01-11 Use of antidepressant agents for preventing and treating the covid-19 disease
EP21305188 2021-02-12
PCT/EP2021/067427 WO2021260152A1 (en) 2020-06-24 2021-06-24 Inhibitors of acid sphingomyelinase for preventing and treating the covid-19 disease

Publications (1)

Publication Number Publication Date
BR112022026283A2 true BR112022026283A2 (en) 2023-03-07

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