BR112022007150A2 - METHODS OF TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA USING 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE- 1,3-DIONE - Google Patents

METHODS OF TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA USING 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE- 1,3-DIONE

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Publication number
BR112022007150A2
BR112022007150A2 BR112022007150A BR112022007150A BR112022007150A2 BR 112022007150 A2 BR112022007150 A2 BR 112022007150A2 BR 112022007150 A BR112022007150 A BR 112022007150A BR 112022007150 A BR112022007150 A BR 112022007150A BR 112022007150 A2 BR112022007150 A2 BR 112022007150A2
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BR
Brazil
Prior art keywords
morpholinoazetidin
dioxopiperidin
isoindoline
dione
fluoro
Prior art date
Application number
BR112022007150A
Other languages
Portuguese (pt)
Inventor
Janardhanan Preethi
Kasibhatla Shailaja
Lopez-Girona Antonia
POURDEHNAD Michael
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BR112022007150A2 publication Critical patent/BR112022007150A2/en

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Abstract

MÉTODOS DE TRATAMENTO DE LEUCEMIA LINFOCÍTICA CRÔNICA USANDO 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORFOLINOAZETIDIN-1-IL)METIL)BENZIL)AMINO)ISOINDOLINA-1,3-DIONA. São fornecidos no presente documento métodos de uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)benzil)amino)isoindolina-1,3-diona, ou um enantiômero, uma mistura de enantiômeros, um tautômero, um isotopólogo ou um sal farmaceuticamente aceitável da mesma, individualmente ou em combinação com obinutuzumabe, para tratar, prevenir ou controlar leucemia linfocítica crônica/linfoma linfocítico pequeno.METHODS OF TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA USING 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE- 1,3-DIONE. Methods of using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline are provided herein. -1,3-dione, or an enantiomer, a mixture of enantiomers, a tautomer, an isotopologist or a pharmaceutically acceptable salt thereof, alone or in combination with obinutuzumab, to treat, prevent or control chronic lymphocytic leukemia/small lymphocytic lymphoma.

BR112022007150A 2019-10-21 2020-10-20 METHODS OF TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA USING 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE- 1,3-DIONE BR112022007150A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962923955P 2019-10-21 2019-10-21
US202063011147P 2020-04-16 2020-04-16
US2021080936 2021-04-29

Publications (1)

Publication Number Publication Date
BR112022007150A2 true BR112022007150A2 (en) 2022-06-28

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BR112022007150A BR112022007150A2 (en) 2019-10-21 2020-10-20 METHODS OF TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA USING 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE- 1,3-DIONE

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BR (1) BR112022007150A2 (en)

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