BR112022005024A2 - Anti-nrp1a antibodies and their uses for the treatment of eyes or eye diseases - Google Patents

Anti-nrp1a antibodies and their uses for the treatment of eyes or eye diseases

Info

Publication number
BR112022005024A2
BR112022005024A2 BR112022005024A BR112022005024A BR112022005024A2 BR 112022005024 A2 BR112022005024 A2 BR 112022005024A2 BR 112022005024 A BR112022005024 A BR 112022005024A BR 112022005024 A BR112022005024 A BR 112022005024A BR 112022005024 A2 BR112022005024 A2 BR 112022005024A2
Authority
BR
Brazil
Prior art keywords
nrp1a
antibodies
eyes
treatment
eye diseases
Prior art date
Application number
BR112022005024A
Other languages
Portuguese (pt)
Inventor
Fei Han
Juergen Prestle
Leo Thomas
Nina Zippel
Pankaj Gupta
Sarah Low
Yining Huang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112022005024A2 publication Critical patent/BR112022005024A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

anticorpos anti-nrp1a e seus usos para o tratamento dos olhos ou doenças oculares. a presente invenção refere-se a anticorpos e fragmentos dos mesmos que se direcionam ao domínio a de neuropilina-1 (nrp1a). mais especificamente, os anticorpos anti-nrp1a e os métodos de uso para o trata-mento de várias doenças ou distúrbios são descritos.anti-nrp1a antibodies and their uses for treating eyes or eye diseases. the present invention relates to antibodies and fragments thereof that target the a domain of neuropilin-1 (nrp1a). more specifically, anti-nrp1a antibodies and methods of use for treating various diseases or disorders are described.

BR112022005024A 2019-09-24 2020-09-24 Anti-nrp1a antibodies and their uses for the treatment of eyes or eye diseases BR112022005024A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19199099 2019-09-24
EP20150942 2020-01-09
PCT/EP2020/076685 WO2021058636A1 (en) 2019-09-24 2020-09-24 Anti-nrp1a antibodies and their uses for treating eye or ocular diseases

Publications (1)

Publication Number Publication Date
BR112022005024A2 true BR112022005024A2 (en) 2022-06-21

Family

ID=72752879

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005024A BR112022005024A2 (en) 2019-09-24 2020-09-24 Anti-nrp1a antibodies and their uses for the treatment of eyes or eye diseases

Country Status (16)

Country Link
US (2) US11661458B2 (en)
EP (1) EP4034161A1 (en)
JP (1) JP2022549005A (en)
KR (1) KR20220069076A (en)
CN (1) CN114423788A (en)
AU (1) AU2020355599A1 (en)
BR (1) BR112022005024A2 (en)
CA (1) CA3154654A1 (en)
CO (1) CO2022003324A2 (en)
CR (1) CR20220122A (en)
IL (1) IL291522A (en)
JO (1) JOP20220074A1 (en)
MX (1) MX2022003544A (en)
PE (1) PE20221315A1 (en)
TW (1) TW202126685A (en)
WO (1) WO2021058636A1 (en)

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Also Published As

Publication number Publication date
WO2021058636A1 (en) 2021-04-01
MX2022003544A (en) 2022-04-11
JOP20220074A1 (en) 2023-01-30
CR20220122A (en) 2022-05-05
EP4034161A1 (en) 2022-08-03
CA3154654A1 (en) 2021-04-01
US20230416378A1 (en) 2023-12-28
AU2020355599A1 (en) 2022-04-07
JP2022549005A (en) 2022-11-22
CO2022003324A2 (en) 2022-04-19
US20210087282A1 (en) 2021-03-25
PE20221315A1 (en) 2022-09-07
CN114423788A (en) 2022-04-29
KR20220069076A (en) 2022-05-26
US11661458B2 (en) 2023-05-30
IL291522A (en) 2022-05-01
TW202126685A (en) 2021-07-16

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