BR112021026406A2 - Chimeric antigen receptor with co-tumulatory domain 4-1bb - Google Patents

Chimeric antigen receptor with co-tumulatory domain 4-1bb

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Publication number
BR112021026406A2
BR112021026406A2 BR112021026406A BR112021026406A BR112021026406A2 BR 112021026406 A2 BR112021026406 A2 BR 112021026406A2 BR 112021026406 A BR112021026406 A BR 112021026406A BR 112021026406 A BR112021026406 A BR 112021026406A BR 112021026406 A2 BR112021026406 A2 BR 112021026406A2
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BR
Brazil
Prior art keywords
domain
antigen receptor
chimeric antigen
car
tumulatory
Prior art date
Application number
BR112021026406A
Other languages
Portuguese (pt)
Inventor
Bo-Rim Yi
S Kwon Byoung
Hye Yoo Eun
Mi Lee Hye
Hyuntae Son
Jiwon Chung
Jungyun Lee
Kwanghee Kim
Rom Lee Sae
Gyoon Chang Young
Original Assignee
Eutilex Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/KR2019/010244 external-priority patent/WO2020032784A1/en
Application filed by Eutilex Co Ltd filed Critical Eutilex Co Ltd
Publication of BR112021026406A2 publication Critical patent/BR112021026406A2/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464474—Proteoglycans, e.g. glypican, brevican or CSPG4
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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Abstract

receptor de antígeno quimérico com domínio coestumulatório 4-1bb. a presente invenção refere-se a composições de car-t que se referem a um car incluindo (i) um domínio extracelular compreendendo um domínio de ligação ao antígeno; (ii) um domínio transmembrana; e (iii) um domínio intracelular compreendendo um endodomínio coestimulatório, em que o endodomínio coestimulatório compreende um domínio de sinalização intracelular de 4-1bb/cd137 e cinco aminoácidos adicionais a divulgação também provê vetores, composições e métodos de tratamento usando as moléculas de ligação ao antígeno e células imune modificadas geneticamente compreendendo o car. as composições de car aqui providas podem ser usadas para o tratamento de determinados cânceres.chimeric antigen receptor with costumulatory domain 4-1bb. the present invention relates to car-t compositions which refer to a car including (i) an extracellular domain comprising an antigen-binding domain; (ii) a transmembrane domain; and (iii) an intracellular domain comprising a costimulatory endodomain, wherein the costimulatory endodomain comprises an intracellular signaling domain of 4-1bb/cd137 and five additional amino acids. antigen and genetically modified immune cells comprising the car. the carbon compositions provided herein can be used for the treatment of certain cancers.

BR112021026406A 2019-06-27 2020-06-26 Chimeric antigen receptor with co-tumulatory domain 4-1bb BR112021026406A2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962867503P 2019-06-27 2019-06-27
PCT/KR2019/010244 WO2020032784A1 (en) 2018-08-10 2019-08-12 Chimeric antigen receptor binding to hla-dr, and car-t cell
US16/715,462 US11013765B2 (en) 2018-08-10 2019-12-16 Chimeric antigen receptor that binds HLA-DR and CAR-T cell
US202062991493P 2020-03-18 2020-03-18
US202063004827P 2020-04-03 2020-04-03
US202063043237P 2020-06-24 2020-06-24
PCT/IB2020/056097 WO2020261231A1 (en) 2019-06-27 2020-06-26 Chimeric antigen receptor with 4-1bb costimulatory domain

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BR112021026406A2 true BR112021026406A2 (en) 2022-04-12

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BR112021026406A BR112021026406A2 (en) 2019-06-27 2020-06-26 Chimeric antigen receptor with co-tumulatory domain 4-1bb

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EP (1) EP3990626A4 (en)
JP (1) JP2022538425A (en)
KR (1) KR20220030248A (en)
CN (1) CN114080452A (en)
AU (1) AU2020307673A1 (en)
BR (1) BR112021026406A2 (en)
CA (1) CA3144875A1 (en)
MX (1) MX2021015967A (en)
WO (1) WO2020261231A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020265679A1 (en) 2019-04-30 2021-12-23 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof
KR102671410B1 (en) * 2021-03-03 2024-06-04 진화섭 Chimeric antigen receptor specifically binding to RANK ligand and use thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050113564A1 (en) * 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
JP4331227B2 (en) * 2004-07-09 2009-09-16 中外製薬株式会社 Anti-glypican 3 antibody
AU2013204922B2 (en) * 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
US20160280798A1 (en) * 2013-11-06 2016-09-29 The United States Of America, As Represented By The Secretary Department Of Health & Human Service Alk antibodies, conjugates, and chimeric antigen receptors, and their use
CA2951045A1 (en) * 2014-06-02 2015-12-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting cd-19
US10195272B2 (en) * 2015-03-02 2019-02-05 The Nemours Foundation Adoptive t-cell therapy using FcεRI-based chimeric antigen receptors for treating IgE-mediated allergic diseases
JP7010473B2 (en) * 2015-06-04 2022-02-10 ユニバーシティ オブ サザン カリフォルニア LYM-1 and LYM-2 Targeted CAR Cell Immunotherapy
US10421810B2 (en) * 2015-10-09 2019-09-24 Lentigen Technology, Inc. Chimeric antigen receptors and methods of use
CN106279438B (en) * 2016-08-24 2019-10-22 北京领柯生物科技有限公司 Novel chimeric antigen receptor and application thereof
US11286306B2 (en) * 2016-12-09 2022-03-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. TLR9-binding chimeric antigen receptors
KR102664453B1 (en) * 2017-02-21 2024-05-10 주식회사 유틸렉스 HLA-DR CAR-T compositions and methods of making and using them
WO2018156711A1 (en) * 2017-02-22 2018-08-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. Il13ra2-binding chimeric antigen receptors
WO2018236909A1 (en) * 2017-06-20 2018-12-27 La Jolla Institute For Allergy And Immunology Engineered t-cell receptors and methods of their use in modulating inflammatory responses and treating atherosclerosis
CN111183156A (en) * 2017-07-31 2020-05-19 莱蒂恩技术公司 Compositions and methods for treating cancer with anti-CD 19/CD20 immunotherapy
CN108715859B (en) * 2018-05-31 2021-08-03 中国医学科学院血液病医院(中国医学科学院血液学研究所) Chimeric antigen receptor targeting CD22 and application thereof

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WO2020261231A1 (en) 2020-12-30
JP2022538425A (en) 2022-09-02
AU2020307673A1 (en) 2022-01-20
MX2021015967A (en) 2022-04-06
EP3990626A4 (en) 2023-09-20
CN114080452A (en) 2022-02-22
EP3990626A1 (en) 2022-05-04
CA3144875A1 (en) 2020-12-30
KR20220030248A (en) 2022-03-10

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