BR112021025943A2 - Innovative tumor-specific antigens for ovarian cancer and uses thereof - Google Patents

Innovative tumor-specific antigens for ovarian cancer and uses thereof

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Publication number
BR112021025943A2
BR112021025943A2 BR112021025943A BR112021025943A BR112021025943A2 BR 112021025943 A2 BR112021025943 A2 BR 112021025943A2 BR 112021025943 A BR112021025943 A BR 112021025943A BR 112021025943 A BR112021025943 A BR 112021025943A BR 112021025943 A2 BR112021025943 A2 BR 112021025943A2
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BR
Brazil
Prior art keywords
ovarian cancer
tsas
hgsc
specific antigens
innovative
Prior art date
Application number
BR112021025943A
Other languages
Portuguese (pt)
Inventor
Claude Perrault
Pierre Thibault
Qingchuan Zhao
Sébastien Lemieux
Original Assignee
Univ Montreal
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Filing date
Publication date
Application filed by Univ Montreal filed Critical Univ Montreal
Publication of BR112021025943A2 publication Critical patent/BR112021025943A2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/892—Reproductive system [uterus, ovaries, cervix, testes]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

Abstract

antígenos específicos de tumor inovadores para câncer de ovário e usos dos mesmos. o câncer de ovário, particularmente o câncer de ovário seroso de alto grau (hgsc), que é a principal causa de morte por malignidades ginecológicas no mundo, não se beneficiou significativamente do progresso recente na imunoterapia contra o câncer. embora a infiltração de hgsc por linfócitos se correlacione com a sobrevivência superior, a natureza dos antígenos que podem desencadear respostas imunes anti-hgsc é desconhecida. antígenos específicos de tumor (tsas) inovadores compartilhados por uma grande proporção de tumores ovarianos são descritos no presente documento. a maioria dos tsas (> 80%) aqui descritos deriva de sequências genômicas não mutadas expressas de forma aberrante, tais como sequências intrônicas e intergênicas, que não são expressas em tecidos normais. são descritos ácidos nucleicos, composições, células e vacinas derivadas desses tsas. o uso dos tsas, ácidos nucleicos, composições, células e vacinas para o tratamento de câncer de ovário também é descrito.innovative tumor-specific antigens for ovarian cancer and uses thereof. Ovarian cancer, particularly high-grade serous ovarian cancer (hgsc), which is the leading cause of death from gynecologic malignancies worldwide, has not benefited significantly from recent progress in cancer immunotherapy. although infiltration of hgsc by lymphocytes correlates with superior survival, the nature of the antigens that can trigger anti-hgsc immune responses is unknown. Innovative tumor-specific antigens (tsas) shared by a large proportion of ovarian tumors are described herein. most of the tsas (>80%) described here are derived from aberrantly expressed unmutated genomic sequences, such as intronic and intergenic sequences, that are not expressed in normal tissues. Nucleic acids, compositions, cells and vaccines derived from these tsas are described. the use of the tsas, nucleic acids, compositions, cells and vaccines for the treatment of ovarian cancer is also described.

BR112021025943A 2019-06-25 2020-06-22 Innovative tumor-specific antigens for ovarian cancer and uses thereof BR112021025943A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962866089P 2019-06-25 2019-06-25
PCT/CA2020/050869 WO2020257922A1 (en) 2019-06-25 2020-06-22 Novel tumor-specific antigens for ovarian cancer and uses thereof

Publications (1)

Publication Number Publication Date
BR112021025943A2 true BR112021025943A2 (en) 2022-02-08

Family

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Family Applications (1)

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BR112021025943A BR112021025943A2 (en) 2019-06-25 2020-06-22 Innovative tumor-specific antigens for ovarian cancer and uses thereof

Country Status (12)

Country Link
US (1) US20220354937A1 (en)
EP (1) EP3990483A4 (en)
JP (1) JP2022539301A (en)
KR (1) KR20220025808A (en)
CN (1) CN114026117A (en)
AU (1) AU2020301838A1 (en)
BR (1) BR112021025943A2 (en)
CA (1) CA3141898A1 (en)
IL (1) IL288826A (en)
MX (1) MX2022000046A (en)
SG (1) SG11202113192QA (en)
WO (1) WO2020257922A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020041876A1 (en) 2018-08-30 2020-03-05 Université de Montréal Proteogenomic-based method for identifying tumor-specific antigens
WO2023023840A1 (en) * 2021-07-16 2023-03-02 Université de Montréal Novel tumor-specific antigens for cancer stem cells and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003111595A (en) * 2001-06-25 2003-04-15 Kyogo Ito Tumor antigen
EP3777882A1 (en) * 2013-07-30 2021-02-17 BioNTech SE Tumor antigens for determining cancer therapy
GB201511191D0 (en) * 2015-06-25 2015-08-12 Immatics Biotechnologies Gmbh T-cell epitopes for the immunotherapy of myeloma
GB201512369D0 (en) * 2015-07-15 2015-08-19 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
GB201517538D0 (en) * 2015-10-05 2015-11-18 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
GB201604490D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
MA47367B1 (en) * 2017-01-27 2023-06-28 Immatics Biotechnologies Gmbh NOVEL PEPTIDES AND COMBINATIONS OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST OVARIAN CANCER AND OTHER CANCERS
BR112021026375A2 (en) * 2019-06-28 2022-05-10 Enara Bio Ltd Innovative cancer antigens and methods

Also Published As

Publication number Publication date
WO2020257922A1 (en) 2020-12-30
EP3990483A1 (en) 2022-05-04
JP2022539301A (en) 2022-09-08
MX2022000046A (en) 2022-02-24
AU2020301838A1 (en) 2022-02-10
SG11202113192QA (en) 2021-12-30
US20220354937A1 (en) 2022-11-10
IL288826A (en) 2022-02-01
CA3141898A1 (en) 2020-12-30
CN114026117A (en) 2022-02-08
KR20220025808A (en) 2022-03-03
EP3990483A4 (en) 2024-02-21

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