BR112021023832A2 - Métodos e composições para geração de óxido nítrico e usos dos mesmos - Google Patents

Métodos e composições para geração de óxido nítrico e usos dos mesmos

Info

Publication number
BR112021023832A2
BR112021023832A2 BR112021023832A BR112021023832A BR112021023832A2 BR 112021023832 A2 BR112021023832 A2 BR 112021023832A2 BR 112021023832 A BR112021023832 A BR 112021023832A BR 112021023832 A BR112021023832 A BR 112021023832A BR 112021023832 A2 BR112021023832 A2 BR 112021023832A2
Authority
BR
Brazil
Prior art keywords
nitric oxide
compositions
methods
organic
generating nitric
Prior art date
Application number
BR112021023832A
Other languages
English (en)
Other versions
BR112021023832A8 (pt
Inventor
Barry Wood Christopher
Semple Munro Hugh
Original Assignee
Thirty Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1907969.8A external-priority patent/GB201907969D0/en
Priority claimed from GB201915280A external-priority patent/GB201915280D0/en
Priority claimed from GBGB2005980.4A external-priority patent/GB202005980D0/en
Application filed by Thirty Holdings Ltd filed Critical Thirty Holdings Ltd
Publication of BR112021023832A2 publication Critical patent/BR112021023832A2/pt
Publication of BR112021023832A8 publication Critical patent/BR112021023832A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B21/00—Nitrogen; Compounds thereof
    • C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
    • C01B21/24—Nitric oxide (NO)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

métodos e composições para geração de óxido nítrico e usos dos mesmos. a invenção fornece uma combinação, kit ou composição compreendendo: (i) um ou mais sais de nitrito; (ii) uma fonte de próton compreendendo um ou mais ácidos selecionados de ácidos carboxílicos orgânicos e ácidos orgânicos não carboxílicos redutores; e (iii) um ou mais polióis orgânicos. na reação do um ou mais sais de nitrito com a fonte de próton na presença do um ou mais polióis orgânicos, a combinação, kit ou composição fornece produtos de reação que incluem óxido nítrico, opcionalmente outros óxidos de nitrogênio e/ou opcionalmente precursores dos mesmos e que são úteis, por exemplo, no tratamento de vários distúrbios.
BR112021023832A 2019-06-04 2020-06-02 Métodos e composições para geração de óxido nítrico e usos dos mesmos BR112021023832A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1907969.8A GB201907969D0 (en) 2019-06-04 2019-06-04 Methods and compositions for generating nitric oxide and uses thereof
GB201915280A GB201915280D0 (en) 2019-10-22 2019-10-22 Methods and compositions for generating nitric oxide and uses thereof
GBGB2005980.4A GB202005980D0 (en) 2020-04-23 2020-04-23 Methods and compositions for generating nitric oxide and uses thereof
PCT/GB2020/051328 WO2020245573A1 (en) 2019-06-04 2020-06-02 Methods and compositions for generating nitric oxide and uses thereof

Publications (2)

Publication Number Publication Date
BR112021023832A2 true BR112021023832A2 (pt) 2022-01-04
BR112021023832A8 BR112021023832A8 (pt) 2023-02-28

Family

ID=71083655

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021023832A BR112021023832A8 (pt) 2019-06-04 2020-06-02 Métodos e composições para geração de óxido nítrico e usos dos mesmos

Country Status (9)

Country Link
US (1) US20220370493A1 (pt)
EP (1) EP3980373A1 (pt)
JP (1) JP2023510661A (pt)
CN (1) CN114206325A (pt)
AU (1) AU2020286677A1 (pt)
BR (1) BR112021023832A8 (pt)
CA (1) CA3142101A1 (pt)
GB (1) GB2599576B (pt)
WO (1) WO2020245573A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
WO2021214440A1 (en) * 2020-04-23 2021-10-28 Thirty Respiratory Limited Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2
BR112022021436A2 (pt) * 2020-04-23 2023-01-17 Thirty Respiratory Ltd Métodos e composições para tratamento e combate da tuberculose
JPWO2021256540A1 (pt) * 2020-06-19 2021-12-23
GB202215758D0 (en) * 2022-10-25 2022-12-07 Thirty Holdings Ltd Implantable medical devices

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826255A (en) 1972-06-22 1974-07-30 Hudson Oxygen Therapy Sales Co Intermittent positive pressure breathing manifold
YU41046B (en) 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
US4130639A (en) 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
US4253468A (en) 1978-08-14 1981-03-03 Steven Lehmbeck Nebulizer attachment
US4263907A (en) 1979-05-14 1981-04-28 Lindsey Joseph W Respirator nebulizer
US4510929A (en) 1982-04-30 1985-04-16 Bordoni Maurice E Disposable radioactive aerosol inhalation apparatus
US4649911A (en) 1983-09-08 1987-03-17 Baylor College Of Medicine Small particle aerosol generator for treatment of respiratory disease including the lungs
US4624251A (en) 1984-09-13 1986-11-25 Riker Laboratories, Inc. Apparatus for administering a nebulized substance
NZ241579A (en) 1991-03-25 1994-04-27 Becton Dickinson Co Antimicrobial formulations for treating the skin
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
EP0540775B1 (de) 1991-11-07 1997-07-23 PAUL RITZAU PARI-WERK GmbH Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5709202A (en) 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
AU7920394A (en) 1993-10-06 1995-05-01 Henkel Corporation Improving phenolic disinfectant cleaning compositions with alkylpolyglucoside surfactants
US6034133A (en) 1993-11-05 2000-03-07 The University Of Virginia Patents Foundation Use of a virucidal hand lotion to prevent the spread of rhinovirus colds
GB9804469D0 (en) 1998-03-02 1998-04-29 Univ Aberdeen Antiviral composition
CA2183549C (en) 1994-02-21 2006-09-12 Nigel Benjamin Acidified nitrite as an antimicrobial agent
US5681802A (en) 1994-06-01 1997-10-28 Lever Brothers Company, Division Of Conopco, Inc. Mild antimicrobial liquid cleansing formulations comprising buffering compound or compounds as potentiator of antimicrobial effectiveness
US5635462A (en) 1994-07-08 1997-06-03 Gojo Industries, Inc. Antimicrobial cleansing compositions
US5776430A (en) 1994-11-01 1998-07-07 Calgon Vestal, Inc. Topical antimicrobial cleanser containing chlorhexidine gluconate and alcohol
US5702754A (en) 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
WO1996025918A1 (en) 1995-02-24 1996-08-29 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
ZA962455B (en) 1995-03-31 1996-10-02 B Eugene Guthery Fast acting and persistent topical antiseptic
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
US6083922A (en) 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
JP2002514163A (ja) 1996-07-10 2002-05-14 ステリス インコーポレイテッド 改良された有効性を有するトリクロサンスキンウォッシュ
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6258368B1 (en) 1997-06-04 2001-07-10 The Procter & Gamble Company Antimicrobial wipes
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
WO1999017754A1 (en) 1997-10-08 1999-04-15 Sepracor Inc. Dosage form for aerosol administration
DE69802252T2 (de) 1997-11-19 2002-07-04 Microflow Eng Sa Tröpfchen-Vernebler und Zerstäubungsdüse für einen therapeutischen Inhalator
US6192876B1 (en) 1997-12-12 2001-02-27 Astra Aktiebolag Inhalation apparatus and method
US6258371B1 (en) 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
DE69934315T2 (de) 1998-07-31 2007-07-05 First Water Ltd., Marlborough Bioadhesive zusammensetzungen mit hydrophobe polymeren
GB2343122B (en) 1998-10-26 2003-01-08 Medic Aid Ltd Improvements in and relating to nebulisers
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
US6584971B1 (en) 1999-01-04 2003-07-01 Medic-Aid Limited Drug delivery apparatus
GB9905425D0 (en) 1999-03-09 1999-05-05 Queen Mary & Westfield College Pharmaceutical composition
JP2000355667A (ja) 1999-04-14 2000-12-26 Seiko Epson Corp カラーインクジェット記録用水系顔料インクセット、カラーインクジェット記録方法、及びカラーインクジェット記録物
US6338443B1 (en) 1999-06-18 2002-01-15 Mercury Enterprises, Inc. High efficiency medical nebulizer
US6107261A (en) 1999-06-23 2000-08-22 The Dial Corporation Compositions containing a high percent saturation concentration of antibacterial agent
WO2001076671A2 (en) 2000-04-11 2001-10-18 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
GB0021317D0 (en) 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
GB0022084D0 (en) * 2000-09-08 2000-10-25 Univ Aberdeen Treatment of multiply antibiotic-resistant organisms
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
GB0119011D0 (en) 2001-08-03 2001-09-26 Univ Aberdeen Treatment of nail infections
US7135189B2 (en) 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
GB0125222D0 (en) 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US7066356B2 (en) 2002-08-15 2006-06-27 Ecolab Inc. Foam soap dispenser for push operation
EP1718603A4 (en) 2004-02-09 2009-09-23 Noxilizer Inc MOLECULES RELEASING NITROGEN MONOXIDE
US7838532B2 (en) 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
EP1917047B1 (en) 2005-07-14 2019-09-04 First Water Limited Treatment of chronic ulcerous skin lesions
CN101028229B (zh) 2006-03-02 2012-09-05 北京富丽华德生物医药科技有限公司 基于一氧化氮的新型化妆品
CN101062050A (zh) 2006-04-29 2007-10-31 北京尼奥克斯生物科技有限公司 一种基于一氧化氮的新型生发产品及其制备方法
WO2007142919A2 (en) 2006-05-30 2007-12-13 The Dial Corporation Compositions having a high antiviral effeicacy
WO2008110872A2 (en) 2006-06-23 2008-09-18 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
GB0700908D0 (en) 2007-01-17 2007-02-28 First Water Ltd Inhibition of proteases, particularly in the treatment of chronic ulcerous skin lesions
GB0700911D0 (en) 2007-01-17 2007-02-28 First Water Ltd Treatment of inflammation and the complement and kinin cascades in a patient, particularly in chronic ulcerous skin lesions
GB0715556D0 (en) 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
US9278157B2 (en) * 2007-08-09 2016-03-08 Insense Limited Nitric oxide-generating skin dressings
CA2710349A1 (en) 2007-12-27 2009-07-09 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof
US8568793B2 (en) 2009-02-11 2013-10-29 Hope Medical Enterprises, Inc. Sodium nitrite-containing pharmaceutical compositions
JP2011010865A (ja) * 2009-06-30 2011-01-20 Ikaria Holdings Inc 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法
WO2011155887A1 (en) * 2010-06-07 2011-12-15 Topical Pharma Ab Kit for the treatment of onychomycosis by nitric oxide
US20130200109A1 (en) 2012-02-06 2013-08-08 Frank Yang Foaming soap dispensers and methods
CN103622917B (zh) 2012-08-23 2017-12-29 尼奥克斯(文莱)控股有限公司 基于微囊化亚硝酸盐和酸化水凝胶的延时产生一氧化氮的系统和方法
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
GB201309092D0 (en) 2013-05-20 2013-07-03 Edixomed Ltd Transdermal delivery system
GB201309091D0 (en) 2013-05-20 2013-07-03 Edixomed Ltd Dressing system
WO2015138406A1 (en) 2014-03-14 2015-09-17 12th Man Technologies, Inc. Treating diseases using nitric oxide releasing solutions
DK3407900T3 (da) 2016-01-27 2024-04-02 Syk Tech Llc Apparatur til topisk anvendelse af kvældstofoxid samt fremgangsmåder

Also Published As

Publication number Publication date
US20220370493A1 (en) 2022-11-24
JP2023510661A (ja) 2023-03-15
WO2020245573A1 (en) 2020-12-10
GB2599576A (en) 2022-04-06
EP3980373A1 (en) 2022-04-13
GB2599576B (en) 2023-09-13
CA3142101A1 (en) 2020-12-10
BR112021023832A8 (pt) 2023-02-28
CN114206325A (zh) 2022-03-18
AU2020286677A1 (en) 2021-12-09

Similar Documents

Publication Publication Date Title
BR112021023832A2 (pt) Métodos e composições para geração de óxido nítrico e usos dos mesmos
BR112021023632A2 (pt) Métodos e composições para gerar óxido nítrico e usos do mesmo para entregar óxido nítrico através do trato respiratório
BR112018067442A2 (pt) composto, composição farmacêutica, método de inibir a atividade da amina oxidase, método de tratar uma condição e uso de um composto
NZ759766A (en) Use of lactic acid bacteria to treat or prevent at least one of postnatal depression and postnatal anxiety
BR112014020021A8 (pt) Composição, método para melhorar a atividade antimicrobiana de um biocida, e, usos de uma poliamina e de uma composição
BR112021022758A2 (pt) Compostos de 1-oxo-isoindolina-5-carboxamida substituídos, suas composições e métodos de tratamento com os mesmos
BR112014011896A2 (pt) agentes de rnai, composições e métodos de uso destes para o tratamento de doenças associadas à transtirretina (ttr)
BR112017015773A2 (pt) muteína de lipocalina, muteína de hngal, molécula de ácido nucleico, célula hospedeira, método para produzir a muteína de hngal, composição farmacêutica, kit, uso da muteína de hngal, uso da muteína de hngal, método para ligar ang-2 em um indivíduo, método para inibir angiogênese em um indivíduo, método para tratar, prevenir ou melhorar uma doença e método para inibir ou reduzir angiogênese em um indivíduo
CL2007003666A1 (es) Compuestos derivados del acido nicotinico; composicion farmaceutica que comprende a dichos compuestos; combinacion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de artritis, esclerosis multiple, psoriasis, entre otras.
BR112019024785A2 (pt) composto de bifenila ou sal do mesmo, composição farmacêutica, agente antineoplásico e uso
BRPI0903359B8 (pt) composição farmacêutica de metformina, ácido acetilsalicílico e composto de serotonina para o tratamento do câncer
BR112017009028A2 (pt) métodos e sistema para suprimir corrosão em superfícies de metal.
MX2022001004A (es) Inhibidores de enzimas.
BR112018072339A2 (pt) tratamento de distúrbios de perda de cabelo com inibidores de jak deuterados
BR112019007543A2 (pt) inibidores de ácido alfa-amino-beta-carboximuconico semialdeido decarboxilase
BR112022021454A2 (pt) Óxido nítrico ou composições liberadoras de óxido nítrico para uso no tratamento de sars-cov e sars-cov-2
BR112022023013A2 (pt) Inibidores de mek para tratamento ou prevenção de infecções por coronavírus e/ou de tempestade de citocinas de covid-19
CO2022000270A2 (es) Inhibidores de enzimas
BR112018009837A2 (pt) composição catalítica e composição curável
CL2019001746A1 (es) Amidas aromáticas de ácido carboxílico
BR112022008544A2 (pt) Composições e métodos e usos relacionados às mesmas
WO2020247701A3 (en) Inhibitors of sarm1
CO2022000266A2 (es) Inhibidores de enzimas
BR112022001054A2 (pt) Inibidores enzimáticos
BR112017023164A2 (pt) composto, e, método de prevenir e/ou tratar a esteato-hepatite não alcoólica em um indivíduo em necessidade do mesmo