BR112021022451A2 - Genoma sintético - Google Patents

Genoma sintético

Info

Publication number
BR112021022451A2
BR112021022451A2 BR112021022451A BR112021022451A BR112021022451A2 BR 112021022451 A2 BR112021022451 A2 BR 112021022451A2 BR 112021022451 A BR112021022451 A BR 112021022451A BR 112021022451 A BR112021022451 A BR 112021022451A BR 112021022451 A2 BR112021022451 A2 BR 112021022451A2
Authority
BR
Brazil
Prior art keywords
genome
synthetic
codons
sense
synthetic genome
Prior art date
Application number
BR112021022451A
Other languages
English (en)
Inventor
De La Torre Daniel
W Chin Jason
Julius Fredens
Kaihang Wang
F H Funke Louise
E Robertson Wesley
Original Assignee
Scarab Genomics Llc
Res & Innovation Uk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scarab Genomics Llc, Res & Innovation Uk filed Critical Scarab Genomics Llc
Publication of BR112021022451A2 publication Critical patent/BR112021022451A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1031—Mutagenizing nucleic acids mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

genoma sintético. a presente invenção fornece um genoma procariótico sintético que compreende 5 ou menos ocorrências de um ou mais códons senso; e/ou um genoma procariótico sintético derivado de um genoma progenitor, em que o genoma procariótico sintético compreende menos de 10%, 5%, 2%, 1%, 0,5%, 0,1% das ocorrências de um ou mais códons senso, em relação ao genoma progenitor; e/ou um genoma procariótico sintético que compreende 100 ou mais, 200 ou mais ou 1000 ou mais genes sem ocorrências de um ou mais códons senso.
BR112021022451A 2019-05-14 2020-05-14 Genoma sintético BR112021022451A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1906775.0A GB201906775D0 (en) 2019-05-14 2019-05-14 Synthetic genome
PCT/EP2020/063445 WO2020229592A1 (en) 2019-05-14 2020-05-14 Synthetic genome

Publications (1)

Publication Number Publication Date
BR112021022451A2 true BR112021022451A2 (pt) 2022-02-15

Family

ID=67384685

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021022451A BR112021022451A2 (pt) 2019-05-14 2020-05-14 Genoma sintético

Country Status (9)

Country Link
US (2) US20220282241A1 (pt)
EP (1) EP3969582A1 (pt)
JP (1) JP2022533040A (pt)
CN (1) CN114026230A (pt)
AU (1) AU2020273571A1 (pt)
BR (1) BR112021022451A2 (pt)
CA (1) CA3135971A1 (pt)
GB (1) GB201906775D0 (pt)
WO (1) WO2020229592A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240117295A1 (en) 2021-05-28 2024-04-11 United Kingdom Research And Innovation Microorganisms and uses thereof
GB202110137D0 (en) 2021-07-14 2021-08-25 Res & Innovation Uk Methods for optimising protein production
WO2023034856A1 (en) * 2021-08-31 2023-03-09 New York University COMPOSITIONS AND METHODS FOR SWITCHING ANTIBIOTIC RESISTANCE MARKERS PROGRESSIVELY FOR INTEGRATION (mSwAP-In)
WO2023205267A1 (en) * 2022-04-20 2023-10-26 The Administrators Of The Tulane Educational Fund Enhanced cell-free bacteriophage synthesis by genetic modulation of bacterial transcription/translation machinery (txtl) machinery
WO2024017956A2 (en) 2022-07-19 2024-01-25 United Kingdom Research And Innovation Genetic codes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012164083A1 (en) * 2011-06-01 2012-12-06 Actogenix N.V. Polycistronic expression system for bacteria
EP3149176B1 (en) * 2014-05-30 2019-10-23 The Trustees of Columbia University in the City of New York Methods for altering polypeptide expression
GB201613135D0 (en) * 2016-07-29 2016-09-14 Medical Res Council Genome editing

Also Published As

Publication number Publication date
US20240132874A1 (en) 2024-04-25
US20230392138A1 (en) 2023-12-07
CA3135971A1 (en) 2020-11-19
AU2020273571A1 (en) 2021-10-14
WO2020229592A1 (en) 2020-11-19
US20220282241A1 (en) 2022-09-08
EP3969582A1 (en) 2022-03-23
JP2022533040A (ja) 2022-07-21
CN114026230A (zh) 2022-02-08
GB201906775D0 (en) 2019-06-26

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