BR112021020048A2 - Method for obtaining low molecular weight heparins through tangential flow filtration - Google Patents
Method for obtaining low molecular weight heparins through tangential flow filtrationInfo
- Publication number
- BR112021020048A2 BR112021020048A2 BR112021020048A BR112021020048A BR112021020048A2 BR 112021020048 A2 BR112021020048 A2 BR 112021020048A2 BR 112021020048 A BR112021020048 A BR 112021020048A BR 112021020048 A BR112021020048 A BR 112021020048A BR 112021020048 A2 BR112021020048 A2 BR 112021020048A2
- Authority
- BR
- Brazil
- Prior art keywords
- molecular weight
- low molecular
- tangential flow
- flow filtration
- obtaining low
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000009295 crossflow filtration Methods 0.000 title abstract 3
- 229940127215 low-molecular weight heparin Drugs 0.000 title abstract 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 3
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 229960003616 bemiparin Drugs 0.000 abstract 1
- 238000011026 diafiltration Methods 0.000 abstract 1
- 229960000610 enoxaparin Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 239000003055 low molecular weight heparin Substances 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/10—Heparin; Derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/16—Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2649—Filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/10—Cross-flow filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/16—Diafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/20—Specific permeability or cut-off range
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Water Supply & Treatment (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
método para obtenção de heparinas de baixo peso molecular através de filtração de fluxo tangencial. método para obtenção de heparinas de baixo peso molecular (hbpm) com distribuição de peso molecular entre 3,0 e 5,0 kda compreendendo pelo menos uma etapa de concentração através de filtração de fluxo tangencial (tff). o método é particularmente útil para a preparação de bemiparina e enoxaparina sem a utilização de precipitação fracionada nem o uso de soluções alcoólicas. em particular, a preparação da hbpm é obtida através da despolimerização da heparina e filtração (ultrafiltração e/ou diafiltração de tff) da heparina despolimerizada sem o uso de precipitação fracionada e sem uma solução alcoólica.method for obtaining low molecular weight heparins through tangential flow filtration. method for obtaining low molecular weight heparins (hbpm) with molecular weight distribution between 3.0 and 5.0 kda comprising at least one concentration step through tangential flow filtration (tff). The method is particularly useful for the preparation of bemiparin and enoxaparin without the use of fractional precipitation or the use of alcoholic solutions. in particular, the preparation of hbpm is obtained through the depolymerization of heparin and filtration (ultrafiltration and/or tff diafiltration) of the depolymerized heparin without the use of fractional precipitation and without an alcoholic solution.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201930373 | 2019-04-26 | ||
| CN202010078241 | 2020-01-23 | ||
| PCT/ES2020/070263 WO2020216981A1 (en) | 2019-04-26 | 2020-04-24 | Method for obtaining low-molecular-weight heparins by means of tangential flow filtration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021020048A2 true BR112021020048A2 (en) | 2021-12-07 |
Family
ID=72941056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021020048A BR112021020048A2 (en) | 2019-04-26 | 2020-04-24 | Method for obtaining low molecular weight heparins through tangential flow filtration |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20220112315A1 (en) |
| EP (1) | EP3943513A4 (en) |
| JP (1) | JP2022530321A (en) |
| KR (1) | KR20220005441A (en) |
| AU (1) | AU2020263142A1 (en) |
| BR (1) | BR112021020048A2 (en) |
| CA (1) | CA3134458C (en) |
| CL (1) | CL2021002647A1 (en) |
| CO (1) | CO2021013320A2 (en) |
| ES (1) | ES2888148B2 (en) |
| GE (1) | GEP20247598B (en) |
| IL (1) | IL286931A (en) |
| MA (1) | MA55388A (en) |
| MX (1) | MX2021011671A (en) |
| PE (1) | PE20212330A1 (en) |
| SG (1) | SG11202111009WA (en) |
| WO (1) | WO2020216981A1 (en) |
| ZA (1) | ZA202109022B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022273722A1 (en) * | 2021-05-12 | 2023-11-02 | NexEos Diagnostics, Inc. | Methods of manufacturing a high molecular weight heparin compound |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0245813B2 (en) | 1986-05-16 | 2000-03-22 | ITALFARMACO S.p.A. | EDTA-free heparins, heparin fractions and fragments, processes for their preparation and pharmaceutical compositions containing them |
| US5767269A (en) | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
| ES2161615B1 (en) | 1999-07-23 | 2003-03-16 | Rovi Lab Farmaceut Sa | COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT. |
| GB0509433D0 (en) | 2005-05-09 | 2005-06-15 | Uni For Milj Og Biovitenskap | Method |
| US8598337B2 (en) | 2006-01-13 | 2013-12-03 | Baxter International Inc. | Method for purifying polysaccharides |
| EP2411002B1 (en) | 2009-03-27 | 2019-01-02 | Algenist Holdings, Inc, | Microalgal polysaccharide compositions |
| CN102050888B (en) | 2010-12-13 | 2011-12-07 | 河北常山生化药业股份有限公司 | Method for preparing enoxaparin sodium |
| CN102731683A (en) * | 2012-07-17 | 2012-10-17 | 湖北亿诺瑞生物制药有限公司 | Method of separating natural low molecular heparin from heparin waste liquor |
| CN103342761B (en) | 2013-07-15 | 2016-01-06 | 河北常山生化药业股份有限公司 | A kind of membrane sepn prepares Enoxaparin Sodium technique |
| CN103936889A (en) * | 2014-03-19 | 2014-07-23 | 苏州英诺凯生物医药科技有限公司 | Method for purification of enoxaparin by tangential flow filtration |
-
2020
- 2020-04-24 SG SG11202111009WA patent/SG11202111009WA/en unknown
- 2020-04-24 MX MX2021011671A patent/MX2021011671A/en unknown
- 2020-04-24 CA CA3134458A patent/CA3134458C/en active Active
- 2020-04-24 WO PCT/ES2020/070263 patent/WO2020216981A1/en active Application Filing
- 2020-04-24 AU AU2020263142A patent/AU2020263142A1/en active Pending
- 2020-04-24 EP EP20794489.3A patent/EP3943513A4/en active Pending
- 2020-04-24 BR BR112021020048A patent/BR112021020048A2/en unknown
- 2020-04-24 KR KR1020217032026A patent/KR20220005441A/en active Search and Examination
- 2020-04-24 GE GEAP202015747A patent/GEP20247598B/en unknown
- 2020-04-24 MA MA055388A patent/MA55388A/en unknown
- 2020-04-24 JP JP2021559706A patent/JP2022530321A/en active Pending
- 2020-04-24 ES ES202090025A patent/ES2888148B2/en active Active
- 2020-04-24 PE PE2021001650A patent/PE20212330A1/en unknown
-
2021
- 2021-10-03 IL IL286931A patent/IL286931A/en unknown
- 2021-10-05 CO CONC2021/0013320A patent/CO2021013320A2/en unknown
- 2021-10-08 CL CL2021002647A patent/CL2021002647A1/en unknown
- 2021-10-25 US US17/509,255 patent/US20220112315A1/en active Pending
- 2021-11-12 ZA ZA2021/09022A patent/ZA202109022B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL286931A (en) | 2021-10-31 |
| WO2020216981A1 (en) | 2020-10-29 |
| CL2021002647A1 (en) | 2022-05-13 |
| ES2888148A1 (en) | 2021-12-30 |
| CA3134458A1 (en) | 2020-10-29 |
| EP3943513A4 (en) | 2022-12-21 |
| CO2021013320A2 (en) | 2022-03-18 |
| PE20212330A1 (en) | 2021-12-14 |
| SG11202111009WA (en) | 2021-11-29 |
| JP2022530321A (en) | 2022-06-29 |
| EP3943513A1 (en) | 2022-01-26 |
| US20220112315A1 (en) | 2022-04-14 |
| CA3134458C (en) | 2023-11-21 |
| GEP20247598B (en) | 2024-02-26 |
| AU2020263142A1 (en) | 2021-10-28 |
| KR20220005441A (en) | 2022-01-13 |
| ZA202109022B (en) | 2023-10-25 |
| MX2021011671A (en) | 2021-10-22 |
| MA55388A (en) | 2022-01-26 |
| ES2888148B2 (en) | 2022-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |