BR112021020048A2 - Method for obtaining low molecular weight heparins through tangential flow filtration - Google Patents

Method for obtaining low molecular weight heparins through tangential flow filtration

Info

Publication number
BR112021020048A2
BR112021020048A2 BR112021020048A BR112021020048A BR112021020048A2 BR 112021020048 A2 BR112021020048 A2 BR 112021020048A2 BR 112021020048 A BR112021020048 A BR 112021020048A BR 112021020048 A BR112021020048 A BR 112021020048A BR 112021020048 A2 BR112021020048 A2 BR 112021020048A2
Authority
BR
Brazil
Prior art keywords
molecular weight
low molecular
tangential flow
flow filtration
obtaining low
Prior art date
Application number
BR112021020048A
Other languages
Portuguese (pt)
Inventor
Franco Rodríguez Guilermo
Gutierro Aduriz Ibon
Original Assignee
Farm Rovi Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farm Rovi Lab Sa filed Critical Farm Rovi Lab Sa
Publication of BR112021020048A2 publication Critical patent/BR112021020048A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2649—Filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/20—Specific permeability or cut-off range

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

método para obtenção de heparinas de baixo peso molecular através de filtração de fluxo tangencial. método para obtenção de heparinas de baixo peso molecular (hbpm) com distribuição de peso molecular entre 3,0 e 5,0 kda compreendendo pelo menos uma etapa de concentração através de filtração de fluxo tangencial (tff). o método é particularmente útil para a preparação de bemiparina e enoxaparina sem a utilização de precipitação fracionada nem o uso de soluções alcoólicas. em particular, a preparação da hbpm é obtida através da despolimerização da heparina e filtração (ultrafiltração e/ou diafiltração de tff) da heparina despolimerizada sem o uso de precipitação fracionada e sem uma solução alcoólica.method for obtaining low molecular weight heparins through tangential flow filtration. method for obtaining low molecular weight heparins (hbpm) with molecular weight distribution between 3.0 and 5.0 kda comprising at least one concentration step through tangential flow filtration (tff). The method is particularly useful for the preparation of bemiparin and enoxaparin without the use of fractional precipitation or the use of alcoholic solutions. in particular, the preparation of hbpm is obtained through the depolymerization of heparin and filtration (ultrafiltration and/or tff diafiltration) of the depolymerized heparin without the use of fractional precipitation and without an alcoholic solution.

BR112021020048A 2019-04-26 2020-04-24 Method for obtaining low molecular weight heparins through tangential flow filtration BR112021020048A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES201930373 2019-04-26
CN202010078241 2020-01-23
PCT/ES2020/070263 WO2020216981A1 (en) 2019-04-26 2020-04-24 Method for obtaining low-molecular-weight heparins by means of tangential flow filtration

Publications (1)

Publication Number Publication Date
BR112021020048A2 true BR112021020048A2 (en) 2021-12-07

Family

ID=72941056

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021020048A BR112021020048A2 (en) 2019-04-26 2020-04-24 Method for obtaining low molecular weight heparins through tangential flow filtration

Country Status (18)

Country Link
US (1) US20220112315A1 (en)
EP (1) EP3943513A4 (en)
JP (1) JP2022530321A (en)
KR (1) KR20220005441A (en)
AU (1) AU2020263142A1 (en)
BR (1) BR112021020048A2 (en)
CA (1) CA3134458C (en)
CL (1) CL2021002647A1 (en)
CO (1) CO2021013320A2 (en)
ES (1) ES2888148B2 (en)
GE (1) GEP20247598B (en)
IL (1) IL286931A (en)
MA (1) MA55388A (en)
MX (1) MX2021011671A (en)
PE (1) PE20212330A1 (en)
SG (1) SG11202111009WA (en)
WO (1) WO2020216981A1 (en)
ZA (1) ZA202109022B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112023022331A2 (en) 2021-05-12 2023-12-26 Nexeos Diagnostics Inc METHODS OF MANUFACTURING A HIGH MOLECULAR WEIGHT HEPARIN COMPOUND
CN116284499A (en) * 2022-07-28 2023-06-23 河北常山生化药业股份有限公司 Preparation method of sheep-derived low-molecular heparin sodium

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245813B2 (en) 1986-05-16 2000-03-22 ITALFARMACO S.p.A. EDTA-free heparins, heparin fractions and fragments, processes for their preparation and pharmaceutical compositions containing them
US5767269A (en) 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
ES2161615B1 (en) 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT.
GB0509433D0 (en) 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
US8598337B2 (en) 2006-01-13 2013-12-03 Baxter International Inc. Method for purifying polysaccharides
ES2718275T3 (en) 2009-03-27 2019-06-28 Algenist Holdings Inc Microalgae polysaccharide compositions
CN102050888B (en) 2010-12-13 2011-12-07 河北常山生化药业股份有限公司 Method for preparing enoxaparin sodium
CN102731683A (en) * 2012-07-17 2012-10-17 湖北亿诺瑞生物制药有限公司 Method of separating natural low molecular heparin from heparin waste liquor
CN103342761B (en) 2013-07-15 2016-01-06 河北常山生化药业股份有限公司 A kind of membrane sepn prepares Enoxaparin Sodium technique
CN103936889A (en) * 2014-03-19 2014-07-23 苏州英诺凯生物医药科技有限公司 Method for purification of enoxaparin by tangential flow filtration

Also Published As

Publication number Publication date
JP2022530321A (en) 2022-06-29
US20220112315A1 (en) 2022-04-14
CA3134458C (en) 2023-11-21
ES2888148A1 (en) 2021-12-30
GEP20247598B (en) 2024-02-26
ES2888148B2 (en) 2022-11-14
MX2021011671A (en) 2021-10-22
WO2020216981A1 (en) 2020-10-29
IL286931A (en) 2021-10-31
PE20212330A1 (en) 2021-12-14
KR20220005441A (en) 2022-01-13
ZA202109022B (en) 2023-10-25
CL2021002647A1 (en) 2022-05-13
MA55388A (en) 2022-01-26
CA3134458A1 (en) 2020-10-29
EP3943513A1 (en) 2022-01-26
CO2021013320A2 (en) 2022-03-18
EP3943513A4 (en) 2022-12-21
SG11202111009WA (en) 2021-11-29
AU2020263142A1 (en) 2021-10-28

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