BR112021010660A2 - Proteína de neurofilamento para guiar intervenção terapêutica sobre esclerose lateral amiotrófica - Google Patents

Proteína de neurofilamento para guiar intervenção terapêutica sobre esclerose lateral amiotrófica Download PDF

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Publication number
BR112021010660A2
BR112021010660A2 BR112021010660-0A BR112021010660A BR112021010660A2 BR 112021010660 A2 BR112021010660 A2 BR 112021010660A2 BR 112021010660 A BR112021010660 A BR 112021010660A BR 112021010660 A2 BR112021010660 A2 BR 112021010660A2
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Brazil
Prior art keywords
therapeutic
patient
level
biological sample
neurofilament
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BR112021010660-0A
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English (en)
Portuguese (pt)
Inventor
Toby Arlo Ferguson
Danielle Leezetta Graham
Steve Sang-Woo Han
Alexander Reid Vincent Mccampbell
Giulio Srubek-Tomassy
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Biogen Ma Inc.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/35—Nature of the modification
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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  • Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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BR112021010660-0A 2018-12-06 2019-12-03 Proteína de neurofilamento para guiar intervenção terapêutica sobre esclerose lateral amiotrófica BR112021010660A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862776253P 2018-12-06 2018-12-06
US62/776,253 2018-12-06
US201962840431P 2019-04-30 2019-04-30
US62/840,431 2019-04-30
US201962842063P 2019-05-02 2019-05-02
US62/842,063 2019-05-02
PCT/US2019/064190 WO2020117772A1 (en) 2018-12-06 2019-12-03 Neurofilament protein for guiding therapeutic intervention in amyotrophic lateral sclerosis

Publications (1)

Publication Number Publication Date
BR112021010660A2 true BR112021010660A2 (pt) 2021-08-24

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BR112021010660-0A BR112021010660A2 (pt) 2018-12-06 2019-12-03 Proteína de neurofilamento para guiar intervenção terapêutica sobre esclerose lateral amiotrófica

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Country Link
US (1) US12429487B2 (https=)
EP (1) EP3890752A1 (https=)
JP (2) JP2022513721A (https=)
KR (1) KR20210102294A (https=)
CN (1) CN113365640A (https=)
BR (1) BR112021010660A2 (https=)
CA (1) CA3121749A1 (https=)
MA (1) MA54383A (https=)
MX (1) MX2021006548A (https=)
WO (1) WO2020117772A1 (https=)

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MA54383A (fr) 2018-12-06 2021-10-13 Biogen Ma Inc Protéine neurofilamenteuse pour guider une intervention thérapeutique dans la sclérose laterale amyotrophique
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US20230365937A1 (en) * 2020-10-26 2023-11-16 Hadasit Medical Research Services And Development Ltd. Mesenchymal stem cells and their culture
KR200498472Y1 (ko) 2024-05-23 2024-10-24 김민경 경고 또는 안내 문구를 교체형으로 구성시킬 수 있는 배수용 그레이팅

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CA3121749A1 (en) 2020-06-11
JP2024096258A (ja) 2024-07-12
MA54383A (fr) 2021-10-13
CN113365640A (zh) 2021-09-07
JP2022513721A (ja) 2022-02-09
WO2020117772A1 (en) 2020-06-11
EP3890752A1 (en) 2021-10-13
US12429487B2 (en) 2025-09-30
MX2021006548A (es) 2021-09-21
US20220034907A1 (en) 2022-02-03
KR20210102294A (ko) 2021-08-19

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