BR112019014985A8 - STABLE COMPOSITION OF FAT-SOLUBLE ACTIVE INGREDIENT, MICROCAPSULE AND PROCESS OF PREPARATION AND USE OF THE SAME - Google Patents

STABLE COMPOSITION OF FAT-SOLUBLE ACTIVE INGREDIENT, MICROCAPSULE AND PROCESS OF PREPARATION AND USE OF THE SAME

Info

Publication number
BR112019014985A8
BR112019014985A8 BR112019014985A BR112019014985A BR112019014985A8 BR 112019014985 A8 BR112019014985 A8 BR 112019014985A8 BR 112019014985 A BR112019014985 A BR 112019014985A BR 112019014985 A BR112019014985 A BR 112019014985A BR 112019014985 A8 BR112019014985 A8 BR 112019014985A8
Authority
BR
Brazil
Prior art keywords
active ingredient
fat
soluble active
stable composition
microcapsule
Prior art date
Application number
BR112019014985A
Other languages
Portuguese (pt)
Other versions
BR112019014985A2 (en
BR112019014985B1 (en
Inventor
Mao Guoquan
Zhu Hongming
Ma Wenxin
Liang Zhiping
Qian Li
Bernhard Lüebbe Fritz
Hu Siping
Li Chun
Wen Shanping
Wang Qinlan
Kong Huajuan
Original Assignee
Zhejiang Med Xinchang Pharm
Zhejiang Medicine Co Ltd Vitamin Factory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Med Xinchang Pharm, Zhejiang Medicine Co Ltd Vitamin Factory filed Critical Zhejiang Med Xinchang Pharm
Priority claimed from PCT/CN2018/073371 external-priority patent/WO2018133833A1/en
Publication of BR112019014985A2 publication Critical patent/BR112019014985A2/en
Publication of BR112019014985A8 publication Critical patent/BR112019014985A8/en
Publication of BR112019014985B1 publication Critical patent/BR112019014985B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins
    • A23V2250/708—Vitamin C
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins
    • A23V2250/712—Vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fodder In General (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

A presente invenção provê uma composição estável de ingrediente ativo lipossolúvel, uma microcápsula e um processo para a preparação e uso da mesma. A composição estável de ingrediente ativo lipossolúvel compreende tocoferol, palmitato de Vitamina C e um ingrediente ativo lipossolúvel, onde a razão em peso de tocoferol para palmitato de Vitamina C é 2-8:1, a razão em peso de uma combinação de tocoferol com palmitato de Vitamina C para o ingrediente ativo lipossolúvel é 7-13:100. A presente invenção obtém uma nova composição antioxidante sem perigos ocultos para melhorar a estabilidade do ingrediente ativo pelo rastreio de uma combinação de antioxidantes e ajuste de sua proporção e dosagem.The present invention provides a stable composition of liposoluble active ingredient, a microcapsule and a process for preparing and using the same. The stable composition of fat-soluble active ingredient comprises tocopherol, Vitamin C palmitate and a fat-soluble active ingredient, where the weight ratio of tocopherol to Vitamin C palmitate is 2-8:1, the weight ratio of a combination of tocopherol and palmitate of Vitamin C for the fat-soluble active ingredient is 7-13:100. The present invention obtains a new antioxidant composition without hidden dangers to improve the stability of the active ingredient by screening a combination of antioxidants and adjusting their ratio and dosage.

BR112019014985-6A 2017-01-20 2018-01-19 STABLE COMPOSITION OF FAT-SOLUBLE ACTIVE INGREDIENT, MICROCAPSULE AND PROCESS OF PREPARATION AND USE OF THE SAME BR112019014985B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201710042526.X 2017-01-20
CN201710042526 2017-01-20
CN201710694878.3 2017-08-15
CN201710694878.3A CN108324699A (en) 2017-01-20 2017-08-15 Stable fat-soluble active ingredient composition, micro-capsule and its preparation method and application
PCT/CN2018/073371 WO2018133833A1 (en) 2017-01-20 2018-01-19 Stable and liposoluble active ingredient composition, microcapsule, and preparation method and application thereof

Publications (3)

Publication Number Publication Date
BR112019014985A2 BR112019014985A2 (en) 2020-04-07
BR112019014985A8 true BR112019014985A8 (en) 2023-03-14
BR112019014985B1 BR112019014985B1 (en) 2023-03-28

Family

ID=62921848

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019014985-6A BR112019014985B1 (en) 2017-01-20 2018-01-19 STABLE COMPOSITION OF FAT-SOLUBLE ACTIVE INGREDIENT, MICROCAPSULE AND PROCESS OF PREPARATION AND USE OF THE SAME

Country Status (8)

Country Link
JP (1) JP2020508695A (en)
KR (1) KR102571958B1 (en)
CN (1) CN108324699A (en)
AU (1) AU2018208993B2 (en)
BR (1) BR112019014985B1 (en)
CA (1) CA3051023A1 (en)
MX (1) MX2019008650A (en)
SG (1) SG11201906708WA (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109674062A (en) * 2019-02-01 2019-04-26 浙江花园营养科技有限公司 A kind of preparation method of stability vitamine D3 nano freeze-dried powder
BR112022016273A2 (en) * 2020-02-18 2022-10-04 Basf Se BUTYL HYDROXY TOLUENE POWDER FORMULATION AND, USE OF A FORMULATION
CN111544415B (en) * 2020-05-29 2022-08-05 大连医诺生物股份有限公司 High acid-resistant vitamin A product and preparation method thereof
CN112401067A (en) * 2020-09-27 2021-02-26 天津农学院 Feed additive for increasing deposition amount of coenzyme Q10 in egg yolk and application thereof
CN112603850B (en) * 2021-02-04 2023-09-19 雅弗生物实验室有限公司(加拿大) Vitamin C permanent magnet whitening anti-aging membrane cloth and preparation method thereof
CN115137018B (en) * 2021-03-30 2024-03-15 新发药业有限公司 Vitamin A and derivative composition thereof
CN114452259A (en) * 2021-07-28 2022-05-10 安徽旺盛添加剂有限公司 Vitamin D micro-capsule calcium tablet and preparation method thereof
KR20230047243A (en) 2021-09-30 2023-04-07 고려자연식품(주) Method for preparing of microcapsules including fat solubility, microcapsules prepared by the method and jelly including the same
CN114209065A (en) * 2021-12-20 2022-03-22 四川内江汇鑫制药有限公司 Vitamin D2Microcapsule powder and preparation method thereof
CN114588067A (en) * 2022-03-18 2022-06-07 上海世领制药有限公司 Hydroxy pinacolone retinoic acid ester high-oil permeation-promoting carrier, preparation method and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1066761B1 (en) * 1999-07-06 2004-09-29 DSM IP Assets B.V. Compositions containing fat-soluble substances in a carbohydrate matrix
ES2189697B1 (en) * 2001-12-28 2005-02-01 Antibioticos, S.A.U. PROCEDURE FOR OBTAINING NEW FORMULATIONS BASED ON LUTEINE.
DE102005031464A1 (en) * 2005-07-04 2007-01-18 Basf Ag Emulsifier system, emulsion and their use
JP5982086B2 (en) * 2005-10-21 2016-08-31 ディーエスエム アイピー アセッツ ビー．ブイ． Novel formulation of fat-soluble active ingredients with high bioavailability
CN1850062B (en) * 2006-02-24 2010-11-03 无锡杰西医药科技有限公司 Fatty acid eye nano preparations for dry eye disease
JP2012139175A (en) * 2010-12-29 2012-07-26 Riken Vitamin Co Ltd Fat-and-oil composition for frying
CN102362864B (en) * 2011-10-26 2013-03-13 浙江新维普添加剂有限公司 Method for raising free-flowing property and bulk density of vitamin A or vitamin D3 microcapsules
CN102550817B (en) * 2011-12-31 2013-11-20 厦门金达威集团股份有限公司 Functional oil microencapsulation and manufacturing method thereof
CN102525923B (en) * 2012-02-16 2014-09-10 中国农业大学 Preparation method of carotenoid emulsion and microcapsules
EP2862447A1 (en) * 2013-10-16 2015-04-22 Idcaps Multilayer microcapsules containing an oxidizable active, and a process for preparing the same

Also Published As

Publication number Publication date
CA3051023A1 (en) 2018-07-26
KR102571958B1 (en) 2023-08-29
KR20200015884A (en) 2020-02-13
AU2018208993B2 (en) 2021-07-08
MX2019008650A (en) 2020-01-30
SG11201906708WA (en) 2019-08-27
JP2020508695A (en) 2020-03-26
CN108324699A (en) 2018-07-27
BR112019014985A2 (en) 2020-04-07
AU2018208993A1 (en) 2019-09-05
BR112019014985B1 (en) 2023-03-28

Similar Documents

Publication Publication Date Title
BR112019014985A8 (en) STABLE COMPOSITION OF FAT-SOLUBLE ACTIVE INGREDIENT, MICROCAPSULE AND PROCESS OF PREPARATION AND USE OF THE SAME
ZA202102544B (en) Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof
UY38001A (en) COMPOUNDS THAT INHIBIT THE MUTANT RAS PROTEINS G12C
Silva et al. DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A2A receptor
CY1120628T1 (en) FLAVONID BASED COMPOSITION FOR PHARMACEUTICAL, NUTRITIONAL OR COSMETIC USE THAT HAVE ENHANCED ANTIOXIDANT ACTION
BR112016025876A8 (en) composition, processes for preparing a microcapsule and a unit dosage form, unit dosage form, microcapsule, product, use of a composition, and, method of treating a condition associated with vitamin k1 or k2
BR112022016273A2 (en) BUTYL HYDROXY TOLUENE POWDER FORMULATION AND, USE OF A FORMULATION
CL2019001658A1 (en) Tricyclic enone pyrimidine derivatives for rory inhibition and other uses.
BR112015010703A8 (en) USE OF A PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL COMPOSITION
ECSP15000868A (en) ESTRA–1,3,5(10),16–TETRAENE 3–SUBSTITUTED DERIVATIVES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM, AS WELL AS THEIR USE FOR THE PREPARATION OF MEDICINES
CO2022004723A2 (en) Heteroaryl biphenyl amides for the treatment of diseases related to the pd-l1 ligand
CO2022018636A2 (en) il-17a modulators
BR112018006730A2 (en) method for preparing a compound, substance or mixture of substance, use of at least one substance or mixture of substance, fragrance composition, and, agent.
CY1122731T1 (en) ESTROGEN RECEPTOR MODULATORS
BR112015029590A2 (en) dietary supplement and its use
CO2022016899A2 (en) il-17a modulators
Moccia et al. A carotenoid-enriched extract from pumpkin delays cell proliferation in a human chronic lymphocytic leukemia cell line through the modulation of autophagic flux
ITMI20072051A1 (en) PELLET BASED COMPOSITION OF LIPOIC ACID
NZ746666A (en) New tablettable formulation of lutein and/or zeaxanthin
ECSP21037191A (en) PIRAZOLES AS HEMOGLOBIN MODULATORS
BR112022006701A2 (en) XANTHOPHYLL COMPOSITION COMPRISING LUTEIN AND ZEAXANTHINE WITH IMPROVED BIOAVAILABILITY
CL2023002274A1 (en) Tricyclic compounds and their uses
MY192213A (en) A composition for preventing or mitigating dementia
MX2015008733A (en) 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders.
BR112013026933A2 (en) use of a combination of at least one carotenoid

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/01/2018, OBSERVADAS AS CONDICOES LEGAIS