BR112018003823A2 - compostos auxiliares inibidores de metaloproteinase de matriz para dispositivos cirúrgicos - Google Patents
compostos auxiliares inibidores de metaloproteinase de matriz para dispositivos cirúrgicosInfo
- Publication number
- BR112018003823A2 BR112018003823A2 BR112018003823A BR112018003823A BR112018003823A2 BR 112018003823 A2 BR112018003823 A2 BR 112018003823A2 BR 112018003823 A BR112018003823 A BR 112018003823A BR 112018003823 A BR112018003823 A BR 112018003823A BR 112018003823 A2 BR112018003823 A2 BR 112018003823A2
- Authority
- BR
- Brazil
- Prior art keywords
- wound healing
- matrix metalloproteinase
- metalloproteinase inhibitor
- surgical devices
- stage
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title abstract 2
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 3
- 230000029663 wound healing Effects 0.000 abstract 3
- 230000000717 retained effect Effects 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000007634 remodeling Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07292—Reinforcements for staple line, e.g. pledgets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/115—Staplers for performing anastomosis in a single operation
- A61B17/1155—Circular staplers comprising a plurality of staples
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07207—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously the staples being applied sequentially
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/0046—Surgical instruments, devices or methods, e.g. tourniquets with a releasable handle; with handle and operating part separable
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00818—Treatment of the gastro-intestinal system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B2017/00831—Material properties
- A61B2017/00889—Material properties antimicrobial, disinfectant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00893—Material properties pharmaceutically effective
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
- A61B2017/07271—Stapler heads characterised by its cartridge
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
- A61B2017/2926—Details of heads or jaws
- A61B2017/2927—Details of heads or jaws the angular position of the head being adjustable with respect to the shaft
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/434—Inhibitors, antagonists of enzymes
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Surgical Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers & Plastics (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
vários compostos auxiliares exemplificadores inibidores da metaloproteinase de matriz (mmp) para dispositivos cirúrgicos são fornecidos. em geral, um composto adjuvante implantável pode ser configurado para ser aplicado a um tecido por meio de um grampeador cirúrgico, em conjunto com grampos. o composto auxiliar pode ter ao menos um medicamento retido de modo liberável no interior do mesmo, que é configurado de modo a reduzir a duração do processo de epitelização. em outras palavras, o medicamento retido de maneira liberável no material auxiliar pode ser configurado para acelerar um estágio de inflamação da cura de ferimentos e/ou o estágio de proliferação da cura de ferimentos; e, por conseguinte, reduzir o intervalo de tempo antes do início de um estágio de remodelamento da cura de ferimentos. o medicamento pode ser configurado para ser liberado ao longo da linha de grampos definida pelos grampos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/840,406 US10111661B2 (en) | 2015-08-31 | 2015-08-31 | Matrix metalloproteinase inhibiting adjuncts for surgical devices |
PCT/US2016/048366 WO2017040141A1 (en) | 2015-08-31 | 2016-08-24 | Matrix metalloproteinase inhibiting adjuncts for surgical devices |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018003823A2 true BR112018003823A2 (pt) | 2018-09-25 |
Family
ID=56851485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018003823A BR112018003823A2 (pt) | 2015-08-31 | 2016-08-24 | compostos auxiliares inibidores de metaloproteinase de matriz para dispositivos cirúrgicos |
Country Status (6)
Country | Link |
---|---|
US (1) | US10111661B2 (pt) |
EP (2) | EP3662939B1 (pt) |
JP (1) | JP6946273B2 (pt) |
CN (1) | CN108348638B (pt) |
BR (1) | BR112018003823A2 (pt) |
WO (1) | WO2017040141A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US20220175370A1 (en) * | 2010-09-30 | 2022-06-09 | Cilag Gmbh International | Tissue thickness compensator comprising at least one medicament |
US10130738B2 (en) * | 2015-08-31 | 2018-11-20 | Ethicon Llc | Adjunct material to promote tissue growth |
US10245034B2 (en) | 2015-08-31 | 2019-04-02 | Ethicon Llc | Inducing tissue adhesions using surgical adjuncts and medicants |
US10569071B2 (en) | 2015-08-31 | 2020-02-25 | Ethicon Llc | Medicant eluting adjuncts and methods of using medicant eluting adjuncts |
US10076329B2 (en) * | 2015-08-31 | 2018-09-18 | Ethicon Llc | Adjunct material to promote tissue growth in a colon |
US10285692B2 (en) * | 2015-08-31 | 2019-05-14 | Ethicon Llc | Adjuncts for surgical devices including agonists and antagonists |
US11058804B2 (en) | 2017-06-13 | 2021-07-13 | Ethicon Llc | Surgical fastener device for the prevention of ECM degradation |
US10939911B2 (en) | 2017-06-13 | 2021-03-09 | Ethicon Llc | Surgical stapler with end effector coating |
US10799237B2 (en) | 2018-02-21 | 2020-10-13 | Ethicon Llc | Three dimensional adjuncts |
USD882782S1 (en) | 2018-02-21 | 2020-04-28 | Ethicon Llc | Three dimensional adjunct |
US11490890B2 (en) | 2019-09-16 | 2022-11-08 | Cilag Gmbh International | Compressible non-fibrous adjuncts |
US11540833B2 (en) | 2019-09-16 | 2023-01-03 | Cilag Gmbh International | Compressible non-fibrous adjuncts |
USD1029255S1 (en) | 2020-09-01 | 2024-05-28 | Cilag Gmbh International | Stapling cartridge assembly with a compressible adjunct |
US11849950B2 (en) | 2021-03-30 | 2023-12-26 | Cilag Gmbh International | Compressible adjuncts with drug dosage control features |
US11896226B2 (en) | 2021-03-30 | 2024-02-13 | Cilag Gmbh International | Compressible adjuncts with healing-dependent degradation profile |
US11850332B2 (en) | 2021-03-30 | 2023-12-26 | Cilag Gmbh International | Method for treating tissue |
US11864765B2 (en) * | 2021-03-30 | 2024-01-09 | Cilag Gmbh International | Compressible adjuncts with fluid control features |
US11786240B2 (en) | 2021-03-30 | 2023-10-17 | Cilag Gmbh International | Using smart packaging in adjusting use of tissue adjuncts |
US11839374B2 (en) * | 2021-03-30 | 2023-12-12 | Cilag Gmbh International | Compressible adjuncts with drug release features |
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-
2015
- 2015-08-31 US US14/840,406 patent/US10111661B2/en active Active
-
2016
- 2016-08-24 WO PCT/US2016/048366 patent/WO2017040141A1/en active Application Filing
- 2016-08-24 JP JP2018511019A patent/JP6946273B2/ja active Active
- 2016-08-24 CN CN201680063586.3A patent/CN108348638B/zh active Active
- 2016-08-24 BR BR112018003823A patent/BR112018003823A2/pt not_active Application Discontinuation
- 2016-08-30 EP EP19198978.9A patent/EP3662939B1/en active Active
- 2016-08-30 EP EP16186419.4A patent/EP3135308A1/en not_active Ceased
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US10111661B2 (en) | 2018-10-30 |
JP2018531646A (ja) | 2018-11-01 |
US20170055984A1 (en) | 2017-03-02 |
EP3662939C0 (en) | 2024-01-03 |
EP3662939B1 (en) | 2024-01-03 |
EP3135308A1 (en) | 2017-03-01 |
JP6946273B2 (ja) | 2021-10-06 |
WO2017040141A1 (en) | 2017-03-09 |
CN108348638A (zh) | 2018-07-31 |
EP3662939A1 (en) | 2020-06-10 |
CN108348638B (zh) | 2021-10-26 |
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